| Rank | City | 2016 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 133,803 | 0.7% |
| 2 | Charleston | 132,609 | 2.0% |
| 3 | North Charleston | 108,304 | 2.1% |
| 4 | Mount Pleasant | 81,317 | 3.7% |
| 5 | Rock Hill | 71,548 | 1.6% |
| 6 | Greenville | 64,579 | 2.0% |
| 7 | Summerville | 48,848 | 2.4% |
| 8 | Sumter | 40,816 | 0.1% |
| 9 | Goose Creek | 40,633 | 2.5% |
| 10 | Hilton Head Island | 40,512 | 1.8% |
| 11 | Florence | 38,228 | 0.6% |
| 12 | Spartanburg | 37,867 | 0.5% |
| 13 | Myrtle Beach | 31,035 | 2.7% |
| 14 | Aiken | 30,604 | 0.7% |
| 15 | Greer | 28,365 | 2.1% |
| 16 | Anderson | 27,335 | 0.5% |
| 17 | Mauldin | 25,135 | 1.9% |
| 18 | Greenwood | 23,260 | 0.0% |
| 19 | North Augusta | 22,522 | 1.1% |
| 20 | Hanahan | 21,575 | 3.7% |
| 21 | Conway | 21,053 | 4.2% |
| 22 | Easley | 20,765 | 0.8% |
| 23 | Simpsonville | 20,736 | 2.6% |
| 24 | Lexington | 20,138 | 2.4% |
| 25 | Bluffton | 16,728 | 5.9% |
| 26 | West Columbia | 16,060 | 1.4% |
| 27 | North Myrtle Beach | 15,579 | 2.5% |
| 28 | Clemson | 15,446 | 2.1% |
| 29 | Fort Mill | 13,662 | 4.8% |
| 30 | Cayce | 13,619 | 1.7% |
| 31 | Orangeburg | 13,460 | -0.7% |
| 32 | Beaufort | 13,306 | 1.5% |
| 33 | Gaffney | 12,566 | 0.2% |
| 34 | Port Royal | 12,122 | 2.6% |
| 35 | Irmo | 12,056 | 1.7% |
| 36 | James Island | 11,789 | – |
| 37 | Forest Acres | 10,615 | 0.5% |
| 38 | Newberry | 10,331 | 0.1% |
| 39 | Moncks Corner | 9,873 | 4.6% |
| 40 | Tega Cay | 9,608 | 4.7% |
| 41 | Laurens | 9,166 | 0.1% |
| 42 | Georgetown | 9,062 | -0.2% |
| 43 | Lancaster | 8,956 | 1.0% |
| 44 | Clinton | 8,637 | 0.3% |
| 45 | Bennettsville | 8,605 | -1.0% |
| 46 | Fountain Inn | 8,317 | 1.3% |
| 47 | Seneca | 8,279 | 0.4% |
| 48 | Union | 8,045 | -0.8% |
| 49 | York | 8,009 | 0.7% |
| 50 | Hartsville | 7,826 | 0.2% |
| 51 | Camden | 7,085 | 0.7% |
| 52 | Lake City | 6,788 | 0.3% |
| 53 | Marion | 6,714 | -0.7% |
| 54 | Dillon | 6,677 | -0.3% |
| 55 | Darlington | 6,155 | -0.4% |
| 56 | Cheraw | 5,778 | -0.3% |
| 57 | Clover | 5,744 | 2.4% |
| 58 | Chester | 5,486 | -0.4% |
| 59 | Batesburg-Leesville | 5,441 | 0.3% |
| 60 | Hardeeville | 5,301 | 12.4% |
| 61 | Walterboro | 5,278 | -0.4% |
| 62 | Abbeville | 5,191 | -0.2% |
| 63 | Central | 5,167 | 0.0% |
| 64 | Travelers Rest | 4,994 | 1.8% |
| 65 | Hollywood | 4,962 | 1.0% |
| 66 | Edgefield | 4,760 | 0.0% |
| 67 | Barnwell | 4,592 | -0.7% |
| 68 | Mullins | 4,519 | -0.6% |
| 69 | Isle of Palms | 4,371 | 1.1% |
| 70 | Belton | 4,336 | 1.0% |
| 71 | Surfside Beach | 4,280 | 2.2% |
| 72 | Walhalla | 4,251 | -0.1% |
| 73 | Woodruff | 4,129 | 0.2% |
| 74 | Williamston | 4,124 | 0.9% |
| 75 | Manning | 4,037 | -0.3% |
| 76 | Ridgeland | 3,999 | -0.2% |
| 77 | Honea Path | 3,707 | 0.6% |
| 78 | Saluda | 3,596 | 0.2% |
| 79 | Lyman | 3,423 | 1.1% |
| 80 | Bamberg | 3,383 | -1.3% |
| 81 | Winnsboro | 3,351 | -1.1% |
| 82 | Duncan | 3,317 | 0.8% |
| 83 | Denmark | 3,315 | -1.3% |
| 84 | Bishopville | 3,274 | -1.2% |
| 85 | Liberty | 3,246 | -0.1% |
| 86 | Kingstree | 3,183 | -0.9% |
| 87 | Pickens | 3,173 | 0.3% |
| 88 | Pendleton | 3,152 | 1.2% |
| 89 | Allendale | 3,126 | -2.1% |
| 90 | Williston | 3,028 | -0.7% |
| 91 | Andrews | 2,888 | 0.2% |
| 92 | Springdale | 2,783 | 1.1% |
| 93 | Blythewood | 2,782 | 6.5% |
| 94 | Burnettown | 2,777 | 0.8% |
| 95 | Folly Beach | 2,774 | 1.2% |
| 96 | Pageland | 2,746 | -0.1% |
| 97 | Hampton | 2,664 | -1.0% |
| 98 | Ravenel | 2,600 | 1.1% |
| 99 | Loris | 2,591 | 1.6% |
| 100 | McCormick | 2,578 | -1.5% |
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