| Rank | City | 2017 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Jackson | 169,148 | -0.4% |
| 2 | Gulfport | 72,076 | 1.0% |
| 3 | Southaven | 53,214 | 1.4% |
| 4 | Hattiesburg | 46,926 | 0.3% |
| 5 | Biloxi | 45,975 | 0.7% |
| 6 | Meridian | 39,113 | -0.8% |
| 7 | Tupelo | 38,842 | 2.0% |
| 8 | Olive Branch | 36,699 | 1.5% |
| 9 | Greenville | 31,517 | -1.4% |
| 10 | Horn Lake | 27,042 | 0.6% |
| 11 | Pearl | 26,485 | 0.9% |
| 12 | Madison | 26,031 | 1.3% |
| 13 | Starkville | 25,570 | 1.1% |
| 14 | Clinton | 25,211 | -0.0% |
| 15 | Columbus | 24,561 | 0.6% |
| 16 | Ridgeland | 24,483 | 0.3% |
| 17 | Brandon | 23,826 | 1.6% |
| 18 | Oxford | 23,290 | 3.5% |
| 19 | Vicksburg | 22,925 | -0.7% |
| 20 | Pascagoula | 21,981 | -0.3% |
| 21 | Laurel | 18,756 | 0.2% |
| 22 | Gautier | 18,471 | -0.1% |
| 23 | Ocean Springs | 17,652 | 0.2% |
| 24 | Clarksdale | 16,272 | -1.6% |
| 25 | Long Beach | 15,677 | 1.0% |
| 26 | Hernando | 15,631 | 1.7% |
| 27 | Natchez | 15,109 | -0.7% |
| 28 | Corinth | 14,818 | 0.3% |
| 29 | Greenwood | 14,415 | -0.9% |
| 30 | Canton | 13,643 | 0.6% |
| 31 | Moss Point | 13,570 | -0.2% |
| 32 | McComb | 12,811 | 0.0% |
| 33 | Grenada | 12,708 | -0.5% |
| 34 | Bay St. Louis | 12,667 | 5.4% |
| 35 | Brookhaven | 12,359 | -0.2% |
| 36 | Cleveland | 12,101 | -0.3% |
| 37 | Byram | 11,545 | 0.1% |
| 38 | D'Iberville | 11,503 | 3.3% |
| 39 | Yazoo City | 11,180 | -0.3% |
| 40 | West Point | 10,880 | -0.6% |
| 41 | Petal | 10,704 | 0.4% |
| 42 | Picayune | 10,625 | -0.4% |
| 43 | Indianola | 9,655 | -1.7% |
| 44 | Flowood | 8,859 | 2.1% |
| 45 | New Albany | 8,786 | 1.5% |
| 46 | Booneville | 8,744 | 0.0% |
| 47 | Diamondhead | 8,217 | – |
| 48 | Senatobia | 7,909 | -0.5% |
| 49 | Holly Springs | 7,682 | -0.0% |
| 50 | Batesville | 7,391 | -0.2% |
| 51 | Philadelphia | 7,361 | -0.3% |
| 52 | Kosciusko | 7,139 | -0.6% |
| 53 | Richland | 7,111 | 0.5% |
| 54 | Amory | 7,067 | -0.6% |
| 55 | Waveland | 6,428 | -0.0% |
| 56 | Louisville | 6,324 | -0.8% |
| 57 | Columbia | 6,143 | -1.1% |
| 58 | Pontotoc | 6,109 | 1.4% |
| 59 | Pass Christian | 5,701 | 3.6% |
| 60 | Forest | 5,672 | -0.0% |
| 61 | Aberdeen | 5,391 | -0.7% |
| 62 | Ripley | 5,373 | -0.1% |
| 63 | Saltillo | 5,008 | 0.9% |
| 64 | Waynesboro | 4,944 | -0.3% |
| 65 | Crystal Springs | 4,889 | -0.5% |
| 66 | Carthage | 4,860 | -0.7% |
| 67 | Ellisville | 4,567 | 0.4% |
| 68 | Wiggins | 4,545 | 0.6% |
| 69 | Florence | 4,396 | 1.0% |
| 70 | Winona | 4,383 | -2.3% |
| 71 | Magee | 4,315 | -0.4% |
| 72 | Leland | 4,104 | -1.5% |
| 73 | Fulton | 4,066 | 0.4% |
| 74 | Hazlehurst | 3,883 | -0.5% |
| 75 | Houston | 3,524 | -0.5% |
| 76 | Morton | 3,434 | -0.1% |
| 77 | Water Valley | 3,393 | 0.0% |
| 78 | Baldwyn | 3,332 | 0.2% |
| 79 | Newton | 3,317 | -0.3% |
| 80 | Lucedale | 3,043 | 0.7% |
| 81 | Verona | 3,019 | 0.1% |
| 82 | Iuka | 2,989 | -0.2% |
| 83 | Poplarville | 2,977 | 0.5% |
| 84 | Ruleville | 2,727 | -1.6% |
| 85 | Guntown | 2,720 | 4.5% |
| 86 | Okolona | 2,618 | -0.5% |
| 87 | Macon | 2,614 | -0.9% |
| 88 | Collins | 2,569 | -0.1% |
| 89 | Hollandale | 2,496 | -1.3% |
| 90 | Mendenhall | 2,457 | -0.3% |
| 91 | Durant | 2,431 | -1.6% |
| 92 | Purvis | 2,341 | 1.2% |
| 93 | Magnolia | 2,330 | -0.6% |
| 94 | Lumberton | 2,226 | 1.1% |
| 95 | Raymond | 2,220 | 2.3% |
| 96 | Moorhead | 2,215 | -1.4% |
| 97 | Quitman | 2,189 | -1.0% |
| 98 | Farmington | 2,189 | 0.0% |
| 99 | Shelby | 2,083 | -1.1% |
| 100 | Eupora | 2,075 | -0.9% |
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