| Rank | City | 2020 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 137,566 | 1.5% |
| 2 | Columbia | 131,674 | 0.2% |
| 3 | North Charleston | 115,382 | 1.9% |
| 4 | Mount Pleasant | 91,684 | 3.4% |
| 5 | Rock Hill | 75,048 | 1.4% |
| 6 | Greenville | 70,635 | 2.1% |
| 7 | Summerville | 52,549 | 2.2% |
| 8 | Goose Creek | 43,665 | 2.2% |
| 9 | Hilton Head Island | 39,861 | 0.8% |
| 10 | Sumter | 39,642 | -0.2% |
| 11 | Florence | 38,531 | 0.4% |
| 12 | Spartanburg | 37,399 | 0.1% |
| 13 | Myrtle Beach | 34,695 | 2.8% |
| 14 | Greer | 33,373 | 3.0% |
| 15 | Aiken | 30,869 | 0.5% |
| 16 | Anderson | 27,676 | 0.4% |
| 17 | Hanahan | 26,917 | 4.6% |
| 18 | Conway | 25,956 | 4.7% |
| 19 | Bluffton | 25,557 | 8.2% |
| 20 | Mauldin | 25,409 | 1.2% |
| 21 | Simpsonville | 24,221 | 3.2% |
| 22 | North Augusta | 23,845 | 1.2% |
| 23 | Greenwood | 23,403 | 0.1% |
| 24 | Fort Mill | 22,284 | 8.4% |
| 25 | Lexington | 22,157 | 2.4% |
| 26 | Easley | 21,364 | 0.7% |
| 27 | West Columbia | 17,998 | 2.1% |
| 28 | Clemson | 17,501 | 2.6% |
| 29 | North Myrtle Beach | 16,819 | 2.3% |
| 30 | Cayce | 14,009 | 1.2% |
| 31 | Beaufort | 13,436 | 0.9% |
| 32 | Port Royal | 13,235 | 2.4% |
| 33 | Orangeburg | 12,654 | -1.1% |
| 34 | Gaffney | 12,609 | 0.2% |
| 35 | Irmo | 12,483 | 1.3% |
| 36 | James Island | 12,109 | – |
| 37 | Moncks Corner | 11,986 | 4.8% |
| 38 | Tega Cay | 11,335 | 4.5% |
| 39 | Fountain Inn | 10,441 | 3.3% |
| 40 | Forest Acres | 10,298 | -0.1% |
| 41 | Newberry | 10,199 | -0.1% |
| 42 | Lancaster | 9,119 | 0.7% |
| 43 | Laurens | 8,849 | -0.4% |
| 44 | Georgetown | 8,742 | -0.5% |
| 45 | Seneca | 8,533 | 0.6% |
| 46 | York | 8,412 | 0.9% |
| 47 | Clinton | 8,380 | -0.1% |
| 48 | Bennettsville | 7,730 | -1.8% |
| 49 | Union | 7,640 | -1.0% |
| 50 | Hartsville | 7,542 | -0.3% |
| 51 | Hardeeville | 7,278 | 10.5% |
| 52 | Camden | 7,220 | 0.6% |
| 53 | Clover | 6,519 | 2.8% |
| 54 | Lake City | 6,497 | -0.3% |
| 55 | Marion | 6,326 | -1.0% |
| 56 | Dillon | 6,311 | -0.8% |
| 57 | Darlington | 5,940 | -0.6% |
| 58 | Cheraw | 5,562 | -0.6% |
| 59 | Walterboro | 5,426 | 0.1% |
| 60 | Batesburg-Leesville | 5,415 | 0.1% |
| 61 | Central | 5,385 | 0.5% |
| 62 | Chester | 5,377 | -0.5% |
| 63 | Travelers Rest | 5,346 | 1.7% |
| 64 | Hollywood | 5,227 | 1.2% |
| 65 | Abbeville | 5,014 | -0.5% |
| 66 | Edgefield | 4,810 | 0.1% |
| 67 | Surfside Beach | 4,525 | 1.8% |
| 68 | Walhalla | 4,472 | 0.5% |
| 69 | Belton | 4,455 | 0.8% |
| 70 | Woodruff | 4,418 | 0.9% |
| 71 | Isle of Palms | 4,360 | 0.6% |
| 72 | Barnwell | 4,291 | -1.1% |
| 73 | Williamston | 4,260 | 0.9% |
| 74 | Mullins | 4,239 | -1.1% |
| 75 | Blythewood | 4,150 | 8.2% |
| 76 | Manning | 3,892 | -0.6% |
| 77 | Honea Path | 3,826 | 0.7% |
| 78 | Ridgeland | 3,811 | -0.6% |
| 79 | Lyman | 3,718 | 1.5% |
| 80 | Duncan | 3,626 | 1.5% |
| 81 | Saluda | 3,605 | 0.1% |
| 82 | Pendleton | 3,285 | 1.1% |
| 83 | Bamberg | 3,189 | -1.4% |
| 84 | Winnsboro | 3,181 | -1.2% |
| 85 | Pickens | 3,170 | 0.2% |
| 86 | Liberty | 3,154 | -0.4% |
| 87 | Kingstree | 3,063 | -0.9% |
| 88 | Bishopville | 3,017 | -1.5% |
| 89 | Denmark | 2,934 | -2.1% |
| 90 | Williston | 2,925 | -0.8% |
| 91 | Allendale | 2,924 | -1.9% |
| 92 | Andrews | 2,859 | -0.0% |
| 93 | Loris | 2,761 | 1.6% |
| 94 | Burnettown | 2,747 | 0.3% |
| 95 | Springdale | 2,733 | 0.4% |
| 96 | Ravenel | 2,720 | 1.1% |
| 97 | Wellford | 2,718 | 1.5% |
| 98 | Landrum | 2,677 | 1.3% |
| 99 | Folly Beach | 2,660 | 0.2% |
| 100 | Pageland | 2,636 | -0.5% |
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