| Rank | City | 2010 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 129,333 | 0.9% |
| 2 | Charleston | 115,638 | 1.7% |
| 3 | North Charleston | 97,601 | 2.0% |
| 4 | Rock Hill | 69,210 | 3.5% |
| 5 | Mount Pleasant | 66,418 | 3.5% |
| 6 | Greenville | 61,782 | 1.0% |
| 7 | Summerville | 45,239 | 5.4% |
| 8 | Spartanburg | 40,387 | 0.1% |
| 9 | Goose Creek | 39,064 | 2.4% |
| 10 | Sumter | 38,412 | -0.6% |
| 11 | Hilton Head Island | 34,249 | 0.1% |
| 12 | Florence | 32,180 | 0.2% |
| 13 | Myrtle Beach | 31,968 | 3.1% |
| 14 | Aiken | 29,494 | 1.3% |
| 15 | Anderson | 27,181 | 0.5% |
| 16 | Greer | 25,775 | 4.1% |
| 17 | Greenwood | 22,710 | 0.2% |
| 18 | Mauldin | 22,379 | 4.1% |
| 19 | North Augusta | 20,880 | 1.8% |
| 20 | Easley | 20,540 | 1.4% |
| 21 | Simpsonville | 17,778 | 2.0% |
| 22 | Lexington | 16,321 | 4.8% |
| 23 | Conway | 16,317 | 2.8% |
| 24 | Hanahan | 16,253 | 2.5% |
| 25 | North Myrtle Beach | 16,221 | 4.1% |
| 26 | West Columbia | 14,061 | 0.6% |
| 27 | Orangeburg | 13,206 | 0.3% |
| 28 | Gaffney | 13,126 | 0.1% |
| 29 | Cayce | 13,062 | 0.7% |
| 30 | Clemson | 13,002 | 1.0% |
| 31 | Bluffton | 12,519 | 20.7% |
| 32 | Beaufort | 12,120 | -0.5% |
| 33 | Irmo | 11,942 | 0.7% |
| 34 | Port Royal | 11,421 | 2.2% |
| 35 | Newberry | 11,061 | 0.7% |
| 36 | Fort Mill | 10,701 | 3.2% |
| 37 | Lancaster | 10,160 | 2.3% |
| 38 | Forest Acres | 9,913 | -0.6% |
| 39 | Laurens | 9,478 | -0.3% |
| 40 | Bennettsville | 8,985 | -0.6% |
| 41 | Clinton | 8,923 | -0.3% |
| 42 | Georgetown | 8,441 | -0.7% |
| 43 | York | 8,189 | 1.8% |
| 44 | Union | 7,908 | -1.2% |
| 45 | Fountain Inn | 7,870 | 2.6% |
| 46 | Seneca | 7,832 | 0.2% |
| 47 | Hartsville | 7,342 | -0.3% |
| 48 | Moncks Corner | 7,266 | 1.8% |
| 49 | Camden | 7,103 | 0.7% |
| 50 | Lake City | 6,691 | 0.4% |
| 51 | Marion | 6,678 | -0.6% |
| 52 | Darlington | 6,504 | -0.5% |
| 53 | Dillon | 6,467 | -0.1% |
| 54 | Chester | 5,958 | -0.9% |
| 55 | Walterboro | 5,791 | 0.9% |
| 56 | Batesburg-Leesville | 5,653 | 0.2% |
| 57 | Abbeville | 5,476 | -0.8% |
| 58 | Cheraw | 5,386 | -0.4% |
| 59 | Tega Cay | 5,184 | 2.2% |
| 60 | Clover | 5,158 | 2.8% |
| 61 | Surfside Beach | 4,838 | 1.0% |
| 62 | Barnwell | 4,733 | -0.5% |
| 63 | Isle of Palms | 4,717 | 0.3% |
| 64 | Belton | 4,683 | 0.5% |
| 65 | Hollywood | 4,656 | 1.3% |
| 66 | Mullins | 4,628 | -0.9% |
| 67 | Travelers Rest | 4,622 | 1.4% |
| 68 | Edgefield | 4,360 | -0.2% |
| 69 | Woodruff | 4,174 | -0.2% |
| 70 | Central | 4,079 | 1.2% |
| 71 | Williamston | 3,993 | 0.5% |
| 72 | Manning | 3,867 | -0.4% |
| 73 | Bishopville | 3,761 | 0.3% |
| 74 | Honea Path | 3,713 | 0.5% |
| 75 | Winnsboro | 3,630 | -0.6% |
| 76 | Hardeeville | 3,580 | 6.0% |
| 77 | Allendale | 3,554 | -1.5% |
| 78 | Walhalla | 3,503 | -0.9% |
| 79 | Bamberg | 3,336 | -1.2% |
| 80 | Duncan | 3,228 | 0.9% |
| 81 | Kingstree | 3,176 | -1.4% |
| 82 | Pendleton | 3,153 | 0.6% |
| 83 | Williston | 3,133 | -0.5% |
| 84 | Fairfax | 3,088 | -0.4% |
| 85 | Liberty | 3,070 | 0.2% |
| 86 | Lyman | 3,039 | 0.9% |
| 87 | Pickens | 3,036 | -0.0% |
| 88 | Saluda | 2,986 | -0.3% |
| 89 | Andrews | 2,971 | -0.4% |
| 90 | Denmark | 2,934 | -1.3% |
| 91 | Pacolet | 2,870 | 0.5% |
| 92 | Blackville | 2,819 | -0.6% |
| 93 | Springdale | 2,801 | 0.6% |
| 94 | Hampton | 2,737 | -0.4% |
| 95 | Burnettown | 2,692 | 0.3% |
| 96 | McCormick | 2,685 | 0.1% |
| 97 | Landrum | 2,672 | 0.8% |
| 98 | Westminster | 2,658 | -0.4% |
| 99 | Wellford | 2,598 | 0.8% |
| 100 | Ridgeland | 2,579 | -0.2% |
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