| Rank | City | 2017 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Charleston | 134,385 | 1.9% |
| 2 | Columbia | 134,309 | 0.6% |
| 3 | North Charleston | 109,298 | 1.9% |
| 4 | Mount Pleasant | 84,170 | 3.7% |
| 5 | Rock Hill | 72,937 | 1.6% |
| 6 | Greenville | 67,453 | 2.4% |
| 7 | Summerville | 49,323 | 2.2% |
| 8 | Goose Creek | 42,039 | 2.6% |
| 9 | Sumter | 40,723 | 0.1% |
| 10 | Hilton Head Island | 40,500 | 1.5% |
| 11 | Florence | 38,317 | 0.6% |
| 12 | Spartanburg | 37,876 | 0.4% |
| 13 | Myrtle Beach | 32,240 | 2.9% |
| 14 | Aiken | 30,937 | 0.8% |
| 15 | Greer | 29,000 | 2.2% |
| 16 | Anderson | 27,544 | 0.5% |
| 17 | Mauldin | 25,188 | 1.6% |
| 18 | Hanahan | 23,439 | 4.5% |
| 19 | Greenwood | 23,320 | 0.1% |
| 20 | North Augusta | 22,932 | 1.2% |
| 21 | Conway | 22,761 | 4.9% |
| 22 | Simpsonville | 21,314 | 2.6% |
| 23 | Lexington | 20,988 | 2.7% |
| 24 | Easley | 20,953 | 0.8% |
| 25 | Bluffton | 18,897 | 7.1% |
| 26 | West Columbia | 16,282 | 1.4% |
| 27 | Clemson | 16,058 | 2.4% |
| 28 | North Myrtle Beach | 16,032 | 2.6% |
| 29 | Fort Mill | 15,029 | 5.6% |
| 30 | Cayce | 14,233 | 2.1% |
| 31 | Beaufort | 13,445 | 1.4% |
| 32 | Orangeburg | 13,196 | -0.9% |
| 33 | Gaffney | 12,920 | 0.7% |
| 34 | Port Royal | 12,785 | 3.0% |
| 35 | Irmo | 12,177 | 1.6% |
| 36 | James Island | 12,166 | – |
| 37 | Forest Acres | 10,542 | 0.3% |
| 38 | Newberry | 10,372 | 0.2% |
| 39 | Moncks Corner | 10,315 | 4.6% |
| 40 | Tega Cay | 9,946 | 4.5% |
| 41 | Lancaster | 9,134 | 1.2% |
| 42 | Laurens | 9,080 | -0.1% |
| 43 | Georgetown | 9,024 | -0.3% |
| 44 | Fountain Inn | 8,513 | 1.5% |
| 45 | Clinton | 8,453 | -0.1% |
| 46 | Seneca | 8,352 | 0.5% |
| 47 | Bennettsville | 8,255 | -1.6% |
| 48 | York | 8,058 | 0.7% |
| 49 | Union | 8,000 | -0.8% |
| 50 | Hartsville | 7,768 | 0.0% |
| 51 | Camden | 7,126 | 0.7% |
| 52 | Lake City | 6,761 | 0.2% |
| 53 | Marion | 6,711 | -0.6% |
| 54 | Dillon | 6,604 | -0.5% |
| 55 | Darlington | 6,117 | -0.5% |
| 56 | Clover | 5,950 | 2.6% |
| 57 | Cheraw | 5,780 | -0.2% |
| 58 | Hardeeville | 5,721 | 11.7% |
| 59 | Chester | 5,474 | -0.4% |
| 60 | Batesburg-Leesville | 5,448 | 0.3% |
| 61 | Walterboro | 5,293 | -0.3% |
| 62 | Central | 5,229 | 0.2% |
| 63 | Abbeville | 5,168 | -0.2% |
| 64 | Hollywood | 5,084 | 1.3% |
| 65 | Travelers Rest | 5,053 | 1.7% |
| 66 | Edgefield | 4,752 | 0.0% |
| 67 | Barnwell | 4,542 | -0.7% |
| 68 | Mullins | 4,524 | -0.5% |
| 69 | Isle of Palms | 4,395 | 1.0% |
| 70 | Surfside Beach | 4,391 | 2.3% |
| 71 | Belton | 4,386 | 1.0% |
| 72 | Walhalla | 4,318 | 0.2% |
| 73 | Woodruff | 4,191 | 0.4% |
| 74 | Williamston | 4,190 | 1.1% |
| 75 | Ridgeland | 4,141 | 0.4% |
| 76 | Manning | 4,042 | -0.3% |
| 77 | Honea Path | 3,747 | 0.7% |
| 78 | Saluda | 3,617 | 0.2% |
| 79 | Lyman | 3,476 | 1.2% |
| 80 | Duncan | 3,369 | 1.0% |
| 81 | Bamberg | 3,342 | -1.3% |
| 82 | Winnsboro | 3,311 | -1.2% |
| 83 | Liberty | 3,252 | -0.1% |
| 84 | Bishopville | 3,238 | -1.2% |
| 85 | Kingstree | 3,221 | -0.5% |
| 86 | Pickens | 3,190 | 0.3% |
| 87 | Pendleton | 3,184 | 1.2% |
| 88 | Blythewood | 3,099 | 7.3% |
| 89 | Allendale | 3,046 | -2.2% |
| 90 | Denmark | 3,019 | -2.6% |
| 91 | Williston | 2,998 | -0.8% |
| 92 | Andrews | 2,896 | 0.2% |
| 93 | Burnettown | 2,800 | 0.8% |
| 94 | Springdale | 2,791 | 1.0% |
| 95 | Folly Beach | 2,782 | 1.0% |
| 96 | Pageland | 2,704 | -0.3% |
| 97 | Loris | 2,651 | 1.7% |
| 98 | Hampton | 2,639 | -1.0% |
| 99 | Ravenel | 2,628 | 1.1% |
| 100 | Wellford | 2,563 | 1.3% |
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