| Rank | City | 1990 Population |
|---|---|---|
| 1 | Columbia | 114,462 |
| 2 | Charleston | 90,620 |
| 3 | North Charleston | 85,384 |
| 4 | Greenville | 58,548 |
| 5 | Spartanburg | 43,673 |
| 6 | Sumter | 43,181 |
| 7 | Rock Hill | 42,894 |
| 8 | Mount Pleasant | 31,072 |
| 9 | Florence | 30,881 |
| 10 | Anderson | 26,649 |
| 11 | Goose Creek | 25,869 |
| 12 | Myrtle Beach | 25,200 |
| 13 | Hilton Head Island | 23,733 |
| 14 | Summerville | 22,030 |
| 15 | Greenwood | 20,790 |
| 16 | Aiken | 20,733 |
| 17 | North Augusta | 15,669 |
| 18 | Easley | 15,330 |
| 19 | Orangeburg | 13,978 |
| 20 | Gaffney | 13,616 |
| 21 | Hanahan | 13,177 |
| 22 | West Columbia | 12,651 |
| 23 | Greer | 11,947 |
| 24 | Simpsonville | 11,809 |
| 25 | Mauldin | 11,708 |
| 26 | Cayce | 11,599 |
| 27 | Irmo | 11,415 |
| 28 | Clemson | 11,024 |
| 29 | Newberry | 10,880 |
| 30 | Bennettsville | 10,407 |
| 31 | Conway | 10,097 |
| 32 | Laurens | 10,080 |
| 33 | Forest Acres | 10,041 |
| 34 | Beaufort | 9,901 |
| 35 | Clinton | 9,872 |
| 36 | Union | 9,849 |
| 37 | Georgetown | 9,703 |
| 38 | Lancaster | 9,523 |
| 39 | North Myrtle Beach | 9,063 |
| 40 | Hartsville | 8,713 |
| 41 | Marion | 7,980 |
| 42 | Darlington | 7,933 |
| 43 | Seneca | 7,626 |
| 44 | Camden | 7,370 |
| 45 | Chester | 7,322 |
| 46 | Lake City | 7,157 |
| 47 | Dillon | 7,059 |
| 48 | York | 6,689 |
| 49 | Abbeville | 6,323 |
| 50 | Cheraw | 6,088 |
| 51 | Mullins | 5,960 |
| 52 | Batesburg-Leesville | 5,920 |
| 53 | Moncks Corner | 5,787 |
| 54 | Walterboro | 5,650 |
| 55 | Barnwell | 5,545 |
| 56 | Fort Mill | 5,251 |
| 57 | Manning | 4,832 |
| 58 | Fountain Inn | 4,616 |
| 59 | Belton | 4,450 |
| 60 | Allendale | 4,422 |
| 61 | Woodruff | 4,415 |
| 62 | Surfside Beach | 4,339 |
| 63 | Lexington | 4,178 |
| 64 | Williamston | 4,106 |
| 65 | Kingstree | 4,003 |
| 66 | Walhalla | 3,938 |
| 67 | Honea Path | 3,852 |
| 68 | Denmark | 3,850 |
| 69 | Winnsboro | 3,849 |
| 70 | Bamberg | 3,815 |
| 71 | Bishopville | 3,787 |
| 72 | Isle of Palms | 3,680 |
| 73 | Hollywood | 3,613 |
| 74 | Clover | 3,596 |
| 75 | Springdale | 3,479 |
| 76 | Liberty | 3,438 |
| 77 | Pickens | 3,365 |
| 78 | Pendleton | 3,364 |
| 79 | Westminster | 3,239 |
| 80 | Travelers Rest | 3,223 |
| 81 | Hampton | 3,143 |
| 82 | Williston | 3,133 |
| 83 | Andrews | 3,103 |
| 84 | Port Royal | 3,032 |
| 85 | Tega Cay | 3,013 |
| 86 | Saluda | 2,959 |
| 87 | Edgefield | 2,845 |
| 88 | McColl | 2,810 |
| 89 | Pageland | 2,795 |
| 90 | Landrum | 2,704 |
| 91 | Johnston | 2,688 |
| 92 | Central | 2,631 |
| 93 | New Ellenton | 2,616 |
| 94 | Pacolet | 2,602 |
| 95 | Blackville | 2,563 |
| 96 | Ware Shoals | 2,525 |
| 97 | Lyman | 2,466 |
| 98 | Burnettown | 2,445 |
| 99 | Estill | 2,441 |
| 100 | Timmonsville | 2,403 |
In 1990, the largest city in South Carolina was Columbia, with a population of 114,462. The second largest city is Charleston, with a population of 90,620.
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