| Rank | City | 2019 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 136,208 | 1.6% |
| 2 | Columbia | 133,451 | 0.4% |
| 3 | North Charleston | 113,237 | 1.9% |
| 4 | Mount Pleasant | 89,338 | 3.5% |
| 5 | Rock Hill | 74,309 | 1.5% |
| 6 | Greenville | 68,563 | 2.0% |
| 7 | Summerville | 51,692 | 2.2% |
| 8 | Goose Creek | 42,841 | 2.2% |
| 9 | Sumter | 39,656 | -0.3% |
| 10 | Hilton Head Island | 39,639 | 0.8% |
| 11 | Spartanburg | 37,644 | 0.2% |
| 12 | Florence | 37,625 | 0.2% |
| 13 | Myrtle Beach | 33,908 | 2.8% |
| 14 | Greer | 32,102 | 2.9% |
| 15 | Aiken | 30,778 | 0.5% |
| 16 | Anderson | 27,380 | 0.3% |
| 17 | Hanahan | 25,765 | 4.6% |
| 18 | Mauldin | 25,193 | 1.2% |
| 19 | Conway | 24,980 | 4.8% |
| 20 | North Augusta | 23,584 | 1.3% |
| 21 | Greenwood | 23,407 | 0.1% |
| 22 | Bluffton | 23,097 | 7.9% |
| 23 | Simpsonville | 23,037 | 3.0% |
| 24 | Lexington | 21,737 | 2.5% |
| 25 | Easley | 21,240 | 0.8% |
| 26 | Fort Mill | 19,848 | 7.9% |
| 27 | West Columbia | 17,821 | 2.2% |
| 28 | Clemson | 17,102 | 2.6% |
| 29 | North Myrtle Beach | 16,573 | 2.4% |
| 30 | Cayce | 14,081 | 1.5% |
| 31 | Beaufort | 13,357 | 1.0% |
| 32 | Port Royal | 13,037 | 2.5% |
| 33 | Orangeburg | 12,903 | -1.0% |
| 34 | Gaffney | 12,507 | 0.1% |
| 35 | Irmo | 12,357 | 1.4% |
| 36 | James Island | 12,068 | – |
| 37 | Moncks Corner | 11,419 | 4.7% |
| 38 | Tega Cay | 10,863 | 4.5% |
| 39 | Newberry | 10,337 | 0.1% |
| 40 | Forest Acres | 10,331 | -0.0% |
| 41 | Fountain Inn | 10,019 | 3.2% |
| 42 | Lancaster | 9,175 | 0.9% |
| 43 | Laurens | 8,846 | -0.4% |
| 44 | Georgetown | 8,779 | -0.5% |
| 45 | Seneca | 8,479 | 0.6% |
| 46 | Clinton | 8,426 | -0.1% |
| 47 | York | 8,235 | 0.8% |
| 48 | Bennettsville | 7,868 | -1.8% |
| 49 | Union | 7,764 | -1.0% |
| 50 | Hartsville | 7,549 | -0.4% |
| 51 | Camden | 7,196 | 0.6% |
| 52 | Lake City | 6,557 | -0.2% |
| 53 | Hardeeville | 6,515 | 10.4% |
| 54 | Marion | 6,427 | -1.0% |
| 55 | Clover | 6,397 | 2.9% |
| 56 | Dillon | 6,367 | -0.8% |
| 57 | Darlington | 5,928 | -0.7% |
| 58 | Cheraw | 5,619 | -0.5% |
| 59 | Walterboro | 5,468 | 0.2% |
| 60 | Chester | 5,393 | -0.5% |
| 61 | Batesburg-Leesville | 5,385 | 0.1% |
| 62 | Central | 5,359 | 0.5% |
| 63 | Travelers Rest | 5,253 | 1.7% |
| 64 | Hollywood | 5,180 | 1.2% |
| 65 | Abbeville | 5,043 | -0.5% |
| 66 | Edgefield | 4,769 | 0.0% |
| 67 | Surfside Beach | 4,468 | 1.9% |
| 68 | Belton | 4,402 | 0.8% |
| 69 | Barnwell | 4,367 | -1.0% |
| 70 | Walhalla | 4,367 | 0.3% |
| 71 | Isle of Palms | 4,340 | 0.6% |
| 72 | Mullins | 4,329 | -0.9% |
| 73 | Woodruff | 4,325 | 0.7% |
| 74 | Williamston | 4,216 | 0.9% |
| 75 | Manning | 3,941 | -0.5% |
| 76 | Ridgeland | 3,831 | -0.6% |
| 77 | Honea Path | 3,781 | 0.6% |
| 78 | Blythewood | 3,778 | 8.0% |
| 79 | Saluda | 3,632 | 0.2% |
| 80 | Lyman | 3,615 | 1.4% |
| 81 | Duncan | 3,525 | 1.3% |
| 82 | Bamberg | 3,237 | -1.3% |
| 83 | Pendleton | 3,228 | 1.1% |
| 84 | Winnsboro | 3,204 | -1.3% |
| 85 | Pickens | 3,164 | 0.2% |
| 86 | Liberty | 3,163 | -0.4% |
| 87 | Kingstree | 3,058 | -1.1% |
| 88 | Denmark | 2,984 | -2.1% |
| 89 | Bishopville | 2,983 | -1.9% |
| 90 | Allendale | 2,979 | -1.9% |
| 91 | Williston | 2,932 | -0.8% |
| 92 | Andrews | 2,852 | -0.0% |
| 93 | Springdale | 2,739 | 0.5% |
| 94 | Burnettown | 2,736 | 0.3% |
| 95 | Loris | 2,700 | 1.5% |
| 96 | Ravenel | 2,674 | 1.0% |
| 97 | Pageland | 2,668 | -0.4% |
| 98 | Wellford | 2,664 | 1.4% |
| 99 | Folly Beach | 2,641 | 0.1% |
| 100 | Landrum | 2,625 | 1.3% |
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