| Rank | City | 2019 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 491,918 | 0.8% |
| 2 | St. Louis | 302,838 | -0.7% |
| 3 | Springfield | 168,122 | 0.7% |
| 4 | Columbia | 123,180 | 1.6% |
| 5 | Independence | 116,925 | 0.0% |
| 6 | Lee's Summit | 98,461 | 0.9% |
| 7 | O'Fallon | 88,472 | 1.4% |
| 8 | St. Joseph | 75,959 | -0.1% |
| 9 | St. Charles | 70,764 | 0.9% |
| 10 | St. Peters | 57,127 | 1.0% |
| 11 | Blue Springs | 55,104 | 0.6% |
| 12 | Florissant | 51,272 | -0.2% |
| 13 | Joplin | 50,657 | 0.1% |
| 14 | Chesterfield | 47,644 | 0.0% |
| 15 | Jefferson City | 42,838 | -0.1% |
| 16 | Wentzville | 41,164 | 4.4% |
| 17 | Cape Girardeau | 39,853 | 0.6% |
| 18 | Wildwood | 35,517 | – |
| 19 | University City | 34,322 | -0.4% |
| 20 | Liberty | 31,779 | 1.1% |
| 21 | Ballwin | 30,188 | -0.1% |
| 22 | Raytown | 28,993 | -0.2% |
| 23 | Kirkwood | 27,758 | 0.1% |
| 24 | Gladstone | 27,317 | 0.9% |
| 25 | Maryland Heights | 27,016 | -0.2% |
| 26 | Hazelwood | 25,204 | -0.2% |
| 27 | Grandview | 24,962 | 0.2% |
| 28 | Belton | 23,598 | 0.3% |
| 29 | Webster Groves | 22,889 | -0.1% |
| 30 | Nixa | 21,868 | 1.8% |
| 31 | Raymore | 21,784 | 1.6% |
| 32 | Sedalia | 21,718 | 0.2% |
| 33 | Arnold | 21,073 | 0.2% |
| 34 | Ferguson | 20,730 | -0.3% |
| 35 | Rolla | 20,390 | 0.5% |
| 36 | Warrensburg | 20,262 | 0.9% |
| 37 | Ozark | 20,188 | 1.6% |
| 38 | Farmington | 18,843 | 1.9% |
| 39 | Creve Coeur | 18,717 | 0.6% |
| 40 | Manchester | 18,172 | 0.1% |
| 41 | Kirksville | 17,566 | 0.0% |
| 42 | Hannibal | 17,533 | -0.3% |
| 43 | Poplar Bluff | 17,043 | 0.0% |
| 44 | Clayton | 16,826 | 0.7% |
| 45 | Republic | 16,510 | 1.4% |
| 46 | Lake St. Louis | 16,230 | 1.4% |
| 47 | Sikeston | 16,108 | -0.2% |
| 48 | Overland | 15,637 | -0.3% |
| 49 | Jackson | 14,994 | 1.1% |
| 50 | Lebanon | 14,807 | 0.3% |
| 51 | Carthage | 14,763 | 0.3% |
| 52 | Jennings | 14,707 | -0.0% |
| 53 | Grain Valley | 14,277 | 1.3% |
| 54 | Washington | 14,055 | 0.1% |
| 55 | Moberly | 13,610 | -0.3% |
| 56 | Dardenne Prairie | 13,360 | 1.9% |
| 57 | Marshall | 12,934 | -0.1% |
| 58 | St. Ann | 12,709 | -0.3% |
| 59 | Fulton | 12,635 | -0.2% |
| 60 | Troy | 12,456 | 2.1% |
| 61 | West Plains | 12,257 | 0.3% |
| 62 | Neosho | 12,051 | 0.2% |
| 63 | Festus | 12,046 | 0.5% |
| 64 | Webb City | 11,887 | 1.0% |
| 65 | Crestwood | 11,850 | -0.1% |
| 66 | Union | 11,715 | 1.7% |
| 67 | Maryville | 11,687 | -0.3% |
| 68 | Excelsior Springs | 11,646 | 0.6% |
| 69 | Bridgeton | 11,600 | 0.1% |
| 70 | Branson | 11,567 | 1.2% |
| 71 | Mexico | 11,527 | -0.0% |
| 72 | Town and Country | 11,140 | 0.4% |
| 73 | Bolivar | 11,038 | 0.8% |
| 74 | Eureka | 10,759 | 0.7% |
| 75 | Kearney | 10,457 | 2.8% |
| 76 | Bellefontaine Neighbors | 10,456 | -0.5% |
| 77 | Smithville | 10,249 | 2.5% |
| 78 | Kennett | 10,182 | -0.9% |
| 79 | Harrisonville | 10,088 | 0.1% |
| 80 | Ellisville | 9,872 | 1.0% |
| 81 | Cameron | 9,703 | -0.3% |
| 82 | Chillicothe | 9,673 | 0.2% |
| 83 | Monett | 9,118 | 0.3% |
| 84 | Clinton | 8,947 | -0.1% |
| 85 | Berkeley | 8,897 | -0.1% |
| 86 | Des Peres | 8,662 | 0.4% |
| 87 | Pleasant Hill | 8,639 | 0.8% |
| 88 | Ladue | 8,635 | 0.2% |
| 89 | Richmond Heights | 8,552 | -0.1% |
| 90 | Park Hills | 8,515 | -0.4% |
| 91 | Sunset Hills | 8,480 | -0.0% |
| 92 | Perryville | 8,440 | 0.3% |
| 93 | Boonville | 8,403 | 0.1% |
| 94 | Nevada | 8,254 | -0.2% |
| 95 | Warrenton | 8,208 | 0.5% |
| 96 | Oak Grove | 8,182 | 0.6% |
| 97 | Carl Junction | 8,153 | 1.1% |
| 98 | Maplewood | 8,099 | 0.1% |
| 99 | Brentwood | 7,998 | -0.1% |
| 100 | Dexter | 7,864 | – |
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