| Rank | City | 2004 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 453,949 | 0.9% |
| 2 | St. Louis | 348,039 | 0.1% |
| 3 | Springfield | 152,471 | 0.1% |
| 4 | Independence | 116,704 | 0.9% |
| 5 | Columbia | 89,913 | 1.5% |
| 6 | St. Joseph | 74,881 | 0.4% |
| 7 | Lee's Summit | 74,025 | 1.4% |
| 8 | O'Fallon | 63,955 | 7.9% |
| 9 | St. Charles | 61,253 | 0.3% |
| 10 | St. Peters | 53,173 | 1.1% |
| 11 | Florissant | 52,641 | -0.8% |
| 12 | Blue Springs | 51,106 | 1.8% |
| 13 | Chesterfield | 46,917 | 0.0% |
| 14 | Joplin | 46,497 | 0.6% |
| 15 | Jefferson City | 40,130 | -0.4% |
| 16 | University City | 37,689 | -0.0% |
| 17 | Cape Girardeau | 35,686 | 0.2% |
| 18 | Wildwood | 34,114 | 1.0% |
| 19 | Ballwin | 30,877 | -0.5% |
| 20 | Raytown | 28,537 | -1.9% |
| 21 | Liberty | 27,921 | 1.9% |
| 22 | Kirkwood | 27,190 | -0.2% |
| 23 | Gladstone | 27,039 | 0.8% |
| 24 | Maryland Heights | 26,830 | -0.4% |
| 25 | Hazelwood | 25,709 | -0.6% |
| 26 | Grandview | 24,217 | -0.8% |
| 27 | Belton | 23,434 | 2.2% |
| 28 | Webster Groves | 23,151 | -0.1% |
| 29 | Ferguson | 21,792 | -0.9% |
| 30 | Sedalia | 20,089 | -0.4% |
| 31 | Arnold | 19,833 | -0.2% |
| 32 | Manchester | 19,031 | -0.2% |
| 33 | Hannibal | 17,577 | -0.3% |
| 34 | Warrensburg | 17,213 | 1.6% |
| 35 | Kirksville | 17,153 | -0.3% |
| 36 | Rolla | 17,141 | 1.3% |
| 37 | Sikeston | 16,822 | -0.3% |
| 38 | Poplar Bluff | 16,698 | -0.5% |
| 39 | Creve Coeur | 16,642 | -0.2% |
| 40 | Overland | 16,375 | -0.9% |
| 41 | Clayton | 15,976 | 0.1% |
| 42 | Bridgeton | 15,418 | -0.3% |
| 43 | Jennings | 15,093 | -0.8% |
| 44 | Farmington | 14,339 | 0.8% |
| 45 | Nixa | 14,317 | 4.9% |
| 46 | Moberly | 13,744 | 0.0% |
| 47 | Washington | 13,612 | 0.7% |
| 48 | St. Ann | 13,202 | -0.7% |
| 49 | Raymore | 13,140 | 5.2% |
| 50 | Ozark | 13,077 | 8.4% |
| 51 | Carthage | 12,952 | 0.6% |
| 52 | Lebanon | 12,650 | 0.8% |
| 53 | Jackson | 12,468 | 1.3% |
| 54 | Wentzville | 12,404 | 18.4% |
| 55 | Fulton | 12,280 | 0.3% |
| 56 | Marshall | 12,267 | -1.2% |
| 57 | Lake St. Louis | 12,215 | 6.1% |
| 58 | Crestwood | 11,754 | -0.3% |
| 59 | Excelsior Springs | 11,179 | 0.9% |
| 60 | Mexico | 10,989 | -0.9% |
| 61 | Kennett | 10,987 | -0.8% |
| 62 | West Plains | 10,939 | 0.0% |
| 63 | Town and Country | 10,838 | -0.1% |
| 64 | Bellefontaine Neighbors | 10,780 | -0.9% |
| 65 | Neosho | 10,754 | 0.5% |
| 66 | Maryville | 10,733 | 0.2% |
| 67 | Webb City | 10,287 | 1.4% |
| 68 | Republic | 10,241 | 4.4% |
| 69 | Festus | 9,999 | 0.6% |
| 70 | Cameron | 9,898 | 0.3% |
| 71 | Berkeley | 9,793 | -0.8% |
| 72 | Bolivar | 9,696 | 1.7% |
| 73 | Richmond Heights | 9,436 | -0.5% |
| 74 | Harrisonville | 9,426 | 1.4% |
| 75 | Clinton | 9,319 | -0.0% |
| 76 | Ellisville | 9,200 | 0.4% |
| 77 | Maplewood | 8,969 | -0.9% |
| 78 | Chillicothe | 8,766 | -0.7% |
| 79 | Des Peres | 8,582 | -0.1% |
| 80 | Eureka | 8,565 | 3.3% |
| 81 | Nevada | 8,379 | -0.8% |
| 82 | Boonville | 8,365 | 0.5% |
| 83 | Sunset Hills | 8,330 | 0.2% |
| 84 | Ladue | 8,322 | -0.3% |
| 85 | Troy | 8,276 | 6.4% |
| 86 | Union | 8,219 | 2.1% |
| 87 | Park Hills | 8,213 | 1.4% |
| 88 | Monett | 8,070 | 1.4% |
| 89 | Perryville | 7,760 | 0.2% |
| 90 | Dexter | 7,500 | -0.2% |
| 91 | Brentwood | 7,483 | -0.9% |
| 92 | Olivette | 7,462 | 0.0% |
| 93 | Aurora | 7,067 | 0.1% |
| 94 | Black Jack | 6,971 | 0.5% |
| 95 | Branson | 6,970 | 0.1% |
| 96 | Pacific | 6,790 | 0.7% |
| 97 | Grain Valley | 6,772 | 8.2% |
| 98 | St. John | 6,677 | -0.9% |
| 99 | Kearney | 6,631 | 5.5% |
| 100 | De Soto | 6,524 | 0.2% |
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