| Rank | City | 2018 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 134,875 | 1.7% |
| 2 | Columbia | 133,114 | 0.4% |
| 3 | North Charleston | 110,861 | 1.9% |
| 4 | Mount Pleasant | 86,668 | 3.6% |
| 5 | Rock Hill | 73,068 | 1.4% |
| 6 | Greenville | 68,219 | 2.2% |
| 7 | Summerville | 50,388 | 2.2% |
| 8 | Goose Creek | 42,619 | 2.5% |
| 9 | Hilton Head Island | 40,055 | 1.1% |
| 10 | Sumter | 39,982 | -0.2% |
| 11 | Florence | 37,778 | 0.3% |
| 12 | Spartanburg | 37,498 | 0.2% |
| 13 | Myrtle Beach | 32,795 | 2.8% |
| 14 | Greer | 30,899 | 2.8% |
| 15 | Aiken | 30,721 | 0.6% |
| 16 | Anderson | 27,293 | 0.3% |
| 17 | Mauldin | 25,130 | 1.3% |
| 18 | Hanahan | 24,885 | 4.7% |
| 19 | Conway | 23,714 | 4.8% |
| 20 | Greenwood | 23,262 | 0.0% |
| 21 | North Augusta | 22,930 | 1.0% |
| 22 | Simpsonville | 22,072 | 2.8% |
| 23 | Lexington | 21,265 | 2.5% |
| 24 | Bluffton | 21,085 | 7.7% |
| 25 | Easley | 21,053 | 0.7% |
| 26 | Fort Mill | 17,557 | 7.2% |
| 27 | West Columbia | 17,265 | 2.0% |
| 28 | Clemson | 16,649 | 2.6% |
| 29 | North Myrtle Beach | 16,310 | 2.5% |
| 30 | Cayce | 14,086 | 1.7% |
| 31 | Beaufort | 13,729 | 1.5% |
| 32 | Orangeburg | 12,954 | -1.1% |
| 33 | Port Royal | 12,886 | 2.7% |
| 34 | Gaffney | 12,782 | 0.4% |
| 35 | Irmo | 12,250 | 1.4% |
| 36 | James Island | 12,083 | – |
| 37 | Moncks Corner | 10,933 | 4.8% |
| 38 | Forest Acres | 10,380 | 0.0% |
| 39 | Tega Cay | 10,339 | 4.5% |
| 40 | Newberry | 10,302 | 0.0% |
| 41 | Lancaster | 8,976 | 0.7% |
| 42 | Laurens | 8,887 | -0.4% |
| 43 | Georgetown | 8,860 | -0.5% |
| 44 | Fountain Inn | 8,688 | 1.6% |
| 45 | Clinton | 8,503 | 0.0% |
| 46 | Seneca | 8,340 | 0.4% |
| 47 | York | 8,147 | 0.7% |
| 48 | Bennettsville | 8,038 | -1.7% |
| 49 | Union | 7,821 | -1.0% |
| 50 | Hartsville | 7,626 | -0.3% |
| 51 | Camden | 7,168 | 0.7% |
| 52 | Lake City | 6,670 | -0.0% |
| 53 | Marion | 6,472 | -1.0% |
| 54 | Dillon | 6,444 | -0.7% |
| 55 | Clover | 6,085 | 2.6% |
| 56 | Darlington | 5,999 | -0.7% |
| 57 | Hardeeville | 5,967 | 10.6% |
| 58 | Cheraw | 5,639 | -0.5% |
| 59 | Chester | 5,420 | -0.5% |
| 60 | Batesburg-Leesville | 5,377 | 0.0% |
| 61 | Hollywood | 5,179 | 1.4% |
| 62 | Central | 5,179 | 0.1% |
| 63 | Walterboro | 5,121 | -0.7% |
| 64 | Travelers Rest | 5,108 | 1.6% |
| 65 | Abbeville | 5,083 | -0.4% |
| 66 | Edgefield | 4,755 | 0.0% |
| 67 | Barnwell | 4,429 | -1.0% |
| 68 | Surfside Beach | 4,422 | 2.0% |
| 69 | Mullins | 4,387 | -0.9% |
| 70 | Belton | 4,370 | 0.8% |
| 71 | Isle of Palms | 4,363 | 0.8% |
| 72 | Walhalla | 4,315 | 0.2% |
| 73 | Woodruff | 4,232 | 0.5% |
| 74 | Williamston | 4,183 | 0.9% |
| 75 | Ridgeland | 4,067 | 0.1% |
| 76 | Manning | 3,977 | -0.5% |
| 77 | Honea Path | 3,754 | 0.6% |
| 78 | Saluda | 3,627 | 0.2% |
| 79 | Lyman | 3,518 | 1.2% |
| 80 | Duncan | 3,439 | 1.1% |
| 81 | Blythewood | 3,429 | 7.7% |
| 82 | Bamberg | 3,282 | -1.3% |
| 83 | Winnsboro | 3,237 | -1.3% |
| 84 | Pendleton | 3,197 | 1.1% |
| 85 | Liberty | 3,174 | -0.4% |
| 86 | Pickens | 3,164 | 0.2% |
| 87 | Bishopville | 3,134 | -1.4% |
| 88 | Kingstree | 3,096 | -1.0% |
| 89 | Allendale | 3,027 | -2.0% |
| 90 | Denmark | 2,968 | -2.5% |
| 91 | Williston | 2,965 | -0.8% |
| 92 | Andrews | 2,876 | 0.1% |
| 93 | Burnettown | 2,808 | 0.7% |
| 94 | Springdale | 2,744 | 0.6% |
| 95 | Folly Beach | 2,726 | 0.6% |
| 96 | Pageland | 2,683 | -0.4% |
| 97 | Loris | 2,680 | 1.6% |
| 98 | Ravenel | 2,669 | 1.1% |
| 99 | Wellford | 2,601 | 1.3% |
| 100 | Hampton | 2,560 | -1.3% |
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