| Rank | City | 2005 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 458,618 | 0.9% |
| 2 | St. Louis | 350,705 | 0.3% |
| 3 | Springfield | 152,571 | 0.1% |
| 4 | Independence | 117,921 | 0.9% |
| 5 | Columbia | 91,712 | 1.6% |
| 6 | St. Joseph | 75,352 | 0.4% |
| 7 | Lee's Summit | 75,239 | 1.5% |
| 8 | O'Fallon | 67,147 | 7.2% |
| 9 | St. Charles | 61,209 | 0.2% |
| 10 | St. Peters | 53,454 | 0.9% |
| 11 | Florissant | 52,114 | -0.8% |
| 12 | Blue Springs | 51,910 | 1.7% |
| 13 | Chesterfield | 46,867 | 0.0% |
| 14 | Joplin | 46,791 | 0.6% |
| 15 | Jefferson City | 39,479 | -0.7% |
| 16 | University City | 37,324 | -0.3% |
| 17 | Cape Girardeau | 35,974 | 0.4% |
| 18 | Wildwood | 34,424 | 1.0% |
| 19 | Ballwin | 30,637 | -0.5% |
| 20 | Liberty | 28,459 | 1.9% |
| 21 | Raytown | 28,091 | -1.8% |
| 22 | Gladstone | 27,102 | 0.7% |
| 23 | Kirkwood | 27,037 | -0.3% |
| 24 | Maryland Heights | 26,617 | -0.5% |
| 25 | Hazelwood | 25,526 | -0.6% |
| 26 | Grandview | 23,782 | -1.0% |
| 27 | Belton | 23,764 | 2.0% |
| 28 | Webster Groves | 22,977 | -0.3% |
| 29 | Ferguson | 21,573 | -0.9% |
| 30 | Sedalia | 20,110 | -0.3% |
| 31 | Arnold | 19,915 | -0.1% |
| 32 | Manchester | 18,958 | -0.3% |
| 33 | Warrensburg | 17,625 | 1.8% |
| 34 | Hannibal | 17,475 | -0.4% |
| 35 | Rolla | 17,399 | 1.4% |
| 36 | Kirksville | 17,111 | -0.3% |
| 37 | Sikeston | 16,821 | -0.2% |
| 38 | Poplar Bluff | 16,719 | -0.4% |
| 39 | Creve Coeur | 16,561 | -0.3% |
| 40 | Overland | 16,198 | -0.9% |
| 41 | Clayton | 15,888 | -0.1% |
| 42 | Bridgeton | 15,312 | -0.4% |
| 43 | Jennings | 14,983 | -0.8% |
| 44 | Nixa | 14,901 | 4.7% |
| 45 | Farmington | 14,751 | 1.3% |
| 46 | Wentzville | 14,678 | 18.4% |
| 47 | Ozark | 14,372 | 8.8% |
| 48 | Raymore | 14,333 | 6.2% |
| 49 | Washington | 13,812 | 0.9% |
| 50 | Moberly | 13,765 | 0.0% |
| 51 | St. Ann | 13,063 | -0.8% |
| 52 | Carthage | 13,017 | 0.6% |
| 53 | Lebanon | 12,860 | 1.0% |
| 54 | Lake St. Louis | 12,786 | 5.7% |
| 55 | Jackson | 12,720 | 1.5% |
| 56 | Marshall | 12,286 | -0.8% |
| 57 | Fulton | 11,743 | -0.9% |
| 58 | Crestwood | 11,699 | -0.4% |
| 59 | Excelsior Springs | 11,292 | 0.9% |
| 60 | West Plains | 11,008 | 0.2% |
| 61 | Mexico | 10,900 | -0.9% |
| 62 | Neosho | 10,841 | 0.5% |
| 63 | Kennett | 10,819 | -0.9% |
| 64 | Town and Country | 10,797 | -0.2% |
| 65 | Maryville | 10,673 | 0.0% |
| 66 | Bellefontaine Neighbors | 10,649 | -1.0% |
| 67 | Webb City | 10,559 | 1.7% |
| 68 | Republic | 10,552 | 4.1% |
| 69 | Festus | 10,298 | 1.2% |
| 70 | Bolivar | 9,842 | 1.6% |
| 71 | Berkeley | 9,692 | -0.9% |
| 72 | Harrisonville | 9,610 | 1.5% |
| 73 | Ellisville | 9,352 | 0.7% |
| 74 | Richmond Heights | 9,337 | -0.7% |
| 75 | Clinton | 9,303 | -0.1% |
| 76 | Cameron | 9,261 | -1.4% |
| 77 | Maplewood | 8,874 | -0.9% |
| 78 | Troy | 8,832 | 6.5% |
| 79 | Eureka | 8,750 | 3.0% |
| 80 | Chillicothe | 8,695 | -0.8% |
| 81 | Des Peres | 8,562 | -0.1% |
| 82 | Boonville | 8,553 | 0.9% |
| 83 | Union | 8,421 | 2.2% |
| 84 | Nevada | 8,343 | -0.7% |
| 85 | Sunset Hills | 8,336 | 0.2% |
| 86 | Park Hills | 8,317 | 1.4% |
| 87 | Ladue | 8,262 | -0.4% |
| 88 | Monett | 8,187 | 1.4% |
| 89 | Perryville | 7,799 | 0.3% |
| 90 | Grain Valley | 7,671 | 9.4% |
| 91 | Dexter | 7,530 | -0.1% |
| 92 | Olivette | 7,419 | -0.1% |
| 93 | Brentwood | 7,407 | -0.9% |
| 94 | Aurora | 7,077 | 0.1% |
| 95 | Branson | 7,044 | 0.3% |
| 96 | Black Jack | 6,960 | 0.4% |
| 97 | Kearney | 6,957 | 5.4% |
| 98 | Pacific | 6,876 | 0.9% |
| 99 | St. John | 6,605 | -0.9% |
| 100 | Smithville | 6,583 | 4.2% |
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