| Rank | City | 2019 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Jackson | 164,422 | -0.7% |
| 2 | Gulfport | 71,870 | 0.7% |
| 3 | Southaven | 54,944 | 1.4% |
| 4 | Biloxi | 45,968 | 0.5% |
| 5 | Hattiesburg | 45,951 | -0.0% |
| 6 | Tupelo | 38,206 | 1.3% |
| 7 | Olive Branch | 38,149 | 1.6% |
| 8 | Meridian | 37,325 | -1.2% |
| 9 | Greenville | 29,898 | -1.7% |
| 10 | Horn Lake | 27,127 | 0.5% |
| 11 | Pearl | 26,471 | 0.7% |
| 12 | Madison | 25,676 | 0.8% |
| 13 | Starkville | 25,309 | 0.7% |
| 14 | Clinton | 25,179 | -0.0% |
| 15 | Oxford | 24,528 | 3.3% |
| 16 | Ridgeland | 24,188 | 0.1% |
| 17 | Brandon | 24,156 | 1.3% |
| 18 | Columbus | 23,853 | 0.1% |
| 19 | Vicksburg | 22,136 | -0.9% |
| 20 | Pascagoula | 21,685 | -0.4% |
| 21 | Gautier | 18,566 | -0.0% |
| 22 | Laurel | 18,478 | -0.0% |
| 23 | Ocean Springs | 17,809 | 0.3% |
| 24 | Hernando | 16,317 | 1.9% |
| 25 | Long Beach | 15,824 | 0.8% |
| 26 | Clarksdale | 15,304 | -2.0% |
| 27 | Natchez | 15,009 | -0.6% |
| 28 | Corinth | 14,485 | -0.1% |
| 29 | D'Iberville | 13,831 | 4.8% |
| 30 | Greenwood | 13,790 | -1.2% |
| 31 | Bay St. Louis | 13,515 | 4.8% |
| 32 | Moss Point | 13,378 | -0.3% |
| 33 | McComb | 13,045 | 0.2% |
| 34 | Grenada | 12,466 | -0.6% |
| 35 | Canton | 12,232 | -0.9% |
| 36 | Brookhaven | 12,089 | -0.4% |
| 37 | Byram | 11,655 | 0.2% |
| 38 | Cleveland | 11,501 | -0.9% |
| 39 | Picayune | 11,008 | 0.1% |
| 40 | Yazoo City | 10,825 | -0.6% |
| 41 | Petal | 10,674 | 0.3% |
| 42 | West Point | 10,520 | -0.9% |
| 43 | Indianola | 9,252 | -1.8% |
| 44 | Flowood | 9,219 | 2.1% |
| 45 | New Albany | 8,761 | 1.1% |
| 46 | Booneville | 8,740 | -0.0% |
| 47 | Diamondhead | 8,044 | – |
| 48 | Senatobia | 8,010 | -0.2% |
| 49 | Holly Springs | 7,652 | -0.1% |
| 50 | Batesville | 7,257 | -0.3% |
| 51 | Richland | 7,187 | 0.5% |
| 52 | Philadelphia | 7,172 | -0.5% |
| 53 | Amory | 6,871 | -0.8% |
| 54 | Kosciusko | 6,837 | -1.0% |
| 55 | Waveland | 6,322 | -0.2% |
| 56 | Louisville | 6,227 | -0.8% |
| 57 | Pontotoc | 6,144 | 1.1% |
| 58 | Pass Christian | 6,075 | 3.5% |
| 59 | Columbia | 5,941 | -1.3% |
| 60 | Forest | 5,608 | -0.2% |
| 61 | Aberdeen | 5,265 | -0.8% |
| 62 | Ripley | 5,264 | -0.3% |
| 63 | Saltillo | 5,019 | 0.7% |
| 64 | Ellisville | 4,914 | 1.3% |
| 65 | Waynesboro | 4,872 | -0.4% |
| 66 | Crystal Springs | 4,838 | -0.5% |
| 67 | Carthage | 4,816 | -0.7% |
| 68 | Wiggins | 4,595 | 0.6% |
| 69 | Florence | 4,460 | 0.9% |
| 70 | Magee | 4,210 | -0.6% |
| 71 | Winona | 4,146 | -2.4% |
| 72 | Fulton | 4,033 | 0.2% |
| 73 | Leland | 3,863 | -1.8% |
| 74 | Hazlehurst | 3,838 | -0.5% |
| 75 | Morton | 3,630 | 0.6% |
| 76 | Houston | 3,459 | -0.6% |
| 77 | Tutwiler | 3,433 | -0.4% |
| 78 | Water Valley | 3,339 | -0.2% |
| 79 | Baldwyn | 3,293 | -0.0% |
| 80 | Verona | 3,235 | 0.9% |
| 81 | Newton | 3,223 | -0.6% |
| 82 | Lucedale | 3,134 | 0.9% |
| 83 | Iuka | 2,955 | -0.3% |
| 84 | Poplarville | 2,938 | 0.2% |
| 85 | Guntown | 2,770 | 3.6% |
| 86 | Ruleville | 2,619 | -1.7% |
| 87 | Okolona | 2,548 | -0.7% |
| 88 | Raymond | 2,505 | 3.3% |
| 89 | Macon | 2,485 | -1.3% |
| 90 | Collins | 2,451 | -0.7% |
| 91 | Mendenhall | 2,414 | -0.5% |
| 92 | Hollandale | 2,374 | -1.6% |
| 93 | Purvis | 2,351 | 1.0% |
| 94 | Durant | 2,331 | -1.7% |
| 95 | Magnolia | 2,257 | -0.9% |
| 96 | Lumberton | 2,199 | 0.7% |
| 97 | Farmington | 2,164 | -0.1% |
| 98 | Quitman | 2,111 | -1.2% |
| 99 | Moorhead | 2,078 | -1.8% |
| 100 | Eupora | 2,038 | -0.9% |
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