| Rank | City | 2006 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 463,983 | 1.0% |
| 2 | St. Louis | 352,572 | 0.3% |
| 3 | Springfield | 152,583 | 0.0% |
| 4 | Independence | 118,967 | 0.9% |
| 5 | Columbia | 94,211 | 1.8% |
| 6 | Lee's Summit | 76,320 | 1.5% |
| 7 | St. Joseph | 75,766 | 0.5% |
| 8 | O'Fallon | 69,694 | 6.5% |
| 9 | St. Charles | 61,964 | 0.4% |
| 10 | St. Peters | 53,736 | 0.9% |
| 11 | Blue Springs | 53,090 | 1.8% |
| 12 | Florissant | 51,548 | -0.9% |
| 13 | Joplin | 47,234 | 0.7% |
| 14 | Chesterfield | 46,762 | -0.0% |
| 15 | Jefferson City | 40,286 | -0.1% |
| 16 | University City | 37,003 | -0.4% |
| 17 | Cape Girardeau | 36,217 | 0.4% |
| 18 | Wildwood | 34,680 | 1.0% |
| 19 | Ballwin | 30,337 | -0.6% |
| 20 | Liberty | 28,898 | 1.9% |
| 21 | Raytown | 27,503 | -1.9% |
| 22 | Gladstone | 27,154 | 0.6% |
| 23 | Kirkwood | 26,917 | -0.3% |
| 24 | Maryland Heights | 26,350 | -0.6% |
| 25 | Hazelwood | 25,408 | -0.6% |
| 26 | Belton | 23,934 | 1.8% |
| 27 | Grandview | 23,340 | -1.2% |
| 28 | Webster Groves | 22,799 | -0.4% |
| 29 | Ferguson | 21,362 | -0.9% |
| 30 | Sedalia | 20,403 | 0.1% |
| 31 | Arnold | 20,095 | 0.1% |
| 32 | Manchester | 18,865 | -0.3% |
| 33 | Warrensburg | 17,993 | 1.9% |
| 34 | Wentzville | 17,962 | 19.2% |
| 35 | Rolla | 17,714 | 1.4% |
| 36 | Hannibal | 17,474 | -0.3% |
| 37 | Kirksville | 17,014 | -0.3% |
| 38 | Sikeston | 16,906 | -0.1% |
| 39 | Poplar Bluff | 16,889 | -0.1% |
| 40 | Creve Coeur | 16,887 | 0.2% |
| 41 | Nixa | 16,060 | 5.3% |
| 42 | Overland | 16,009 | -1.0% |
| 43 | Clayton | 16,005 | 0.1% |
| 44 | Raymore | 15,314 | 6.3% |
| 45 | Bridgeton | 15,190 | -0.5% |
| 46 | Farmington | 15,183 | 1.7% |
| 47 | Ozark | 15,079 | 8.0% |
| 48 | Jennings | 14,853 | -0.8% |
| 49 | Washington | 13,974 | 1.0% |
| 50 | Moberly | 13,948 | 0.3% |
| 51 | Lebanon | 13,286 | 1.4% |
| 52 | Lake St. Louis | 13,172 | 5.2% |
| 53 | Carthage | 13,142 | 0.6% |
| 54 | Jackson | 12,962 | 1.6% |
| 55 | St. Ann | 12,919 | -0.8% |
| 56 | Fulton | 12,389 | 0.3% |
| 57 | Marshall | 12,237 | -0.7% |
| 58 | Crestwood | 11,631 | -0.4% |
| 59 | Excelsior Springs | 11,408 | 1.0% |
| 60 | West Plains | 11,273 | 0.6% |
| 61 | Republic | 11,262 | 4.6% |
| 62 | Neosho | 10,969 | 0.7% |
| 63 | Mexico | 10,903 | -0.7% |
| 64 | Kennett | 10,837 | -0.7% |
| 65 | Webb City | 10,791 | 1.8% |
| 66 | Town and Country | 10,752 | -0.2% |
| 67 | Festus | 10,709 | 1.7% |
| 68 | Maryville | 10,704 | 0.1% |
| 69 | Bellefontaine Neighbors | 10,528 | -1.0% |
| 70 | Bolivar | 10,230 | 2.1% |
| 71 | Harrisonville | 9,748 | 1.5% |
| 72 | Troy | 9,737 | 7.2% |
| 73 | Berkeley | 9,582 | -0.9% |
| 74 | Ellisville | 9,290 | 0.4% |
| 75 | Clinton | 9,278 | -0.1% |
| 76 | Richmond Heights | 9,271 | -0.7% |
| 77 | Cameron | 9,177 | -1.3% |
| 78 | Eureka | 8,910 | 2.8% |
| 79 | Maplewood | 8,772 | -1.0% |
| 80 | Boonville | 8,687 | 1.0% |
| 81 | Union | 8,687 | 2.4% |
| 82 | Chillicothe | 8,625 | -0.8% |
| 83 | Des Peres | 8,572 | -0.1% |
| 84 | Park Hills | 8,382 | 1.2% |
| 85 | Monett | 8,351 | 1.5% |
| 86 | Nevada | 8,336 | -0.6% |
| 87 | Sunset Hills | 8,332 | 0.1% |
| 88 | Grain Valley | 8,234 | 9.0% |
| 89 | Ladue | 8,226 | -0.4% |
| 90 | Perryville | 7,844 | 0.3% |
| 91 | Dexter | 7,590 | 0.1% |
| 92 | Olivette | 7,416 | -0.1% |
| 93 | Kearney | 7,375 | 5.5% |
| 94 | Brentwood | 7,328 | -0.9% |
| 95 | Branson | 7,306 | 1.0% |
| 96 | Aurora | 7,233 | 0.5% |
| 97 | Pacific | 7,077 | 1.3% |
| 98 | Smithville | 7,069 | 4.8% |
| 99 | Dardenne Prairie | 7,047 | 9.3% |
| 100 | Bonne Terre | 6,942 | 11.4% |
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