| Rank | City | 2015 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 470,800 | 0.6% |
| 2 | St. Louis | 317,419 | -0.1% |
| 3 | Springfield | 165,378 | 0.9% |
| 4 | Independence | 117,494 | 0.1% |
| 5 | Columbia | 116,906 | 1.9% |
| 6 | Lee's Summit | 93,864 | 0.7% |
| 7 | O'Fallon | 84,009 | 1.4% |
| 8 | St. Joseph | 76,967 | 0.1% |
| 9 | St. Charles | 68,090 | 0.9% |
| 10 | St. Peters | 56,076 | 1.6% |
| 11 | Blue Springs | 53,573 | 0.5% |
| 12 | Florissant | 52,303 | 0.1% |
| 13 | Joplin | 51,316 | 0.6% |
| 14 | Chesterfield | 47,777 | 0.2% |
| 15 | Jefferson City | 43,132 | 0.0% |
| 16 | Cape Girardeau | 39,167 | 0.8% |
| 17 | Wildwood | 35,820 | 0.2% |
| 18 | University City | 35,115 | -0.2% |
| 19 | Wentzville | 33,912 | 3.9% |
| 20 | Ballwin | 30,505 | 0.1% |
| 21 | Liberty | 30,376 | 1.0% |
| 22 | Raytown | 29,481 | -0.0% |
| 23 | Kirkwood | 27,660 | 0.1% |
| 24 | Maryland Heights | 27,405 | -0.1% |
| 25 | Gladstone | 26,800 | 1.3% |
| 26 | Hazelwood | 25,666 | -0.0% |
| 27 | Grandview | 25,290 | 0.8% |
| 28 | Webster Groves | 23,186 | 0.2% |
| 29 | Belton | 23,165 | 0.1% |
| 30 | Sedalia | 21,492 | 0.1% |
| 31 | Arnold | 21,243 | 0.5% |
| 32 | Ferguson | 21,086 | -0.1% |
| 33 | Nixa | 20,570 | 2.0% |
| 34 | Raymore | 19,963 | 1.0% |
| 35 | Warrensburg | 19,963 | 1.5% |
| 36 | Rolla | 19,926 | 0.5% |
| 37 | Ozark | 18,871 | 1.4% |
| 38 | Manchester | 18,197 | 0.1% |
| 39 | Farmington | 17,915 | 2.5% |
| 40 | Hannibal | 17,893 | -0.0% |
| 41 | Creve Coeur | 17,868 | 0.0% |
| 42 | Kirksville | 17,633 | 0.2% |
| 43 | Poplar Bluff | 17,242 | 0.3% |
| 44 | Sikeston | 16,370 | 0.1% |
| 45 | Overland | 15,985 | -0.1% |
| 46 | Clayton | 15,882 | -0.1% |
| 47 | Republic | 15,680 | 1.5% |
| 48 | Lake St. Louis | 15,014 | 0.8% |
| 49 | Jennings | 14,737 | 0.0% |
| 50 | Jackson | 14,677 | 1.6% |
| 51 | Lebanon | 14,650 | 0.3% |
| 52 | Carthage | 14,271 | -0.2% |
| 53 | Washington | 14,020 | 0.1% |
| 54 | Moberly | 13,890 | -0.2% |
| 55 | Grain Valley | 13,236 | 0.7% |
| 56 | Marshall | 13,042 | -0.0% |
| 57 | St. Ann | 12,955 | -0.1% |
| 58 | Fulton | 12,864 | 0.1% |
| 59 | Dardenne Prairie | 12,783 | 2.7% |
| 60 | West Plains | 12,275 | 0.6% |
| 61 | Neosho | 12,134 | 0.6% |
| 62 | Maryville | 12,007 | 0.1% |
| 63 | Crestwood | 11,951 | 0.1% |
| 64 | Festus | 11,885 | 0.6% |
| 65 | Bridgeton | 11,782 | 0.5% |
| 66 | Mexico | 11,664 | 0.3% |
| 67 | Excelsior Springs | 11,488 | 0.9% |
| 68 | Troy | 11,355 | 1.9% |
| 69 | Branson | 11,340 | 1.9% |
| 70 | Webb City | 11,075 | 0.2% |
| 71 | Town and Country | 10,975 | 0.4% |
| 72 | Union | 10,859 | 1.6% |
| 73 | Bellefontaine Neighbors | 10,807 | -0.1% |
| 74 | Kennett | 10,796 | -0.3% |
| 75 | Bolivar | 10,572 | 0.6% |
| 76 | Eureka | 10,543 | 0.9% |
| 77 | Harrisonville | 9,983 | -0.1% |
| 78 | Cameron | 9,762 | -0.4% |
| 79 | Chillicothe | 9,504 | -0.0% |
| 80 | Kearney | 9,261 | 2.5% |
| 81 | Ellisville | 9,253 | 0.3% |
| 82 | Smithville | 9,107 | 2.0% |
| 83 | Berkeley | 9,084 | 0.3% |
| 84 | Clinton | 9,015 | 0.0% |
| 85 | Monett | 8,934 | 0.2% |
| 86 | Park Hills | 8,618 | -0.4% |
| 87 | Ladue | 8,576 | 0.2% |
| 88 | Des Peres | 8,534 | 0.5% |
| 89 | Sunset Hills | 8,527 | 0.1% |
| 90 | Richmond Heights | 8,495 | -0.3% |
| 91 | Perryville | 8,394 | 0.5% |
| 92 | Boonville | 8,374 | 0.2% |
| 93 | Nevada | 8,295 | -0.3% |
| 94 | Pleasant Hill | 8,250 | 0.4% |
| 95 | Warrenton | 8,068 | 0.6% |
| 96 | Brentwood | 8,043 | -0.0% |
| 97 | Dexter | 7,969 | 0.3% |
| 98 | Maplewood | 7,959 | -0.3% |
| 99 | Oak Grove | 7,873 | 0.2% |
| 100 | Olivette | 7,845 | 0.3% |
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