| Rank | City | 2010 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 129,272 | 0.8% |
| 2 | Charleston | 120,083 | 1.9% |
| 3 | North Charleston | 97,471 | 1.8% |
| 4 | Mount Pleasant | 67,843 | 3.3% |
| 5 | Rock Hill | 66,154 | 2.7% |
| 6 | Greenville | 58,409 | 0.3% |
| 7 | Summerville | 43,392 | 4.4% |
| 8 | Sumter | 40,524 | -0.0% |
| 9 | Hilton Head Island | 37,099 | 0.9% |
| 10 | Florence | 37,056 | 1.6% |
| 11 | Spartanburg | 37,013 | -0.8% |
| 12 | Goose Creek | 35,938 | 1.3% |
| 13 | Aiken | 29,524 | 1.2% |
| 14 | Myrtle Beach | 27,109 | 1.1% |
| 15 | Anderson | 26,686 | 0.3% |
| 16 | Greer | 25,515 | 3.6% |
| 17 | Greenwood | 23,222 | 0.4% |
| 18 | Mauldin | 22,889 | 3.9% |
| 19 | North Augusta | 21,348 | 1.9% |
| 20 | Easley | 19,993 | 1.0% |
| 21 | Simpsonville | 18,238 | 2.1% |
| 22 | Hanahan | 17,997 | 3.3% |
| 23 | Lexington | 17,870 | 5.3% |
| 24 | Conway | 17,103 | 3.0% |
| 25 | West Columbia | 14,988 | 1.2% |
| 26 | Orangeburg | 13,964 | 0.8% |
| 27 | Clemson | 13,905 | 1.6% |
| 28 | North Myrtle Beach | 13,752 | 2.0% |
| 29 | Bluffton | 12,530 | 18.5% |
| 30 | Cayce | 12,528 | 0.3% |
| 31 | Gaffney | 12,414 | -0.4% |
| 32 | Beaufort | 12,361 | -0.3% |
| 33 | Irmo | 11,097 | -0.1% |
| 34 | Fort Mill | 10,811 | 3.0% |
| 35 | Port Royal | 10,678 | 1.3% |
| 36 | Forest Acres | 10,361 | -0.1% |
| 37 | Newberry | 10,277 | -0.1% |
| 38 | Georgetown | 9,163 | 0.2% |
| 39 | Laurens | 9,139 | -0.6% |
| 40 | Bennettsville | 9,069 | -0.5% |
| 41 | Lancaster | 8,526 | 0.3% |
| 42 | Clinton | 8,490 | -0.7% |
| 43 | Union | 8,393 | -0.5% |
| 44 | Seneca | 8,102 | 0.5% |
| 45 | Moncks Corner | 7,885 | 2.4% |
| 46 | Fountain Inn | 7,799 | 2.3% |
| 47 | Hartsville | 7,764 | 0.3% |
| 48 | York | 7,736 | 1.0% |
| 49 | Tega Cay | 7,620 | 6.0% |
| 50 | Marion | 6,939 | -0.1% |
| 51 | Camden | 6,838 | 0.2% |
| 52 | Dillon | 6,788 | 0.4% |
| 53 | Lake City | 6,675 | 0.3% |
| 54 | Darlington | 6,289 | -0.8% |
| 55 | Cheraw | 5,851 | 0.5% |
| 56 | Chester | 5,607 | -1.4% |
| 57 | Walterboro | 5,398 | 0.1% |
| 58 | Batesburg-Leesville | 5,362 | -0.3% |
| 59 | Abbeville | 5,237 | -1.1% |
| 60 | Central | 5,159 | 3.5% |
| 61 | Clover | 5,094 | 2.4% |
| 62 | Barnwell | 4,750 | -0.4% |
| 63 | Edgefield | 4,750 | 0.7% |
| 64 | Hollywood | 4,714 | 1.3% |
| 65 | Mullins | 4,663 | -0.7% |
| 66 | Travelers Rest | 4,576 | 1.2% |
| 67 | Walhalla | 4,263 | 1.1% |
| 68 | Belton | 4,134 | -0.8% |
| 69 | Isle of Palms | 4,133 | -1.0% |
| 70 | Manning | 4,108 | 0.2% |
| 71 | Woodruff | 4,090 | -0.4% |
| 72 | Ridgeland | 4,036 | 4.4% |
| 73 | Williamston | 3,934 | 0.3% |
| 74 | Surfside Beach | 3,837 | -1.4% |
| 75 | Bamberg | 3,607 | -0.3% |
| 76 | Honea Path | 3,597 | 0.2% |
| 77 | Saluda | 3,565 | 1.5% |
| 78 | Winnsboro | 3,550 | -0.7% |
| 79 | Denmark | 3,538 | 0.7% |
| 80 | Allendale | 3,482 | -1.5% |
| 81 | Bishopville | 3,471 | -0.6% |
| 82 | Kingstree | 3,328 | -0.8% |
| 83 | Liberty | 3,269 | 0.8% |
| 84 | Lyman | 3,243 | 1.4% |
| 85 | Duncan | 3,181 | 0.7% |
| 86 | Williston | 3,139 | -0.4% |
| 87 | Pickens | 3,126 | 0.3% |
| 88 | Pendleton | 2,964 | -0.1% |
| 89 | Hardeeville | 2,952 | 3.4% |
| 90 | Andrews | 2,861 | -0.7% |
| 91 | Hampton | 2,808 | -0.1% |
| 92 | McCormick | 2,783 | 0.4% |
| 93 | Pageland | 2,760 | 0.9% |
| 94 | Burnettown | 2,673 | 0.2% |
| 95 | Springdale | 2,636 | -0.0% |
| 96 | Folly Beach | 2,617 | 1.8% |
| 97 | Ravenel | 2,465 | 0.5% |
| 98 | Westminster | 2,418 | -1.3% |
| 99 | Blackville | 2,406 | -2.1% |
| 100 | Loris | 2,396 | 1.4% |
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