| Rank | City | 2014 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 133,358 | 1.0% |
| 2 | Charleston | 127,999 | 2.2% |
| 3 | North Charleston | 104,054 | 2.2% |
| 4 | Mount Pleasant | 74,885 | 3.3% |
| 5 | Rock Hill | 69,103 | 1.5% |
| 6 | Greenville | 61,397 | 1.7% |
| 7 | Summerville | 46,074 | 2.0% |
| 8 | Sumter | 41,190 | 0.5% |
| 9 | Goose Creek | 39,823 | 3.5% |
| 10 | Hilton Head Island | 39,412 | 2.0% |
| 11 | Florence | 37,792 | 0.7% |
| 12 | Spartanburg | 37,647 | 0.6% |
| 13 | Aiken | 30,296 | 0.9% |
| 14 | Myrtle Beach | 29,175 | 2.5% |
| 15 | Greer | 27,167 | 2.1% |
| 16 | Anderson | 26,985 | 0.4% |
| 17 | Mauldin | 24,525 | 2.3% |
| 18 | Greenwood | 23,379 | 0.2% |
| 19 | North Augusta | 22,229 | 1.4% |
| 20 | Easley | 20,300 | 0.5% |
| 21 | Simpsonville | 19,615 | 2.5% |
| 22 | Hanahan | 19,597 | 2.9% |
| 23 | Lexington | 19,576 | 3.1% |
| 24 | Conway | 19,300 | 4.1% |
| 25 | West Columbia | 15,824 | 1.8% |
| 26 | North Myrtle Beach | 14,827 | 2.5% |
| 27 | Clemson | 14,276 | 0.9% |
| 28 | Orangeburg | 13,891 | -0.2% |
| 29 | Bluffton | 13,606 | 2.8% |
| 30 | Beaufort | 12,967 | 1.6% |
| 31 | Cayce | 12,860 | 0.9% |
| 32 | Gaffney | 12,657 | 0.6% |
| 33 | Fort Mill | 12,419 | 4.7% |
| 34 | Irmo | 11,742 | 1.9% |
| 35 | Port Royal | 11,542 | 2.6% |
| 36 | James Island | 11,542 | – |
| 37 | Forest Acres | 10,560 | 0.6% |
| 38 | Newberry | 10,256 | -0.1% |
| 39 | Laurens | 9,202 | 0.2% |
| 40 | Moncks Corner | 9,150 | 5.1% |
| 41 | Georgetown | 9,099 | -0.2% |
| 42 | Lancaster | 9,045 | 2.0% |
| 43 | Bennettsville | 8,864 | -0.8% |
| 44 | Clinton | 8,550 | 0.2% |
| 45 | Tega Cay | 8,445 | 3.5% |
| 46 | Seneca | 8,207 | 0.4% |
| 47 | Union | 8,148 | -1.0% |
| 48 | Fountain Inn | 7,991 | 0.8% |
| 49 | York | 7,950 | 0.9% |
| 50 | Hartsville | 7,886 | 0.5% |
| 51 | Camden | 6,973 | 0.7% |
| 52 | Marion | 6,803 | -0.7% |
| 53 | Lake City | 6,724 | 0.2% |
| 54 | Dillon | 6,701 | -0.4% |
| 55 | Darlington | 6,236 | -0.3% |
| 56 | Cheraw | 5,836 | -0.1% |
| 57 | Chester | 5,544 | -0.4% |
| 58 | Batesburg-Leesville | 5,421 | 0.4% |
| 59 | Clover | 5,399 | 2.0% |
| 60 | Walterboro | 5,311 | -0.5% |
| 61 | Central | 5,184 | 0.2% |
| 62 | Abbeville | 5,176 | -0.4% |
| 63 | Travelers Rest | 4,843 | 1.9% |
| 64 | Hollywood | 4,842 | 0.9% |
| 65 | Edgefield | 4,716 | -0.2% |
| 66 | Barnwell | 4,691 | -0.4% |
| 67 | Mullins | 4,573 | -0.6% |
| 68 | Isle of Palms | 4,294 | 1.3% |
| 69 | Hardeeville | 4,291 | 13.3% |
| 70 | Walhalla | 4,256 | -0.1% |
| 71 | Belton | 4,252 | 0.9% |
| 72 | Woodruff | 4,127 | 0.3% |
| 73 | Surfside Beach | 4,119 | 2.4% |
| 74 | Ridgeland | 4,111 | 0.6% |
| 75 | Manning | 4,088 | -0.2% |
| 76 | Williamston | 4,039 | 0.9% |
| 77 | Honea Path | 3,633 | 0.3% |
| 78 | Saluda | 3,600 | 0.3% |
| 79 | Bamberg | 3,512 | -0.9% |
| 80 | Denmark | 3,426 | -1.1% |
| 81 | Winnsboro | 3,422 | -1.2% |
| 82 | Lyman | 3,336 | 0.9% |
| 83 | Bishopville | 3,326 | -1.4% |
| 84 | Duncan | 3,269 | 0.9% |
| 85 | Allendale | 3,264 | -2.1% |
| 86 | Liberty | 3,257 | -0.1% |
| 87 | Kingstree | 3,231 | -1.0% |
| 88 | Pickens | 3,148 | 0.2% |
| 89 | Pendleton | 3,082 | 1.3% |
| 90 | Williston | 3,080 | -0.6% |
| 91 | Andrews | 2,847 | -0.2% |
| 92 | Burnettown | 2,746 | 0.9% |
| 93 | Pageland | 2,745 | -0.2% |
| 94 | McCormick | 2,740 | -0.5% |
| 95 | Hampton | 2,719 | -1.1% |
| 96 | Springdale | 2,712 | 1.0% |
| 97 | Folly Beach | 2,708 | 1.1% |
| 98 | Ravenel | 2,537 | 1.0% |
| 99 | Loris | 2,505 | 1.5% |
| 100 | Westminster | 2,464 | 0.6% |
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