| Rank | City | 2008 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 125,963 | 0.8% |
| 2 | Charleston | 111,682 | 1.7% |
| 3 | North Charleston | 91,868 | 1.7% |
| 4 | Rock Hill | 65,274 | 3.7% |
| 5 | Mount Pleasant | 64,588 | 4.1% |
| 6 | Greenville | 59,170 | 0.6% |
| 7 | Summerville | 43,200 | 6.2% |
| 8 | Spartanburg | 39,202 | -0.3% |
| 9 | Sumter | 38,654 | -0.7% |
| 10 | Goose Creek | 36,246 | 2.0% |
| 11 | Hilton Head Island | 34,146 | 0.1% |
| 12 | Florence | 32,015 | 0.2% |
| 13 | Myrtle Beach | 30,304 | 3.3% |
| 14 | Aiken | 29,066 | 1.5% |
| 15 | Anderson | 26,664 | 0.4% |
| 16 | Greer | 23,593 | 4.0% |
| 17 | Greenwood | 22,296 | -0.1% |
| 18 | Mauldin | 20,346 | 3.8% |
| 19 | North Augusta | 20,186 | 1.9% |
| 20 | Easley | 20,013 | 1.4% |
| 21 | Simpsonville | 16,935 | 1.9% |
| 22 | Hanahan | 15,610 | 2.7% |
| 23 | North Myrtle Beach | 15,457 | 4.5% |
| 24 | Conway | 15,043 | 2.4% |
| 25 | Lexington | 15,029 | 5.0% |
| 26 | West Columbia | 13,826 | 0.5% |
| 27 | Orangeburg | 13,269 | 0.4% |
| 28 | Gaffney | 12,876 | -0.1% |
| 29 | Clemson | 12,769 | 1.1% |
| 30 | Cayce | 12,598 | 0.4% |
| 31 | Beaufort | 11,846 | -1.0% |
| 32 | Irmo | 11,598 | 0.4% |
| 33 | Newberry | 10,900 | 0.7% |
| 34 | Port Royal | 10,295 | 1.3% |
| 35 | Forest Acres | 9,886 | -0.8% |
| 36 | Lancaster | 9,718 | 2.3% |
| 37 | Fort Mill | 9,617 | 2.6% |
| 38 | Bluffton | 9,576 | 22.6% |
| 39 | Laurens | 9,473 | -0.3% |
| 40 | Bennettsville | 9,030 | -0.8% |
| 41 | Clinton | 8,891 | -0.4% |
| 42 | Georgetown | 8,488 | -0.9% |
| 43 | Union | 8,033 | -1.3% |
| 44 | Seneca | 8,026 | 0.6% |
| 45 | York | 7,809 | 1.6% |
| 46 | Fountain Inn | 7,499 | 2.7% |
| 47 | Hartsville | 7,389 | -0.3% |
| 48 | Camden | 7,020 | 0.7% |
| 49 | Moncks Corner | 7,001 | 1.8% |
| 50 | Marion | 6,788 | -0.5% |
| 51 | Lake City | 6,659 | 0.4% |
| 52 | Darlington | 6,516 | -0.6% |
| 53 | Dillon | 6,422 | -0.2% |
| 54 | Chester | 6,022 | -1.0% |
| 55 | Walterboro | 5,715 | 0.9% |
| 56 | Batesburg-Leesville | 5,546 | 0.0% |
| 57 | Abbeville | 5,538 | -0.8% |
| 58 | Cheraw | 5,393 | -0.5% |
| 59 | Tega Cay | 4,869 | 2.0% |
| 60 | Barnwell | 4,798 | -0.5% |
| 61 | Clover | 4,750 | 2.4% |
| 62 | Surfside Beach | 4,748 | 1.0% |
| 63 | Mullins | 4,714 | -0.9% |
| 64 | Isle of Palms | 4,677 | 0.3% |
| 65 | Belton | 4,595 | 0.4% |
| 66 | Hollywood | 4,556 | 1.3% |
| 67 | Travelers Rest | 4,474 | 1.4% |
| 68 | Edgefield | 4,349 | -0.3% |
| 69 | Woodruff | 4,122 | -0.5% |
| 70 | Central | 4,066 | 1.5% |
| 71 | Williamston | 3,917 | 0.4% |
| 72 | Manning | 3,892 | -0.5% |
| 73 | Bishopville | 3,845 | 0.7% |
| 74 | Allendale | 3,671 | -1.4% |
| 75 | Honea Path | 3,647 | 0.4% |
| 76 | Walhalla | 3,635 | -0.7% |
| 77 | Winnsboro | 3,631 | -0.7% |
| 78 | Bamberg | 3,420 | -1.2% |
| 79 | Kingstree | 3,236 | -1.5% |
| 80 | Williston | 3,180 | -0.5% |
| 81 | Duncan | 3,130 | 0.7% |
| 82 | Fairfax | 3,099 | -0.5% |
| 83 | Pendleton | 3,092 | 0.5% |
| 84 | Liberty | 3,052 | 0.2% |
| 85 | Denmark | 3,019 | -1.3% |
| 86 | Pickens | 3,010 | -0.1% |
| 87 | Saluda | 2,977 | -0.5% |
| 88 | Andrews | 2,958 | -0.5% |
| 89 | Lyman | 2,947 | 0.7% |
| 90 | Blackville | 2,856 | -0.5% |
| 91 | Pacolet | 2,790 | 0.3% |
| 92 | Hampton | 2,762 | -0.4% |
| 93 | Springdale | 2,691 | 0.2% |
| 94 | Burnettown | 2,670 | 0.2% |
| 95 | Westminster | 2,669 | -0.4% |
| 96 | McCormick | 2,665 | 0.0% |
| 97 | Ridgeland | 2,633 | 0.1% |
| 98 | Landrum | 2,596 | 0.6% |
| 99 | Wellford | 2,521 | 0.6% |
| 100 | Pageland | 2,503 | -0.1% |
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