| Rank | City | 2010 Population | Growth Rate (Annual) | 
|---|---|---|---|
| 1 | Jackson | 173,514 | -0.7% | 
| 2 | Gulfport | 67,793 | -0.5% | 
| 3 | Southaven | 48,982 | 5.2% | 
| 4 | Hattiesburg | 45,989 | -0.0% | 
| 5 | Biloxi | 44,054 | -1.4% | 
| 6 | Meridian | 41,148 | -0.0% | 
| 7 | Tupelo | 34,546 | 0.1% | 
| 8 | Greenville | 34,400 | -1.8% | 
| 9 | Olive Branch | 33,484 | 4.6% | 
| 10 | Horn Lake | 26,066 | 2.6% | 
| 11 | Clinton | 25,216 | 0.0% | 
| 12 | Pearl | 25,092 | 1.0% | 
| 13 | Madison | 24,149 | 2.4% | 
| 14 | Ridgeland | 24,047 | 1.7% | 
| 15 | Starkville | 23,888 | 0.8% | 
| 16 | Vicksburg | 23,856 | -1.0% | 
| 17 | Columbus | 23,640 | -0.9% | 
| 18 | Pascagoula | 22,392 | -1.5% | 
| 19 | Brandon | 21,705 | 2.1% | 
| 20 | Oxford | 18,916 | 3.3% | 
| 21 | Gautier | 18,572 | 1.0% | 
| 22 | Laurel | 18,540 | 0.1% | 
| 23 | Clarksdale | 17,962 | -1.4% | 
| 24 | Ocean Springs | 17,442 | 0.1% | 
| 25 | Natchez | 15,792 | -1.5% | 
| 26 | Greenwood | 15,205 | -1.9% | 
| 27 | Long Beach | 14,792 | -1.5% | 
| 28 | Corinth | 14,573 | 0.4% | 
| 29 | Hernando | 14,090 | 5.7% | 
| 30 | Moss Point | 13,704 | -1.4% | 
| 31 | Canton | 13,189 | 0.2% | 
| 32 | Grenada | 13,092 | -1.2% | 
| 33 | McComb | 12,790 | -0.4% | 
| 34 | Brookhaven | 12,513 | -0.4% | 
| 35 | Cleveland | 12,334 | -1.1% | 
| 36 | Byram | 11,489 | – | 
| 37 | Yazoo City | 11,403 | -0.6% | 
| 38 | West Point | 11,307 | -0.7% | 
| 39 | Picayune | 10,878 | 0.3% | 
| 40 | Indianola | 10,683 | -1.2% | 
| 41 | Petal | 10,454 | 0.6% | 
| 42 | D'Iberville | 9,486 | 1.8% | 
| 43 | Bay St. Louis | 9,260 | -2.1% | 
| 44 | Booneville | 8,743 | 0.1% | 
| 45 | Senatobia | 8,165 | 1.5% | 
| 46 | New Albany | 8,034 | 0.4% | 
| 47 | Flowood | 7,823 | 3.5% | 
| 48 | Holly Springs | 7,699 | -0.3% | 
| 49 | Philadelphia | 7,477 | 0.1% | 
| 50 | Batesville | 7,463 | -0.0% | 
| 51 | Kosciusko | 7,402 | 0.0% | 
| 52 | Amory | 7,316 | -0.4% | 
| 53 | Richland | 6,912 | 1.0% | 
| 54 | Louisville | 6,631 | -0.5% | 
| 55 | Columbia | 6,582 | -0.0% | 
| 56 | Waveland | 6,435 | -2.1% | 
| 57 | Forest | 5,684 | -0.5% | 
| 58 | Pontotoc | 5,625 | 0.4% | 
| 59 | Aberdeen | 5,612 | -1.3% | 
| 60 | Ripley | 5,395 | -0.2% | 
| 61 | Carthage | 5,075 | 0.9% | 
| 62 | Crystal Springs | 5,044 | -1.5% | 
| 63 | Waynesboro | 5,043 | -1.3% | 
| 64 | Winona | 5,043 | -0.7% | 
| 65 | Saltillo | 4,752 | 3.4% | 
| 66 | Pass Christian | 4,613 | -3.5% | 
| 67 | Leland | 4,481 | -2.0% | 
| 68 | Ellisville | 4,448 | 0.7% | 
| 69 | Magee | 4,408 | 0.5% | 
| 70 | Wiggins | 4,390 | 1.3% | 
| 71 | Florence | 4,141 | 5.0% | 
| 72 | Hazlehurst | 4,009 | -0.9% | 
| 73 | Fulton | 3,961 | 0.2% | 
| 74 | Houston | 3,623 | -1.1% | 
| 75 | Tutwiler | 3,550 | 10.1% | 
| 76 | Morton | 3,462 | -0.1% | 
| 77 | Water Valley | 3,392 | -0.9% | 
| 78 | Newton | 3,373 | -0.9% | 
| 79 | Baldwyn | 3,297 | -0.1% | 
| 80 | Iuka | 3,028 | -0.1% | 
| 81 | Ruleville | 3,007 | -0.7% | 
| 82 | Verona | 3,006 | -1.0% | 
| 83 | Lucedale | 2,923 | 1.6% | 
| 84 | Poplarville | 2,894 | 1.1% | 
| 85 | Macon | 2,768 | -0.8% | 
| 86 | Hollandale | 2,702 | -2.3% | 
| 87 | Okolona | 2,692 | -1.3% | 
| 88 | Durant | 2,673 | -0.9% | 
| 89 | Collins | 2,586 | -0.4% | 
| 90 | Mendenhall | 2,504 | -0.2% | 
| 91 | Magnolia | 2,420 | 1.5% | 
| 92 | Moorhead | 2,405 | -0.6% | 
| 93 | Quitman | 2,323 | -0.6% | 
| 94 | Belzoni | 2,235 | -1.7% | 
| 95 | Shelby | 2,229 | -2.6% | 
| 96 | Eupora | 2,197 | -0.6% | 
| 97 | Charleston | 2,193 | – | 
| 98 | Farmington | 2,186 | 0.2% | 
| 99 | Purvis | 2,175 | -0.0% | 
| 100 | Rolling Fork | 2,143 | -1.4% | 
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