| Rank | City | 2018 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Jackson | 166,965 | -0.5% |
| 2 | Gulfport | 71,822 | 0.8% |
| 3 | Southaven | 54,031 | 1.4% |
| 4 | Hattiesburg | 46,377 | 0.1% |
| 5 | Biloxi | 45,908 | 0.6% |
| 6 | Tupelo | 38,114 | 1.4% |
| 7 | Meridian | 37,940 | -1.2% |
| 8 | Olive Branch | 37,435 | 1.6% |
| 9 | Greenville | 30,686 | -1.6% |
| 10 | Horn Lake | 27,095 | 0.6% |
| 11 | Pearl | 26,534 | 0.8% |
| 12 | Madison | 25,627 | 0.9% |
| 13 | Starkville | 25,352 | 0.9% |
| 14 | Clinton | 25,154 | -0.0% |
| 15 | Ridgeland | 24,266 | 0.1% |
| 16 | Columbus | 24,041 | 0.2% |
| 17 | Brandon | 23,999 | 1.4% |
| 18 | Oxford | 23,639 | 3.2% |
| 19 | Vicksburg | 22,489 | -0.8% |
| 20 | Pascagoula | 21,733 | -0.4% |
| 21 | Gautier | 18,512 | -0.0% |
| 22 | Laurel | 18,493 | -0.0% |
| 23 | Ocean Springs | 17,682 | 0.2% |
| 24 | Hernando | 15,981 | 1.8% |
| 25 | Clarksdale | 15,732 | -1.9% |
| 26 | Long Beach | 15,642 | 0.8% |
| 27 | Natchez | 14,886 | -0.8% |
| 28 | Corinth | 14,643 | 0.1% |
| 29 | Greenwood | 13,996 | -1.2% |
| 30 | Moss Point | 13,398 | -0.3% |
| 31 | Bay St. Louis | 13,043 | 5.0% |
| 32 | McComb | 12,799 | 0.0% |
| 33 | Canton | 12,725 | -0.5% |
| 34 | Grenada | 12,511 | -0.6% |
| 35 | Brookhaven | 12,173 | -0.4% |
| 36 | Cleveland | 11,729 | -0.7% |
| 37 | Byram | 11,671 | 0.2% |
| 38 | D'Iberville | 11,610 | 2.9% |
| 39 | Yazoo City | 10,987 | -0.5% |
| 40 | West Point | 10,675 | -0.8% |
| 41 | Petal | 10,633 | 0.2% |
| 42 | Picayune | 10,382 | -0.7% |
| 43 | Indianola | 9,433 | -1.8% |
| 44 | Flowood | 9,061 | 2.1% |
| 45 | New Albany | 8,757 | 1.2% |
| 46 | Booneville | 8,693 | -0.1% |
| 47 | Diamondhead | 8,071 | – |
| 48 | Senatobia | 7,869 | -0.5% |
| 49 | Holly Springs | 7,621 | -0.1% |
| 50 | Philadelphia | 7,271 | -0.4% |
| 51 | Batesville | 7,241 | -0.4% |
| 52 | Richland | 7,220 | 0.6% |
| 53 | Amory | 6,958 | -0.7% |
| 54 | Kosciusko | 6,891 | -1.0% |
| 55 | Waveland | 6,354 | -0.2% |
| 56 | Louisville | 6,279 | -0.8% |
| 57 | Pontotoc | 6,077 | 1.1% |
| 58 | Columbia | 6,037 | -1.2% |
| 59 | Pass Christian | 5,878 | 3.5% |
| 60 | Forest | 5,655 | -0.1% |
| 61 | Aberdeen | 5,328 | -0.7% |
| 62 | Ripley | 5,278 | -0.3% |
| 63 | Saltillo | 4,987 | 0.7% |
| 64 | Waynesboro | 4,903 | -0.4% |
| 65 | Crystal Springs | 4,853 | -0.5% |
| 66 | Carthage | 4,822 | -0.7% |
| 67 | Ellisville | 4,549 | 0.3% |
| 68 | Wiggins | 4,543 | 0.5% |
| 69 | Florence | 4,427 | 1.0% |
| 70 | Winona | 4,280 | -2.3% |
| 71 | Magee | 4,274 | -0.4% |
| 72 | Fulton | 4,011 | 0.2% |
| 73 | Leland | 3,981 | -1.7% |
| 74 | Hazlehurst | 3,852 | -0.6% |
| 75 | Houston | 3,464 | -0.6% |
| 76 | Morton | 3,423 | -0.2% |
| 77 | Water Valley | 3,362 | -0.1% |
| 78 | Baldwyn | 3,304 | 0.0% |
| 79 | Verona | 3,246 | 1.1% |
| 80 | Newton | 3,219 | -0.7% |
| 81 | Lucedale | 3,062 | 0.7% |
| 82 | Iuka | 2,964 | -0.3% |
| 83 | Poplarville | 2,929 | 0.2% |
| 84 | Guntown | 2,735 | 4.0% |
| 85 | Ruleville | 2,671 | -1.7% |
| 86 | Okolona | 2,560 | -0.7% |
| 87 | Macon | 2,537 | -1.2% |
| 88 | Collins | 2,481 | -0.6% |
| 89 | Hollandale | 2,443 | -1.4% |
| 90 | Mendenhall | 2,433 | -0.4% |
| 91 | Durant | 2,365 | -1.7% |
| 92 | Purvis | 2,322 | 0.9% |
| 93 | Magnolia | 2,283 | -0.8% |
| 94 | Lumberton | 2,211 | 0.8% |
| 95 | Raymond | 2,210 | 1.9% |
| 96 | Farmington | 2,181 | -0.0% |
| 97 | Moorhead | 2,176 | -1.4% |
| 98 | Quitman | 2,151 | -1.1% |
| 99 | Eupora | 2,051 | -1.0% |
| 100 | Shelby | 2,035 | -1.3% |
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