| Rank | City | 2005 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 126,529 | 1.5% |
| 2 | Charleston | 108,110 | 2.2% |
| 3 | North Charleston | 86,138 | 1.3% |
| 4 | Mount Pleasant | 57,878 | 4.3% |
| 5 | Rock Hill | 57,795 | 3.3% |
| 6 | Greenville | 56,740 | 0.0% |
| 7 | Sumter | 39,843 | -0.5% |
| 8 | Spartanburg | 38,712 | -0.9% |
| 9 | Hilton Head Island | 34,633 | 0.5% |
| 10 | Summerville | 34,061 | 4.8% |
| 11 | Goose Creek | 32,628 | 0.8% |
| 12 | Florence | 31,662 | 0.1% |
| 13 | Aiken | 27,586 | 1.3% |
| 14 | Myrtle Beach | 26,116 | 1.9% |
| 15 | Anderson | 25,898 | -0.1% |
| 16 | Greenwood | 22,426 | 0.0% |
| 17 | Greer | 20,614 | 3.6% |
| 18 | North Augusta | 18,958 | 1.7% |
| 19 | Easley | 18,763 | 0.9% |
| 20 | Mauldin | 18,656 | 4.5% |
| 21 | Simpsonville | 15,404 | 0.9% |
| 22 | Conway | 13,592 | 1.6% |
| 23 | Hanahan | 13,480 | 0.9% |
| 24 | Orangeburg | 13,390 | 0.9% |
| 25 | North Myrtle Beach | 13,372 | 4.3% |
| 26 | West Columbia | 13,196 | -0.3% |
| 27 | Lexington | 12,930 | 4.9% |
| 28 | Gaffney | 12,806 | -0.3% |
| 29 | Cayce | 12,350 | 0.3% |
| 30 | Beaufort | 12,280 | -0.9% |
| 31 | Clemson | 11,957 | 0.2% |
| 32 | Irmo | 11,309 | 0.1% |
| 33 | Newberry | 10,488 | 0.3% |
| 34 | Forest Acres | 10,063 | -0.9% |
| 35 | Port Royal | 9,617 | 0.6% |
| 36 | Laurens | 9,449 | -0.7% |
| 37 | Bennettsville | 9,247 | -0.7% |
| 38 | Lancaster | 9,235 | 2.7% |
| 39 | Clinton | 8,952 | -0.5% |
| 40 | Georgetown | 8,859 | -0.4% |
| 41 | Fort Mill | 8,403 | 1.1% |
| 42 | Union | 8,252 | -1.6% |
| 43 | Seneca | 7,941 | 0.7% |
| 44 | Hartsville | 7,375 | -0.6% |
| 45 | York | 7,005 | 0.0% |
| 46 | Marion | 6,929 | -0.4% |
| 47 | Camden | 6,879 | 0.7% |
| 48 | Fountain Inn | 6,729 | 1.9% |
| 49 | Darlington | 6,584 | -0.8% |
| 50 | Lake City | 6,569 | 0.4% |
| 51 | Moncks Corner | 6,538 | 1.4% |
| 52 | Dillon | 6,438 | -0.3% |
| 53 | Chester | 6,183 | -1.1% |
| 54 | Abbeville | 5,720 | -0.7% |
| 55 | Walterboro | 5,561 | 0.9% |
| 56 | Batesburg-Leesville | 5,491 | -0.2% |
| 57 | Cheraw | 5,382 | -0.9% |
| 58 | Bluffton | 4,872 | 20.7% |
| 59 | Barnwell | 4,822 | -0.7% |
| 60 | Mullins | 4,797 | -1.1% |
| 61 | Isle of Palms | 4,672 | 0.5% |
| 62 | Surfside Beach | 4,657 | 1.2% |
| 63 | Hollywood | 4,563 | 2.3% |
| 64 | Belton | 4,500 | 0.2% |
| 65 | Edgefield | 4,373 | -0.3% |
| 66 | Tega Cay | 4,367 | 0.7% |
| 67 | Woodruff | 4,147 | -0.7% |
| 68 | Travelers Rest | 4,139 | 0.4% |
| 69 | Clover | 4,071 | 0.2% |
| 70 | Manning | 3,929 | -0.6% |
| 71 | Allendale | 3,855 | -1.3% |
| 72 | Williamston | 3,833 | 0.2% |
| 73 | Winnsboro | 3,767 | -0.3% |
| 74 | Central | 3,739 | 0.4% |
| 75 | Walhalla | 3,736 | -0.5% |
| 76 | Bishopville | 3,646 | -0.2% |
| 77 | Honea Path | 3,574 | 0.2% |
| 78 | Bamberg | 3,522 | -1.4% |
| 79 | Kingstree | 3,306 | -2.1% |
| 80 | Williston | 3,198 | -0.7% |
| 81 | Fairfax | 3,153 | -0.4% |
| 82 | Denmark | 3,116 | -1.5% |
| 83 | Andrews | 3,040 | -0.2% |
| 84 | Pendleton | 3,022 | 0.3% |
| 85 | Duncan | 3,018 | 0.4% |
| 86 | Pickens | 3,000 | -0.3% |
| 87 | Liberty | 2,994 | -0.1% |
| 88 | Saluda | 2,947 | -1.1% |
| 89 | Blackville | 2,889 | -0.7% |
| 90 | Lyman | 2,844 | 0.3% |
| 91 | Hampton | 2,752 | -0.7% |
| 92 | Pacolet | 2,695 | -0.4% |
| 93 | Westminster | 2,682 | -0.6% |
| 94 | Springdale | 2,637 | -0.1% |
| 95 | McCormick | 2,635 | -0.3% |
| 96 | Burnettown | 2,633 | 0.1% |
| 97 | Ridgeland | 2,595 | -0.2% |
| 98 | Landrum | 2,512 | 0.2% |
| 99 | Pageland | 2,488 | -0.3% |
| 100 | Wellford | 2,444 | 0.2% |
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