| Rank | City | 2010 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Jackson | 175,021 | -0.6% |
| 2 | Gulfport | 70,794 | -0.1% |
| 3 | Hattiesburg | 53,582 | 1.7% |
| 4 | Biloxi | 45,766 | -1.1% |
| 5 | Southaven | 45,395 | 4.9% |
| 6 | Meridian | 39,695 | -0.4% |
| 7 | Tupelo | 36,337 | 0.6% |
| 8 | Greenville | 35,355 | -1.7% |
| 9 | Olive Branch | 32,531 | 4.8% |
| 10 | Clinton | 26,258 | 0.5% |
| 11 | Horn Lake | 25,113 | 2.5% |
| 12 | Vicksburg | 24,896 | -0.6% |
| 13 | Pearl | 24,840 | 1.0% |
| 14 | Starkville | 24,324 | 1.1% |
| 15 | Columbus | 23,818 | -0.9% |
| 16 | Pascagoula | 23,692 | -1.1% |
| 17 | Brandon | 22,335 | 2.6% |
| 18 | Madison | 21,938 | 1.6% |
| 19 | Ridgeland | 21,690 | 0.7% |
| 20 | Laurel | 18,855 | 0.4% |
| 21 | Clarksdale | 17,734 | -1.6% |
| 22 | Oxford | 17,636 | 2.9% |
| 23 | Ocean Springs | 17,363 | 0.1% |
| 24 | Gautier | 16,460 | -0.3% |
| 25 | Natchez | 16,045 | -1.5% |
| 26 | Greenwood | 15,808 | -1.7% |
| 27 | Grenada | 14,656 | -0.1% |
| 28 | Corinth | 14,289 | 0.2% |
| 29 | Moss Point | 13,952 | -1.4% |
| 30 | McComb | 13,645 | 0.3% |
| 31 | Brookhaven | 13,206 | 0.2% |
| 32 | Hernando | 12,771 | 5.2% |
| 33 | Canton | 12,572 | -0.3% |
| 34 | Long Beach | 12,245 | -3.7% |
| 35 | Cleveland | 12,027 | -1.5% |
| 36 | Picayune | 12,023 | 1.5% |
| 37 | West Point | 11,166 | -0.9% |
| 38 | Yazoo City | 11,144 | -1.0% |
| 39 | Petal | 10,799 | 1.0% |
| 40 | Indianola | 10,503 | -1.5% |
| 41 | D'Iberville | 8,954 | 1.4% |
| 42 | Booneville | 8,766 | 0.2% |
| 43 | Bay St. Louis | 8,407 | -3.3% |
| 44 | New Albany | 8,153 | 0.6% |
| 45 | Philadelphia | 7,903 | 0.8% |
| 46 | Holly Springs | 7,871 | -0.1% |
| 47 | Batesville | 7,743 | 0.4% |
| 48 | Senatobia | 7,421 | 0.6% |
| 49 | Richland | 7,380 | 1.9% |
| 50 | Kosciusko | 7,348 | -0.0% |
| 51 | Amory | 7,160 | -0.6% |
| 52 | Flowood | 7,062 | 2.7% |
| 53 | Louisville | 6,591 | -0.7% |
| 54 | Columbia | 6,520 | -0.2% |
| 55 | Forest | 6,033 | 0.1% |
| 56 | Aberdeen | 6,001 | -0.7% |
| 57 | Pontotoc | 5,943 | 1.1% |
| 58 | Crystal Springs | 5,892 | 0.1% |
| 59 | Ripley | 5,743 | 0.5% |
| 60 | Waveland | 5,690 | -3.7% |
| 61 | Waynesboro | 5,618 | -0.3% |
| 62 | Wiggins | 5,024 | 3.0% |
| 63 | Carthage | 4,875 | 0.6% |
| 64 | Leland | 4,743 | -1.6% |
| 65 | Ellisville | 4,469 | 0.8% |
| 66 | Winona | 4,435 | -2.2% |
| 67 | Saltillo | 4,328 | 2.7% |
| 68 | Hazlehurst | 4,328 | -0.2% |
| 69 | Magee | 4,315 | 0.3% |
| 70 | Pass Christian | 4,073 | -5.2% |
| 71 | Fulton | 4,032 | 0.4% |
| 72 | Water Valley | 3,976 | 0.8% |
| 73 | Houston | 3,828 | -0.7% |
| 74 | Florence | 3,722 | 4.3% |
| 75 | Newton | 3,688 | -0.0% |
| 76 | Morton | 3,480 | -0.0% |
| 77 | Verona | 3,416 | 0.3% |
| 78 | Baldwyn | 3,332 | 0.0% |
| 79 | Lucedale | 3,084 | 2.4% |
| 80 | Poplarville | 2,998 | 1.6% |
| 81 | Hollandale | 2,949 | -1.6% |
| 82 | Iuka | 2,935 | -0.4% |
| 83 | Collins | 2,861 | 0.7% |
| 84 | Okolona | 2,833 | -0.8% |
| 85 | Ruleville | 2,770 | -1.7% |
| 86 | Lumberton | 2,748 | 2.3% |
| 87 | Purvis | 2,697 | 2.4% |
| 88 | Macon | 2,679 | -1.2% |
| 89 | Durant | 2,649 | -1.1% |
| 90 | Shelby | 2,574 | -1.4% |
| 91 | Mendenhall | 2,537 | -0.1% |
| 92 | Belzoni | 2,342 | -1.4% |
| 93 | Rosedale | 2,286 | -0.6% |
| 94 | Quitman | 2,285 | -0.8% |
| 95 | Moorhead | 2,261 | -1.4% |
| 96 | Farmington | 2,221 | 0.4% |
| 97 | Eupora | 2,186 | -0.7% |
| 98 | Tchula | 2,173 | -0.9% |
| 99 | Bay Springs | 2,162 | 0.3% |
| 100 | Union | 2,147 | 0.7% |
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