| Rank | City | 2000 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 119,370 | 0.4% |
| 2 | Charleston | 99,014 | 0.9% |
| 3 | North Charleston | 81,668 | -0.4% |
| 4 | Greenville | 56,716 | -0.3% |
| 5 | Rock Hill | 50,774 | 1.7% |
| 6 | Mount Pleasant | 48,875 | 4.6% |
| 7 | Sumter | 40,643 | -0.6% |
| 8 | Spartanburg | 40,141 | -0.8% |
| 9 | Hilton Head Island | 33,973 | 3.7% |
| 10 | Goose Creek | 31,565 | 2.0% |
| 11 | Florence | 31,530 | 0.2% |
| 12 | Summerville | 28,270 | 2.5% |
| 13 | Aiken | 26,166 | 2.4% |
| 14 | Anderson | 26,001 | -0.2% |
| 15 | Myrtle Beach | 24,183 | -0.4% |
| 16 | Greenwood | 22,386 | 0.7% |
| 17 | Easley | 18,119 | 1.7% |
| 18 | Greer | 17,884 | 4.1% |
| 19 | North Augusta | 17,742 | 1.3% |
| 20 | Mauldin | 15,653 | 2.9% |
| 21 | Simpsonville | 14,840 | 2.3% |
| 22 | West Columbia | 13,366 | 0.6% |
| 23 | Hanahan | 12,994 | -0.1% |
| 24 | Gaffney | 12,954 | -0.5% |
| 25 | Orangeburg | 12,906 | -0.8% |
| 26 | Conway | 12,747 | 2.4% |
| 27 | Beaufort | 12,717 | 2.5% |
| 28 | Cayce | 12,217 | 0.5% |
| 29 | Clemson | 11,861 | 0.7% |
| 30 | North Myrtle Beach | 11,321 | 2.2% |
| 31 | Irmo | 11,260 | -0.1% |
| 32 | Lexington | 10,669 | 9.8% |
| 33 | Forest Acres | 10,429 | 0.4% |
| 34 | Newberry | 10,352 | -0.5% |
| 35 | Laurens | 9,704 | -0.4% |
| 36 | Bennettsville | 9,525 | -0.9% |
| 37 | Port Royal | 9,374 | 11.9% |
| 38 | Clinton | 9,137 | -0.8% |
| 39 | Georgetown | 9,015 | -0.7% |
| 40 | Union | 8,794 | -1.1% |
| 41 | Lancaster | 8,304 | -1.4% |
| 42 | Fort Mill | 8,034 | 4.3% |
| 43 | Seneca | 7,711 | 0.1% |
| 44 | Hartsville | 7,565 | -1.4% |
| 45 | Marion | 7,042 | -1.2% |
| 46 | York | 6,999 | 0.5% |
| 47 | Darlington | 6,796 | -1.5% |
| 48 | Camden | 6,693 | -1.0% |
| 49 | Dillon | 6,505 | -0.8% |
| 50 | Lake City | 6,477 | -1.0% |
| 51 | Chester | 6,459 | -1.2% |
| 52 | Fountain Inn | 6,239 | 3.1% |
| 53 | Moncks Corner | 6,193 | 0.7% |
| 54 | Abbeville | 5,876 | -0.7% |
| 55 | Cheraw | 5,579 | -0.9% |
| 56 | Batesburg-Leesville | 5,537 | -0.7% |
| 57 | Walterboro | 5,363 | -0.5% |
| 58 | Mullins | 5,019 | -1.7% |
| 59 | Barnwell | 4,965 | -1.1% |
| 60 | Isle of Palms | 4,576 | 2.2% |
| 61 | Belton | 4,473 | 0.1% |
| 62 | Surfside Beach | 4,440 | 0.2% |
| 63 | Edgefield | 4,433 | 4.5% |
| 64 | Woodruff | 4,261 | -0.4% |
| 65 | Tega Cay | 4,248 | 3.5% |
| 66 | Hollywood | 4,163 | 1.4% |
| 67 | Travelers Rest | 4,071 | 2.4% |
| 68 | Allendale | 4,059 | -0.9% |
| 69 | Clover | 4,036 | 1.2% |
| 70 | Manning | 4,017 | -1.8% |
| 71 | Winnsboro | 3,818 | -0.1% |
| 72 | Walhalla | 3,810 | -0.3% |
| 73 | Williamston | 3,806 | -0.8% |
| 74 | Bamberg | 3,719 | -0.3% |
| 75 | Central | 3,673 | 3.4% |
| 76 | Bishopville | 3,672 | -0.3% |
| 77 | Kingstree | 3,602 | -1.0% |
| 78 | Honea Path | 3,541 | -0.8% |
| 79 | Denmark | 3,315 | -1.5% |
| 80 | Williston | 3,283 | 0.5% |
| 81 | Fairfax | 3,200 | 3.3% |
| 82 | Saluda | 3,081 | 0.4% |
| 83 | Andrews | 3,068 | -0.1% |
| 84 | Pickens | 3,040 | -1.0% |
| 85 | Liberty | 3,012 | -1.3% |
| 86 | Pendleton | 2,988 | -1.2% |
| 87 | Duncan | 2,973 | 3.0% |
| 88 | Blackville | 2,968 | 1.5% |
| 89 | Hampton | 2,831 | -1.0% |
| 90 | Lyman | 2,815 | 1.3% |
| 91 | Westminster | 2,747 | -1.6% |
| 92 | Pacolet | 2,737 | 0.5% |
| 93 | McCormick | 2,662 | 4.8% |
| 94 | Springdale | 2,646 | -2.7% |
| 95 | Burnettown | 2,626 | 0.7% |
| 96 | Ridgeland | 2,617 | 9.3% |
| 97 | Pageland | 2,519 | -1.0% |
| 98 | McColl | 2,498 | -1.2% |
| 99 | Landrum | 2,490 | -0.8% |
| 100 | Wellford | 2,423 | 0.9% |
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