| Rank | City | 2009 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 127,849 | 0.9% |
| 2 | Charleston | 113,511 | 1.7% |
| 3 | North Charleston | 95,089 | 1.9% |
| 4 | Rock Hill | 67,891 | 3.7% |
| 5 | Mount Pleasant | 65,326 | 3.7% |
| 6 | Greenville | 60,321 | 0.8% |
| 7 | Summerville | 44,546 | 5.8% |
| 8 | Spartanburg | 39,997 | -0.0% |
| 9 | Sumter | 38,401 | -0.7% |
| 10 | Goose Creek | 37,859 | 2.3% |
| 11 | Hilton Head Island | 34,243 | 0.1% |
| 12 | Florence | 32,063 | 0.2% |
| 13 | Myrtle Beach | 31,032 | 3.2% |
| 14 | Aiken | 29,220 | 1.4% |
| 15 | Anderson | 26,967 | 0.5% |
| 16 | Greer | 24,812 | 4.2% |
| 17 | Greenwood | 22,572 | 0.1% |
| 18 | Mauldin | 21,904 | 4.3% |
| 19 | North Augusta | 20,576 | 1.9% |
| 20 | Easley | 20,301 | 1.4% |
| 21 | Simpsonville | 17,365 | 2.0% |
| 22 | Hanahan | 16,101 | 2.7% |
| 23 | Conway | 15,901 | 2.8% |
| 24 | North Myrtle Beach | 15,840 | 4.3% |
| 25 | Lexington | 15,836 | 5.1% |
| 26 | West Columbia | 13,883 | 0.5% |
| 27 | Orangeburg | 13,286 | 0.4% |
| 28 | Gaffney | 13,110 | 0.1% |
| 29 | Clemson | 12,973 | 1.1% |
| 30 | Cayce | 12,710 | 0.5% |
| 31 | Bluffton | 12,333 | 23.4% |
| 32 | Beaufort | 12,068 | -0.7% |
| 33 | Irmo | 11,755 | 0.5% |
| 34 | Port Royal | 11,207 | 2.3% |
| 35 | Newberry | 10,914 | 0.7% |
| 36 | Fort Mill | 10,277 | 3.1% |
| 37 | Lancaster | 9,959 | 2.3% |
| 38 | Forest Acres | 9,874 | -0.7% |
| 39 | Laurens | 9,483 | -0.3% |
| 40 | Bennettsville | 8,951 | -0.8% |
| 41 | Clinton | 8,934 | -0.3% |
| 42 | Georgetown | 8,486 | -0.8% |
| 43 | York | 8,062 | 1.8% |
| 44 | Union | 7,998 | -1.2% |
| 45 | Seneca | 7,956 | 0.4% |
| 46 | Fountain Inn | 7,742 | 2.7% |
| 47 | Hartsville | 7,378 | -0.3% |
| 48 | Moncks Corner | 7,220 | 1.9% |
| 49 | Camden | 7,037 | 0.6% |
| 50 | Marion | 6,762 | -0.5% |
| 51 | Lake City | 6,669 | 0.4% |
| 52 | Darlington | 6,535 | -0.5% |
| 53 | Dillon | 6,438 | -0.1% |
| 54 | Chester | 6,023 | -0.9% |
| 55 | Walterboro | 5,809 | 1.0% |
| 56 | Batesburg-Leesville | 5,593 | 0.1% |
| 57 | Abbeville | 5,510 | -0.8% |
| 58 | Cheraw | 5,397 | -0.4% |
| 59 | Tega Cay | 5,033 | 2.1% |
| 60 | Clover | 5,003 | 2.7% |
| 61 | Surfside Beach | 4,797 | 1.0% |
| 62 | Barnwell | 4,780 | -0.5% |
| 63 | Mullins | 4,697 | -0.8% |
| 64 | Isle of Palms | 4,688 | 0.3% |
| 65 | Belton | 4,643 | 0.5% |
| 66 | Hollywood | 4,611 | 1.3% |
| 67 | Travelers Rest | 4,550 | 1.4% |
| 68 | Edgefield | 4,349 | -0.2% |
| 69 | Woodruff | 4,150 | -0.3% |
| 70 | Central | 4,082 | 1.3% |
| 71 | Williamston | 3,958 | 0.5% |
| 72 | Manning | 3,896 | -0.4% |
| 73 | Bishopville | 3,829 | 0.5% |
| 74 | Honea Path | 3,683 | 0.5% |
| 75 | Winnsboro | 3,653 | -0.6% |
| 76 | Allendale | 3,633 | -1.4% |
| 77 | Walhalla | 3,565 | -0.8% |
| 78 | Bamberg | 3,375 | -1.2% |
| 79 | Kingstree | 3,198 | -1.5% |
| 80 | Duncan | 3,186 | 0.9% |
| 81 | Williston | 3,167 | -0.4% |
| 82 | Fairfax | 3,147 | -0.2% |
| 83 | Pendleton | 3,126 | 0.6% |
| 84 | Hardeeville | 3,073 | 4.8% |
| 85 | Liberty | 3,069 | 0.2% |
| 86 | Pickens | 3,029 | -0.0% |
| 87 | Lyman | 2,998 | 0.8% |
| 88 | Andrews | 2,991 | -0.3% |
| 89 | Denmark | 2,974 | -1.3% |
| 90 | Saluda | 2,972 | -0.4% |
| 91 | Blackville | 2,841 | -0.5% |
| 92 | Pacolet | 2,836 | 0.4% |
| 93 | Hampton | 2,739 | -0.4% |
| 94 | Springdale | 2,726 | 0.4% |
| 95 | Burnettown | 2,677 | 0.2% |
| 96 | McCormick | 2,664 | 0.0% |
| 97 | Westminster | 2,661 | -0.4% |
| 98 | Landrum | 2,639 | 0.7% |
| 99 | Ridgeland | 2,604 | -0.1% |
| 100 | Wellford | 2,565 | 0.7% |
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