| Rank | City | 2002 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Kansas City | 445,550 | 0.7% |
| 2 | St. Louis | 350,240 | 1.0% |
| 3 | Springfield | 152,533 | 0.2% |
| 4 | Independence | 114,459 | 0.8% |
| 5 | Columbia | 87,145 | 1.3% |
| 6 | St. Joseph | 74,444 | 0.5% |
| 7 | Lee's Summit | 71,761 | 1.1% |
| 8 | St. Charles | 60,860 | 0.3% |
| 9 | O'Fallon | 56,763 | 11.5% |
| 10 | Florissant | 53,540 | -0.7% |
| 11 | St. Peters | 51,899 | 0.8% |
| 12 | Blue Springs | 49,538 | 2.2% |
| 13 | Chesterfield | 46,951 | 0.2% |
| 14 | Joplin | 45,858 | 0.5% |
| 15 | Jefferson City | 40,107 | -1.2% |
| 16 | University City | 37,946 | 0.6% |
| 17 | Cape Girardeau | 35,647 | 0.5% |
| 18 | Wildwood | 33,483 | 1.3% |
| 19 | Ballwin | 31,307 | -0.0% |
| 20 | Raytown | 29,542 | -2.3% |
| 21 | Kirkwood | 27,385 | 0.1% |
| 22 | Maryland Heights | 27,113 | -0.1% |
| 23 | Liberty | 27,101 | 2.8% |
| 24 | Gladstone | 26,707 | 1.2% |
| 25 | Hazelwood | 26,045 | -0.5% |
| 26 | Grandview | 24,199 | -2.3% |
| 27 | Webster Groves | 23,315 | 0.3% |
| 28 | Belton | 22,467 | 2.5% |
| 29 | Ferguson | 22,200 | -0.8% |
| 30 | Sedalia | 20,253 | -0.4% |
| 31 | Arnold | 19,874 | -0.4% |
| 32 | Manchester | 19,145 | -0.1% |
| 33 | Hannibal | 17,621 | -0.8% |
| 34 | Kirksville | 17,290 | -0.0% |
| 35 | Sikeston | 16,904 | -0.3% |
| 36 | Poplar Bluff | 16,827 | -0.8% |
| 37 | Creve Coeur | 16,728 | -0.2% |
| 38 | Warrensburg | 16,694 | 1.7% |
| 39 | Overland | 16,678 | -0.8% |
| 40 | Rolla | 16,540 | 0.3% |
| 41 | Clayton | 15,917 | -0.1% |
| 42 | Bridgeton | 15,501 | -0.3% |
| 43 | Jennings | 15,355 | -0.6% |
| 44 | Farmington | 13,958 | -0.2% |
| 45 | Moberly | 13,694 | -0.3% |
| 46 | Washington | 13,392 | 0.5% |
| 47 | St. Ann | 13,384 | -0.7% |
| 48 | Nixa | 12,991 | 4.6% |
| 49 | Carthage | 12,771 | 0.3% |
| 50 | Fulton | 12,531 | 2.8% |
| 51 | Lebanon | 12,504 | 1.1% |
| 52 | Marshall | 12,504 | -1.6% |
| 53 | Jackson | 12,163 | 1.4% |
| 54 | Raymore | 11,847 | 5.1% |
| 55 | Crestwood | 11,847 | -0.2% |
| 56 | Mexico | 11,202 | -0.8% |
| 57 | Kennett | 11,147 | -0.8% |
| 58 | Excelsior Springs | 11,075 | 1.8% |
| 59 | Ozark | 11,052 | 7.7% |
| 60 | Bellefontaine Neighbors | 11,005 | -0.6% |
| 61 | Town and Country | 10,883 | 0.1% |
| 62 | West Plains | 10,876 | -0.5% |
| 63 | Maryville | 10,717 | 0.4% |
| 64 | Neosho | 10,557 | -0.5% |
| 65 | Lake St. Louis | 10,495 | 2.5% |
| 66 | Webb City | 10,010 | 1.5% |
| 67 | Berkeley | 9,975 | -0.7% |
| 68 | Festus | 9,841 | 0.1% |
| 69 | Cameron | 9,805 | 0.1% |
| 70 | Richmond Heights | 9,511 | -0.8% |
| 71 | Bolivar | 9,359 | 1.5% |
| 72 | Clinton | 9,353 | 0.2% |
| 73 | Republic | 9,291 | 3.3% |
| 74 | Harrisonville | 9,172 | 1.4% |
| 75 | Maplewood | 9,141 | -0.8% |
| 76 | Ellisville | 9,138 | 0.4% |
| 77 | Chillicothe | 8,918 | -0.5% |
| 78 | Des Peres | 8,612 | 0.2% |
| 79 | Wentzville | 8,558 | 14.6% |
| 80 | Nevada | 8,542 | -0.5% |
| 81 | Ladue | 8,396 | -0.1% |
| 82 | Sunset Hills | 8,308 | 0.4% |
| 83 | Boonville | 8,274 | 0.3% |
| 84 | Eureka | 8,125 | 4.5% |
| 85 | Park Hills | 8,087 | 2.6% |
| 86 | Union | 7,859 | 1.8% |
| 87 | Monett | 7,781 | 0.4% |
| 88 | Perryville | 7,700 | -0.2% |
| 89 | Brentwood | 7,621 | -0.8% |
| 90 | Dexter | 7,532 | -0.3% |
| 91 | Olivette | 7,502 | 0.7% |
| 92 | Troy | 7,270 | 5.9% |
| 93 | Aurora | 7,050 | 0.0% |
| 94 | Branson | 6,916 | -0.5% |
| 95 | Black Jack | 6,911 | 0.7% |
| 96 | St. John | 6,805 | -0.8% |
| 97 | Pacific | 6,712 | 1.1% |
| 98 | Caruthersville | 6,660 | -1.2% |
| 99 | Shrewsbury | 6,592 | -0.6% |
| 100 | Valley Park | 6,480 | -0.5% |
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