| Rank | City | 2006 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 123,856 | 0.7% |
| 2 | Charleston | 109,786 | 2.1% |
| 3 | North Charleston | 88,394 | 1.6% |
| 4 | Mount Pleasant | 59,357 | 4.0% |
| 5 | Rock Hill | 59,285 | 3.1% |
| 6 | Greenville | 57,144 | 0.2% |
| 7 | Sumter | 39,352 | -0.6% |
| 8 | Spartanburg | 38,525 | -0.8% |
| 9 | Summerville | 37,402 | 5.8% |
| 10 | Hilton Head Island | 34,817 | 0.5% |
| 11 | Goose Creek | 32,140 | 0.4% |
| 12 | Florence | 31,787 | 0.2% |
| 13 | Aiken | 28,046 | 1.4% |
| 14 | Myrtle Beach | 27,343 | 2.5% |
| 15 | Anderson | 25,959 | -0.0% |
| 16 | Greenwood | 22,363 | -0.0% |
| 17 | Greer | 21,554 | 3.8% |
| 18 | Mauldin | 19,322 | 4.3% |
| 19 | North Augusta | 19,255 | 1.7% |
| 20 | Easley | 18,953 | 0.9% |
| 21 | Simpsonville | 15,634 | 1.0% |
| 22 | North Myrtle Beach | 14,380 | 4.9% |
| 23 | Conway | 13,844 | 1.7% |
| 24 | Hanahan | 13,757 | 1.1% |
| 25 | Lexington | 13,570 | 4.9% |
| 26 | Orangeburg | 13,545 | 1.0% |
| 27 | West Columbia | 13,427 | 0.1% |
| 28 | Gaffney | 12,820 | -0.2% |
| 29 | Beaufort | 12,426 | -0.5% |
| 30 | Clemson | 12,339 | 0.8% |
| 31 | Cayce | 12,336 | 0.2% |
| 32 | Irmo | 11,351 | 0.2% |
| 33 | Newberry | 10,505 | 0.3% |
| 34 | Forest Acres | 9,961 | -0.9% |
| 35 | Port Royal | 9,928 | 1.2% |
| 36 | Laurens | 9,458 | -0.5% |
| 37 | Lancaster | 9,336 | 2.4% |
| 38 | Bennettsville | 9,045 | -1.0% |
| 39 | Clinton | 8,939 | -0.4% |
| 40 | Georgetown | 8,755 | -0.6% |
| 41 | Fort Mill | 8,623 | 1.4% |
| 42 | Union | 8,222 | -1.3% |
| 43 | Seneca | 7,908 | 0.5% |
| 44 | Hartsville | 7,359 | -0.6% |
| 45 | York | 7,193 | 0.5% |
| 46 | Camden | 6,907 | 0.6% |
| 47 | Marion | 6,883 | -0.5% |
| 48 | Fountain Inn | 6,877 | 2.0% |
| 49 | Moncks Corner | 6,718 | 1.6% |
| 50 | Lake City | 6,608 | 0.4% |
| 51 | Darlington | 6,550 | -0.7% |
| 52 | Dillon | 6,401 | -0.3% |
| 53 | Chester | 6,102 | -1.1% |
| 54 | Bluffton | 5,952 | 21.0% |
| 55 | Abbeville | 5,634 | -0.8% |
| 56 | Walterboro | 5,606 | 0.9% |
| 57 | Batesburg-Leesville | 5,510 | -0.1% |
| 58 | Cheraw | 5,407 | -0.6% |
| 59 | Barnwell | 4,816 | -0.6% |
| 60 | Surfside Beach | 4,787 | 1.5% |
| 61 | Mullins | 4,771 | -1.0% |
| 62 | Isle of Palms | 4,668 | 0.4% |
| 63 | Hollywood | 4,586 | 2.0% |
| 64 | Belton | 4,518 | 0.2% |
| 65 | Tega Cay | 4,479 | 1.1% |
| 66 | Edgefield | 4,411 | -0.1% |
| 67 | Clover | 4,273 | 1.1% |
| 68 | Travelers Rest | 4,225 | 0.7% |
| 69 | Woodruff | 4,110 | -0.7% |
| 70 | Central | 4,061 | 2.0% |
| 71 | Manning | 3,928 | -0.4% |
| 72 | Williamston | 3,849 | 0.2% |
| 73 | Allendale | 3,802 | -1.3% |
| 74 | Winnsboro | 3,724 | -0.5% |
| 75 | Bishopville | 3,715 | 0.2% |
| 76 | Walhalla | 3,704 | -0.6% |
| 77 | Honea Path | 3,586 | 0.3% |
| 78 | Bamberg | 3,500 | -1.2% |
| 79 | Kingstree | 3,261 | -2.0% |
| 80 | Williston | 3,193 | -0.6% |
| 81 | Fairfax | 3,169 | -0.2% |
| 82 | Denmark | 3,095 | -1.4% |
| 83 | Andrews | 3,041 | -0.2% |
| 84 | Pendleton | 3,036 | 0.3% |
| 85 | Duncan | 3,036 | 0.4% |
| 86 | Liberty | 3,006 | -0.0% |
| 87 | Pickens | 2,983 | -0.4% |
| 88 | Saluda | 2,964 | -0.8% |
| 89 | Blackville | 2,883 | -0.6% |
| 90 | Lyman | 2,860 | 0.3% |
| 91 | Hampton | 2,738 | -0.7% |
| 92 | Pacolet | 2,710 | -0.2% |
| 93 | McCormick | 2,672 | 0.1% |
| 94 | Springdale | 2,659 | 0.1% |
| 95 | Westminster | 2,658 | -0.7% |
| 96 | Burnettown | 2,632 | 0.0% |
| 97 | Ridgeland | 2,604 | -0.1% |
| 98 | Landrum | 2,523 | 0.3% |
| 99 | Pageland | 2,489 | -0.2% |
| 100 | Wellford | 2,454 | 0.3% |
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