| Rank | City | 2022 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 151,612 | 0.5% |
| 2 | Columbia | 137,541 | 0.2% |
| 3 | North Charleston | 117,472 | 1.5% |
| 4 | Mount Pleasant | 92,398 | 1.7% |
| 5 | Rock Hill | 74,102 | -0.1% |
| 6 | Greenville | 72,095 | 1.7% |
| 7 | Summerville | 51,216 | 0.4% |
| 8 | Goose Creek | 46,229 | 0.9% |
| 9 | Sumter | 42,976 | -0.8% |
| 10 | Florence | 39,958 | 0.1% |
| 11 | Greer | 38,865 | 8.6% |
| 12 | Spartanburg | 38,401 | -0.3% |
| 13 | Hilton Head Island | 38,076 | 0.0% |
| 14 | Myrtle Beach | 37,100 | 2.7% |
| 15 | Bluffton | 32,191 | 12.0% |
| 16 | Aiken | 31,895 | 0.3% |
| 17 | Anderson | 29,284 | 0.4% |
| 18 | Fort Mill | 27,991 | 10.8% |
| 19 | Mauldin | 25,654 | 3.6% |
| 20 | Simpsonville | 24,685 | 4.7% |
| 21 | North Augusta | 24,675 | 1.1% |
| 22 | Lexington | 24,208 | 2.8% |
| 23 | Easley | 23,422 | 1.6% |
| 24 | Conway | 23,119 | 2.4% |
| 25 | Greenwood | 22,221 | -0.3% |
| 26 | Hanahan | 21,480 | 3.9% |
| 27 | North Myrtle Beach | 19,485 | 2.1% |
| 28 | Clemson | 17,986 | 1.0% |
| 29 | West Columbia | 17,466 | 0.7% |
| 30 | Cayce | 13,739 | -0.2% |
| 31 | Moncks Corner | 13,644 | 1.9% |
| 32 | Tega Cay | 13,278 | 2.5% |
| 33 | Port Royal | 13,169 | 2.0% |
| 34 | Beaufort | 12,960 | 0.3% |
| 35 | Orangeburg | 12,482 | -1.4% |
| 36 | Gaffney | 12,424 | -1.1% |
| 37 | Irmo | 11,758 | 1.5% |
| 38 | James Island | 11,602 | -0.1% |
| 39 | Fountain Inn | 10,995 | 4.8% |
| 40 | Forest Acres | 10,560 | -0.4% |
| 41 | Newberry | 10,487 | 0.2% |
| 42 | Laurens | 9,319 | -0.1% |
| 43 | Seneca | 8,900 | 0.7% |
| 44 | Hardeeville | 8,835 | 14.3% |
| 45 | York | 8,615 | 1.0% |
| 46 | Lancaster | 8,575 | 1.2% |
| 47 | Georgetown | 8,333 | -0.1% |
| 48 | Union | 8,054 | -1.0% |
| 49 | Camden | 7,907 | 1.7% |
| 50 | Travelers Rest | 7,771 | 0.8% |
| 51 | Clinton | 7,694 | -0.4% |
| 52 | Hartsville | 7,588 | 0.3% |
| 53 | Bennettsville | 6,955 | -0.9% |
| 54 | Clover | 6,949 | 2.9% |
| 55 | Lyman | 6,321 | 1.8% |
| 56 | Marion | 6,314 | -1.3% |
| 57 | Dillon | 6,282 | -1.1% |
| 58 | Darlington | 6,092 | -0.7% |
| 59 | Lake City | 5,929 | 0.3% |
| 60 | Walterboro | 5,463 | -0.6% |
| 61 | Hollywood | 5,392 | 0.2% |
| 62 | Blythewood | 5,317 | 9.7% |
| 63 | Central | 5,296 | 0.7% |
| 64 | Batesburg-Leesville | 5,250 | -0.0% |
| 65 | Chester | 5,245 | -0.4% |
| 66 | Cheraw | 4,963 | -0.9% |
| 67 | Abbeville | 4,860 | 0.2% |
| 68 | Barnwell | 4,489 | -0.5% |
| 69 | Belton | 4,405 | 1.3% |
| 70 | Isle of Palms | 4,307 | -0.5% |
| 71 | Woodruff | 4,294 | 1.8% |
| 72 | Surfside Beach | 4,253 | 1.1% |
| 73 | Duncan | 4,151 | 2.2% |
| 74 | Williamston | 4,115 | 1.4% |
| 75 | Walhalla | 4,095 | 0.6% |
| 76 | Mullins | 3,935 | -1.3% |
| 77 | Manning | 3,859 | -0.7% |
| 78 | Honea Path | 3,741 | 1.4% |
| 79 | Ridgeland | 3,683 | -0.1% |
| 80 | Pendleton | 3,553 | 1.5% |
| 81 | Wellford | 3,415 | 1.8% |
| 82 | Pickens | 3,371 | -0.2% |
| 83 | Liberty | 3,344 | -1.0% |
| 84 | Kingstree | 3,181 | -1.9% |
| 85 | Winnsboro | 3,163 | -1.2% |
| 86 | Burnettown | 3,150 | 1.0% |
| 87 | Denmark | 3,139 | -0.5% |
| 88 | Saluda | 3,069 | -1.4% |
| 89 | Inman | 3,054 | 1.9% |
| 90 | Bamberg | 3,040 | -0.7% |
| 91 | Bishopville | 2,946 | -1.6% |
| 92 | Williston | 2,879 | 0.1% |
| 93 | Hampton | 2,791 | -2.3% |
| 94 | Springdale | 2,746 | 0.1% |
| 95 | Allendale | 2,682 | -2.1% |
| 96 | Loris | 2,572 | 4.0% |
| 97 | Ravenel | 2,558 | 0.6% |
| 98 | Andrews | 2,550 | -0.9% |
| 99 | Landrum | 2,540 | 1.8% |
| 100 | Pageland | 2,443 | -0.3% |
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