| Rank | City | 2013 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 131,686 | 0.9% |
| 2 | Charleston | 125,583 | 2.3% |
| 3 | North Charleston | 101,989 | 2.3% |
| 4 | Mount Pleasant | 71,875 | 2.9% |
| 5 | Rock Hill | 68,094 | 1.5% |
| 6 | Greenville | 60,709 | 1.9% |
| 7 | Summerville | 44,719 | 1.5% |
| 8 | Sumter | 40,836 | 0.4% |
| 9 | Goose Creek | 38,579 | 3.6% |
| 10 | Hilton Head Island | 38,366 | 1.7% |
| 11 | Florence | 37,498 | 0.6% |
| 12 | Spartanburg | 37,401 | 0.5% |
| 13 | Aiken | 29,884 | 0.6% |
| 14 | Myrtle Beach | 28,292 | 2.2% |
| 15 | Anderson | 26,708 | 0.0% |
| 16 | Greer | 26,645 | 2.2% |
| 17 | Mauldin | 23,808 | 2.0% |
| 18 | Greenwood | 23,324 | 0.2% |
| 19 | North Augusta | 21,873 | 1.2% |
| 20 | Easley | 20,098 | 0.3% |
| 21 | Hanahan | 19,157 | 3.2% |
| 22 | Lexington | 19,141 | 3.5% |
| 23 | Simpsonville | 19,056 | 2.2% |
| 24 | Conway | 18,688 | 4.5% |
| 25 | West Columbia | 15,631 | 2.1% |
| 26 | North Myrtle Beach | 14,472 | 2.6% |
| 27 | Clemson | 14,089 | 0.7% |
| 28 | Orangeburg | 13,850 | -0.4% |
| 29 | Bluffton | 12,932 | 1.6% |
| 30 | Beaufort | 12,788 | 1.7% |
| 31 | Cayce | 12,679 | 0.6% |
| 32 | Gaffney | 12,449 | 0.1% |
| 33 | Irmo | 11,500 | 1.8% |
| 34 | Fort Mill | 11,387 | 2.6% |
| 35 | Port Royal | 11,265 | 2.7% |
| 36 | Forest Acres | 10,489 | 0.6% |
| 37 | Newberry | 10,255 | -0.1% |
| 38 | Georgetown | 9,092 | -0.4% |
| 39 | Laurens | 9,083 | -0.3% |
| 40 | Bennettsville | 8,873 | -1.1% |
| 41 | Lancaster | 8,755 | 1.3% |
| 42 | Moncks Corner | 8,662 | 4.8% |
| 43 | Clinton | 8,484 | -0.0% |
| 44 | Union | 8,183 | -1.3% |
| 45 | Seneca | 8,098 | -0.0% |
| 46 | Tega Cay | 7,934 | 2.0% |
| 47 | Fountain Inn | 7,898 | 0.6% |
| 48 | York | 7,883 | 0.9% |
| 49 | Hartsville | 7,850 | 0.6% |
| 50 | Camden | 6,906 | 0.5% |
| 51 | Marion | 6,839 | -0.7% |
| 52 | Lake City | 6,715 | 0.3% |
| 53 | Dillon | 6,669 | -0.9% |
| 54 | Darlington | 6,221 | -0.5% |
| 55 | Cheraw | 5,785 | -0.6% |
| 56 | Chester | 5,517 | -0.8% |
| 57 | Batesburg-Leesville | 5,397 | 0.3% |
| 58 | Walterboro | 5,309 | -0.8% |
| 59 | Clover | 5,287 | 1.9% |
| 60 | Abbeville | 5,179 | -0.6% |
| 61 | Central | 5,154 | -0.0% |
| 62 | Hollywood | 4,855 | 1.5% |
| 63 | Travelers Rest | 4,750 | 1.9% |
| 64 | Edgefield | 4,690 | -0.6% |
| 65 | Barnwell | 4,680 | -0.7% |
| 66 | Mullins | 4,594 | -0.7% |
| 67 | Walhalla | 4,248 | -0.2% |
| 68 | Isle of Palms | 4,247 | 1.4% |
| 69 | Belton | 4,206 | 0.9% |
| 70 | Woodruff | 4,114 | 0.3% |
| 71 | Ridgeland | 4,065 | 0.4% |
| 72 | Manning | 4,052 | -0.7% |
| 73 | Surfside Beach | 4,007 | 2.2% |
| 74 | Williamston | 3,992 | 0.7% |
| 75 | Hardeeville | 3,772 | 13.0% |
| 76 | Honea Path | 3,600 | 0.0% |
| 77 | Bamberg | 3,567 | -0.6% |
| 78 | Saluda | 3,564 | -0.0% |
| 79 | Denmark | 3,487 | -0.7% |
| 80 | Winnsboro | 3,454 | -1.4% |
| 81 | Bishopville | 3,367 | -1.5% |
| 82 | Allendale | 3,317 | -2.4% |
| 83 | Lyman | 3,301 | 0.9% |
| 84 | Kingstree | 3,260 | -1.0% |
| 85 | Liberty | 3,258 | -0.2% |
| 86 | Duncan | 3,236 | 0.9% |
| 87 | Pickens | 3,142 | 0.3% |
| 88 | Williston | 3,085 | -0.9% |
| 89 | Pendleton | 3,054 | 1.5% |
| 90 | Andrews | 2,831 | -0.5% |
| 91 | Hampton | 2,754 | -1.0% |
| 92 | McCormick | 2,735 | -0.9% |
| 93 | Pageland | 2,725 | -0.6% |
| 94 | Burnettown | 2,722 | 0.9% |
| 95 | Springdale | 2,684 | 0.9% |
| 96 | Folly Beach | 2,682 | 1.2% |
| 97 | Ravenel | 2,533 | 1.4% |
| 98 | Loris | 2,465 | 1.4% |
| 99 | Westminster | 2,430 | 0.2% |
| 100 | Landrum | 2,420 | 0.9% |
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