| Rank | City | 2023 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 153,745 | 0.9% |
| 2 | Columbia | 139,676 | 0.9% |
| 3 | North Charleston | 118,598 | 1.2% |
| 4 | Mount Pleasant | 94,643 | 2.1% |
| 5 | Rock Hill | 75,361 | 0.8% |
| 6 | Greenville | 72,381 | 1.0% |
| 7 | Summerville | 51,646 | 0.6% |
| 8 | Goose Creek | 47,602 | 2.0% |
| 9 | Sumter | 42,734 | -0.7% |
| 10 | Greer | 42,075 | 8.4% |
| 11 | Florence | 40,231 | 0.4% |
| 12 | Spartanburg | 38,602 | 0.1% |
| 13 | Myrtle Beach | 38,426 | 3.2% |
| 14 | Hilton Head Island | 38,056 | -0.0% |
| 15 | Bluffton | 34,434 | 9.5% |
| 16 | Aiken | 32,512 | 1.1% |
| 17 | Fort Mill | 30,900 | 10.6% |
| 18 | Anderson | 29,785 | 1.0% |
| 19 | Conway | 27,414 | 10.2% |
| 20 | Mauldin | 26,909 | 4.2% |
| 21 | Simpsonville | 26,725 | 6.5% |
| 22 | North Augusta | 25,272 | 1.8% |
| 23 | Lexington | 24,646 | 2.3% |
| 24 | Easley | 24,461 | 3.0% |
| 25 | Greenwood | 22,445 | 0.3% |
| 26 | Hanahan | 21,455 | 1.9% |
| 27 | North Myrtle Beach | 19,851 | 2.0% |
| 28 | Clemson | 17,851 | 0.1% |
| 29 | West Columbia | 17,711 | 1.0% |
| 30 | Port Royal | 15,584 | 9.9% |
| 31 | Moncks Corner | 15,247 | 6.7% |
| 32 | Tega Cay | 13,686 | 2.8% |
| 33 | Cayce | 13,667 | -0.4% |
| 34 | Beaufort | 13,656 | 2.8% |
| 35 | Orangeburg | 13,345 | 2.7% |
| 36 | Gaffney | 12,463 | -0.4% |
| 37 | Irmo | 11,941 | 1.5% |
| 38 | James Island | 11,762 | 0.7% |
| 39 | Fountain Inn | 11,751 | 5.8% |
| 40 | Newberry | 10,747 | 1.3% |
| 41 | Forest Acres | 10,445 | -0.8% |
| 42 | Hardeeville | 10,248 | 15.1% |
| 43 | Laurens | 9,295 | -0.2% |
| 44 | Seneca | 8,979 | 0.8% |
| 45 | Lancaster | 8,863 | 2.3% |
| 46 | York | 8,652 | 0.7% |
| 47 | Georgetown | 8,546 | 1.2% |
| 48 | Travelers Rest | 8,483 | 4.9% |
| 49 | Camden | 8,223 | 2.9% |
| 50 | Union | 7,941 | -1.2% |
| 51 | Clinton | 7,555 | -1.1% |
| 52 | Hartsville | 7,425 | -0.9% |
| 53 | Clover | 7,398 | 4.7% |
| 54 | Bennettsville | 6,644 | -2.7% |
| 55 | Lyman | 6,504 | 2.4% |
| 56 | Dillon | 6,335 | -0.1% |
| 57 | Marion | 6,214 | -1.4% |
| 58 | Darlington | 6,086 | -0.4% |
| 59 | Lake City | 5,994 | 0.7% |
| 60 | Blythewood | 5,831 | 9.7% |
| 61 | Walterboro | 5,457 | -0.3% |
| 62 | Hollywood | 5,373 | -0.1% |
| 63 | Central | 5,339 | 0.8% |
| 64 | Batesburg-Leesville | 5,270 | 0.2% |
| 65 | Chester | 5,198 | -0.7% |
| 66 | Cheraw | 4,994 | -0.1% |
| 67 | Abbeville | 4,853 | 0.0% |
| 68 | Barnwell | 4,597 | 1.0% |
| 69 | Belton | 4,443 | 1.1% |
| 70 | Woodruff | 4,434 | 2.5% |
| 71 | Isle of Palms | 4,356 | 0.3% |
| 72 | Duncan | 4,287 | 2.7% |
| 73 | Surfside Beach | 4,279 | 0.9% |
| 74 | Williamston | 4,153 | 1.2% |
| 75 | Walhalla | 4,147 | 1.0% |
| 76 | Edgefield | 3,994 | 30.8% |
| 77 | Mullins | 3,892 | -1.2% |
| 78 | Manning | 3,804 | -1.1% |
| 79 | Honea Path | 3,787 | 1.3% |
| 80 | Ridgeland | 3,780 | 1.3% |
| 81 | Pendleton | 3,596 | 1.4% |
| 82 | Wellford | 3,519 | 2.4% |
| 83 | Pickens | 3,393 | 0.2% |
| 84 | Liberty | 3,299 | -1.2% |
| 85 | Winnsboro | 3,276 | 1.2% |
| 86 | Inman | 3,153 | 2.6% |
| 87 | Burnettown | 3,147 | 0.4% |
| 88 | Kingstree | 3,112 | -2.0% |
| 89 | Denmark | 3,094 | -1.0% |
| 90 | Saluda | 3,064 | -0.8% |
| 91 | Bamberg | 2,983 | -1.3% |
| 92 | Bishopville | 2,914 | -1.3% |
| 93 | Williston | 2,865 | -0.2% |
| 94 | Springdale | 2,722 | -0.4% |
| 95 | Loris | 2,637 | 3.3% |
| 96 | Hampton | 2,620 | -4.2% |
| 97 | Landrum | 2,615 | 2.4% |
| 98 | Ravenel | 2,603 | 1.2% |
| 99 | Andrews | 2,539 | -0.7% |
| 100 | Allendale | 2,509 | -4.3% |
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