| Rank | City | 2005 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Jackson | 180,383 | -0.7% |
| 2 | Gulfport | 72,691 | 0.4% |
| 3 | Biloxi | 50,817 | 0.1% |
| 4 | Hattiesburg | 47,768 | 0.9% |
| 5 | Meridian | 40,057 | -0.8% |
| 6 | Greenville | 38,063 | -2.1% |
| 7 | Southaven | 36,082 | 5.2% |
| 8 | Tupelo | 35,162 | 0.6% |
| 9 | Olive Branch | 26,409 | 5.5% |
| 10 | Clinton | 25,949 | 0.8% |
| 11 | Vicksburg | 25,624 | -0.7% |
| 12 | Pascagoula | 25,591 | -0.6% |
| 13 | Columbus | 24,572 | -1.3% |
| 14 | Pearl | 23,654 | 1.0% |
| 15 | Starkville | 22,510 | 0.6% |
| 16 | Horn Lake | 21,741 | 1.9% |
| 17 | Ridgeland | 21,684 | 1.6% |
| 18 | Madison | 20,557 | 2.0% |
| 19 | Brandon | 19,693 | 2.7% |
| 20 | Clarksdale | 19,202 | -1.7% |
| 21 | Laurel | 18,027 | -0.3% |
| 22 | Ocean Springs | 17,530 | 0.4% |
| 23 | Long Beach | 17,447 | 0.3% |
| 24 | Greenwood | 17,368 | -1.5% |
| 25 | Natchez | 16,952 | -2.0% |
| 26 | Gautier | 16,767 | -0.1% |
| 27 | Oxford | 15,299 | 2.8% |
| 28 | Moss Point | 15,165 | -1.1% |
| 29 | Grenada | 14,441 | -0.7% |
| 30 | Corinth | 14,085 | 0.0% |
| 31 | McComb | 12,938 | -0.7% |
| 32 | Brookhaven | 12,861 | -0.2% |
| 33 | Canton | 12,830 | -0.2% |
| 34 | Cleveland | 12,708 | -2.0% |
| 35 | Yazoo City | 11,703 | -1.0% |
| 36 | West Point | 11,653 | -1.0% |
| 37 | Bay St. Louis | 11,269 | -0.3% |
| 38 | Indianola | 11,207 | -1.7% |
| 39 | Picayune | 10,631 | 0.2% |
| 40 | Hernando | 10,135 | 5.8% |
| 41 | Petal | 10,036 | 0.4% |
| 42 | Booneville | 8,622 | -0.0% |
| 43 | Waveland | 8,269 | 0.9% |
| 44 | D'Iberville | 8,118 | 0.7% |
| 45 | Holly Springs | 7,987 | 0.1% |
| 46 | New Albany | 7,815 | 0.4% |
| 47 | Batesville | 7,546 | 0.3% |
| 48 | Philadelphia | 7,451 | 0.2% |
| 49 | Amory | 7,351 | -0.8% |
| 50 | Kosciusko | 7,227 | -0.5% |
| 51 | Senatobia | 7,128 | 0.4% |
| 52 | Richland | 7,048 | 3.1% |
| 53 | Pass Christian | 6,882 | 1.1% |
| 54 | Louisville | 6,767 | -0.8% |
| 55 | Columbia | 6,395 | -0.8% |
| 56 | Flowood | 6,329 | 3.3% |
| 57 | Aberdeen | 6,198 | -0.8% |
| 58 | Forest | 6,003 | 0.1% |
| 59 | Crystal Springs | 5,874 | 0.0% |
| 60 | Pontotoc | 5,742 | 1.6% |
| 61 | Waynesboro | 5,634 | -0.6% |
| 62 | Ripley | 5,546 | 0.3% |
| 63 | Leland | 5,069 | -1.9% |
| 64 | Winona | 4,901 | -2.5% |
| 65 | Carthage | 4,706 | 0.4% |
| 66 | Hazlehurst | 4,342 | -0.3% |
| 67 | Wiggins | 4,269 | 2.5% |
| 68 | Ellisville | 4,242 | 0.5% |
| 69 | Magee | 4,206 | 0.1% |
| 70 | Fulton | 4,013 | 0.7% |
| 71 | Houston | 3,980 | -0.5% |
| 72 | Water Valley | 3,779 | 0.5% |
| 73 | Newton | 3,623 | -0.5% |
| 74 | Saltillo | 3,583 | 1.4% |
| 75 | Morton | 3,440 | -0.3% |
| 76 | Verona | 3,356 | 0.1% |
| 77 | Baldwyn | 3,327 | 0.0% |
| 78 | Hollandale | 3,131 | -2.2% |
| 79 | Florence | 2,974 | 4.0% |
| 80 | Okolona | 2,957 | -0.8% |
| 81 | Ruleville | 2,943 | -2.2% |
| 82 | Iuka | 2,943 | -0.9% |
| 83 | Macon | 2,839 | -1.3% |
| 84 | Lucedale | 2,833 | 3.3% |
| 85 | Durant | 2,801 | -1.1% |
| 86 | Collins | 2,738 | 0.5% |
| 87 | Shelby | 2,680 | -2.0% |
| 88 | Poplarville | 2,665 | 0.6% |
| 89 | Mendenhall | 2,513 | -0.4% |
| 90 | Belzoni | 2,506 | -1.5% |
| 91 | Lumberton | 2,399 | 1.6% |
| 92 | Moorhead | 2,385 | -1.8% |
| 93 | Rosedale | 2,383 | -0.4% |
| 94 | Purvis | 2,371 | 2.1% |
| 95 | Quitman | 2,362 | -1.0% |
| 96 | Rolling Fork | 2,260 | -2.2% |
| 97 | Tchula | 2,233 | -1.3% |
| 98 | Eupora | 2,217 | -1.2% |
| 99 | Drew | 2,213 | -2.2% |
| 100 | Shaw | 2,202 | -1.2% |
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