| Rank | City | 2012 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 130,799 | 1.2% |
| 2 | Charleston | 123,282 | 2.7% |
| 3 | North Charleston | 99,853 | 2.4% |
| 4 | Mount Pleasant | 69,395 | 2.3% |
| 5 | Rock Hill | 67,366 | 1.8% |
| 6 | Greenville | 59,880 | 2.5% |
| 7 | Summerville | 43,937 | 1.3% |
| 8 | Sumter | 40,530 | 0.0% |
| 9 | Hilton Head Island | 37,585 | 1.3% |
| 10 | Goose Creek | 37,429 | 4.1% |
| 11 | Florence | 37,318 | 0.7% |
| 12 | Spartanburg | 37,208 | 0.5% |
| 13 | Aiken | 29,835 | 1.1% |
| 14 | Myrtle Beach | 27,658 | 2.0% |
| 15 | Anderson | 26,579 | -0.4% |
| 16 | Greer | 26,118 | 2.4% |
| 17 | Greenwood | 23,314 | 0.4% |
| 18 | Mauldin | 23,258 | 1.6% |
| 19 | North Augusta | 21,709 | 1.7% |
| 20 | Easley | 20,091 | 0.5% |
| 21 | Simpsonville | 18,622 | 2.1% |
| 22 | Lexington | 18,614 | 4.2% |
| 23 | Hanahan | 18,389 | 2.2% |
| 24 | Conway | 17,815 | 4.2% |
| 25 | West Columbia | 15,450 | 3.1% |
| 26 | North Myrtle Beach | 14,159 | 3.0% |
| 27 | Clemson | 14,007 | 0.7% |
| 28 | Orangeburg | 13,868 | -0.7% |
| 29 | Bluffton | 12,680 | 1.2% |
| 30 | Cayce | 12,595 | 0.5% |
| 31 | Beaufort | 12,506 | 1.2% |
| 32 | Gaffney | 12,431 | 0.1% |
| 33 | Irmo | 11,314 | 2.0% |
| 34 | Fort Mill | 11,132 | 3.0% |
| 35 | Port Royal | 10,910 | 2.2% |
| 36 | Forest Acres | 10,436 | 0.7% |
| 37 | Newberry | 10,237 | -0.4% |
| 38 | Georgetown | 9,118 | -0.5% |
| 39 | Laurens | 9,097 | -0.5% |
| 40 | Bennettsville | 8,960 | -1.2% |
| 41 | Lancaster | 8,618 | 1.1% |
| 42 | Clinton | 8,506 | 0.2% |
| 43 | Moncks Corner | 8,306 | 5.3% |
| 44 | Union | 8,293 | -1.2% |
| 45 | Seneca | 8,068 | -0.4% |
| 46 | Hartsville | 7,859 | 1.2% |
| 47 | York | 7,829 | 1.2% |
| 48 | Fountain Inn | 7,811 | 0.2% |
| 49 | Tega Cay | 7,796 | 2.3% |
| 50 | Marion | 6,891 | -0.7% |
| 51 | Camden | 6,882 | 0.6% |
| 52 | Dillon | 6,720 | -1.0% |
| 53 | Lake City | 6,708 | 0.5% |
| 54 | Darlington | 6,234 | -0.9% |
| 55 | Cheraw | 5,841 | -0.2% |
| 56 | Chester | 5,560 | -0.8% |
| 57 | Batesburg-Leesville | 5,375 | 0.2% |
| 58 | Walterboro | 5,346 | -1.0% |
| 59 | Clover | 5,211 | 2.3% |
| 60 | Abbeville | 5,192 | -0.9% |
| 61 | Central | 5,162 | 0.1% |
| 62 | Hollywood | 4,805 | 1.9% |
| 63 | Edgefield | 4,723 | -0.6% |
| 64 | Barnwell | 4,715 | -0.7% |
| 65 | Travelers Rest | 4,660 | 1.8% |
| 66 | Mullins | 4,632 | -0.7% |
| 67 | Walhalla | 4,241 | -0.5% |
| 68 | Isle of Palms | 4,199 | 1.6% |
| 69 | Belton | 4,185 | 1.2% |
| 70 | Woodruff | 4,097 | 0.2% |
| 71 | Manning | 4,078 | -0.7% |
| 72 | Ridgeland | 4,050 | 0.3% |
| 73 | Williamston | 3,972 | 1.0% |
| 74 | Surfside Beach | 3,908 | 1.9% |
| 75 | Bamberg | 3,585 | -0.6% |
| 76 | Honea Path | 3,585 | -0.3% |
| 77 | Saluda | 3,550 | -0.4% |
| 78 | Denmark | 3,506 | -0.9% |
| 79 | Winnsboro | 3,492 | -1.6% |
| 80 | Bishopville | 3,413 | -1.7% |
| 81 | Allendale | 3,410 | -2.1% |
| 82 | Hardeeville | 3,380 | 14.5% |
| 83 | Kingstree | 3,306 | -0.7% |
| 84 | Liberty | 3,269 | – |
| 85 | Lyman | 3,269 | 0.8% |
| 86 | Duncan | 3,204 | 0.7% |
| 87 | Pickens | 3,134 | 0.3% |
| 88 | Williston | 3,110 | -0.9% |
| 89 | Pendleton | 3,039 | 2.5% |
| 90 | Andrews | 2,842 | -0.7% |
| 91 | Hampton | 2,759 | -1.7% |
| 92 | McCormick | 2,755 | -1.0% |
| 93 | Pageland | 2,753 | -0.3% |
| 94 | Burnettown | 2,708 | 1.3% |
| 95 | Springdale | 2,664 | 1.1% |
| 96 | Folly Beach | 2,655 | 1.5% |
| 97 | Ravenel | 2,498 | 1.3% |
| 98 | Loris | 2,430 | 1.4% |
| 99 | Westminster | 2,419 | 0.0% |
| 100 | Landrum | 2,397 | 0.9% |
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