| Rank | City | 2015 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 132,067 | 0.5% |
| 2 | Charleston | 130,113 | 2.0% |
| 3 | North Charleston | 106,749 | 2.3% |
| 4 | Mount Pleasant | 77,796 | 3.5% |
| 5 | Rock Hill | 69,967 | 1.4% |
| 6 | Greenville | 62,252 | 1.6% |
| 7 | Summerville | 46,974 | 2.0% |
| 8 | Sumter | 40,929 | 0.2% |
| 9 | Goose Creek | 40,370 | 2.9% |
| 10 | Hilton Head Island | 40,039 | 1.9% |
| 11 | Florence | 37,961 | 0.6% |
| 12 | Spartanburg | 37,525 | 0.3% |
| 13 | Aiken | 30,258 | 0.6% |
| 14 | Myrtle Beach | 29,992 | 2.6% |
| 15 | Greer | 27,676 | 2.1% |
| 16 | Anderson | 27,181 | 0.5% |
| 17 | Mauldin | 24,823 | 2.0% |
| 18 | Greenwood | 23,236 | 0.0% |
| 19 | North Augusta | 22,300 | 1.1% |
| 20 | Easley | 20,549 | 0.7% |
| 21 | Conway | 20,175 | 4.2% |
| 22 | Simpsonville | 20,125 | 2.5% |
| 23 | Lexington | 19,893 | 2.7% |
| 24 | Hanahan | 19,865 | 2.5% |
| 25 | West Columbia | 15,920 | 1.5% |
| 26 | Bluffton | 15,199 | 4.9% |
| 27 | North Myrtle Beach | 15,174 | 2.5% |
| 28 | Clemson | 15,072 | 2.0% |
| 29 | Orangeburg | 13,553 | -0.7% |
| 30 | Beaufort | 13,130 | 1.5% |
| 31 | Fort Mill | 13,087 | 4.9% |
| 32 | Cayce | 12,951 | 0.8% |
| 33 | Gaffney | 12,597 | 0.4% |
| 34 | Irmo | 11,893 | 1.7% |
| 35 | Port Royal | 11,870 | 2.7% |
| 36 | James Island | 11,630 | – |
| 37 | Forest Acres | 10,603 | 0.6% |
| 38 | Newberry | 10,268 | -0.0% |
| 39 | Moncks Corner | 9,460 | 4.7% |
| 40 | Laurens | 9,182 | 0.1% |
| 41 | Tega Cay | 9,120 | 4.6% |
| 42 | Georgetown | 9,054 | -0.3% |
| 43 | Lancaster | 8,960 | 1.2% |
| 44 | Bennettsville | 8,833 | -0.7% |
| 45 | Clinton | 8,619 | 0.4% |
| 46 | Seneca | 8,246 | 0.4% |
| 47 | Fountain Inn | 8,134 | 1.1% |
| 48 | Union | 8,041 | -1.1% |
| 49 | York | 8,038 | 1.0% |
| 50 | Hartsville | 7,852 | 0.3% |
| 51 | Camden | 7,030 | 0.7% |
| 52 | Marion | 6,751 | -0.7% |
| 53 | Lake City | 6,732 | 0.2% |
| 54 | Dillon | 6,658 | -0.5% |
| 55 | Darlington | 6,206 | -0.3% |
| 56 | Cheraw | 5,793 | -0.2% |
| 57 | Clover | 5,579 | 2.3% |
| 58 | Chester | 5,494 | -0.5% |
| 59 | Batesburg-Leesville | 5,423 | 0.3% |
| 60 | Walterboro | 5,281 | -0.5% |
| 61 | Abbeville | 5,191 | -0.2% |
| 62 | Central | 5,149 | -0.0% |
| 63 | Travelers Rest | 4,916 | 1.8% |
| 64 | Hollywood | 4,904 | 1.0% |
| 65 | Hardeeville | 4,789 | 12.9% |
| 66 | Edgefield | 4,718 | -0.2% |
| 67 | Barnwell | 4,649 | -0.5% |
| 68 | Mullins | 4,534 | -0.7% |
| 69 | Isle of Palms | 4,319 | 1.1% |
| 70 | Belton | 4,289 | 0.9% |
| 71 | Walhalla | 4,218 | -0.3% |
| 72 | Surfside Beach | 4,187 | 2.2% |
| 73 | Woodruff | 4,111 | 0.1% |
| 74 | Ridgeland | 4,076 | 0.2% |
| 75 | Williamston | 4,072 | 0.9% |
| 76 | Manning | 4,059 | -0.3% |
| 77 | Honea Path | 3,670 | 0.5% |
| 78 | Saluda | 3,607 | 0.3% |
| 79 | Bamberg | 3,453 | -1.1% |
| 80 | Winnsboro | 3,384 | -1.2% |
| 81 | Lyman | 3,375 | 1.0% |
| 82 | Denmark | 3,372 | -1.2% |
| 83 | Bishopville | 3,300 | -1.3% |
| 84 | Duncan | 3,269 | 0.7% |
| 85 | Liberty | 3,235 | -0.3% |
| 86 | Allendale | 3,195 | -2.1% |
| 87 | Kingstree | 3,185 | -1.1% |
| 88 | Pickens | 3,149 | 0.2% |
| 89 | Pendleton | 3,115 | 1.2% |
| 90 | Williston | 3,054 | -0.7% |
| 91 | Andrews | 2,862 | 0.0% |
| 92 | Burnettown | 2,764 | 0.8% |
| 93 | Springdale | 2,747 | 1.0% |
| 94 | Pageland | 2,744 | -0.1% |
| 95 | Folly Beach | 2,739 | 1.1% |
| 96 | McCormick | 2,704 | -0.7% |
| 97 | Hampton | 2,702 | -1.0% |
| 98 | Ravenel | 2,571 | 1.1% |
| 99 | Loris | 2,538 | 1.4% |
| 100 | Wellford | 2,519 | 1.5% |
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