| Rank | City | 2004 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 123,257 | 1.1% |
| 2 | Charleston | 104,520 | 1.8% |
| 3 | North Charleston | 83,374 | 0.7% |
| 4 | Greenville | 56,587 | -0.1% |
| 5 | Rock Hill | 56,536 | 3.6% |
| 6 | Mount Pleasant | 56,213 | 4.8% |
| 7 | Sumter | 39,902 | -0.6% |
| 8 | Spartanburg | 39,074 | -0.9% |
| 9 | Hilton Head Island | 34,599 | 0.6% |
| 10 | Goose Creek | 32,138 | 0.6% |
| 11 | Summerville | 31,729 | 3.9% |
| 12 | Florence | 31,427 | -0.1% |
| 13 | Aiken | 27,014 | 1.1% |
| 14 | Anderson | 25,913 | -0.1% |
| 15 | Myrtle Beach | 25,319 | 1.5% |
| 16 | Greenwood | 22,494 | 0.2% |
| 17 | Greer | 19,814 | 3.5% |
| 18 | Easley | 18,493 | 0.7% |
| 19 | North Augusta | 18,435 | 1.3% |
| 20 | Mauldin | 17,828 | 4.4% |
| 21 | Simpsonville | 15,131 | 0.6% |
| 22 | Conway | 13,344 | 1.5% |
| 23 | Orangeburg | 13,259 | 0.9% |
| 24 | West Columbia | 13,180 | -0.5% |
| 25 | Hanahan | 13,123 | 0.3% |
| 26 | Gaffney | 12,797 | -0.4% |
| 27 | North Myrtle Beach | 12,694 | 3.9% |
| 28 | Cayce | 12,379 | 0.4% |
| 29 | Beaufort | 12,336 | -1.0% |
| 30 | Lexington | 12,322 | 4.9% |
| 31 | Clemson | 11,725 | -0.4% |
| 32 | Irmo | 11,290 | 0.1% |
| 33 | Newberry | 10,444 | 0.3% |
| 34 | Forest Acres | 10,182 | -0.8% |
| 35 | Port Royal | 9,643 | 0.9% |
| 36 | Laurens | 9,526 | -0.6% |
| 37 | Bennettsville | 9,374 | -0.5% |
| 38 | Lancaster | 9,016 | 2.8% |
| 39 | Clinton | 8,954 | -0.7% |
| 40 | Georgetown | 8,887 | -0.5% |
| 41 | Union | 8,379 | -1.6% |
| 42 | Fort Mill | 8,290 | 1.1% |
| 43 | Seneca | 7,675 | -0.2% |
| 44 | Hartsville | 7,471 | -0.4% |
| 45 | Marion | 6,953 | -0.4% |
| 46 | York | 6,932 | -0.3% |
| 47 | Camden | 6,844 | 0.7% |
| 48 | Darlington | 6,654 | -0.7% |
| 49 | Fountain Inn | 6,617 | 2.0% |
| 50 | Lake City | 6,522 | 0.2% |
| 51 | Dillon | 6,441 | -0.3% |
| 52 | Moncks Corner | 6,305 | 0.6% |
| 53 | Chester | 6,267 | -1.0% |
| 54 | Abbeville | 5,763 | -0.6% |
| 55 | Batesburg-Leesville | 5,500 | -0.2% |
| 56 | Walterboro | 5,493 | 0.8% |
| 57 | Cheraw | 5,424 | -0.9% |
| 58 | Barnwell | 4,871 | -0.6% |
| 59 | Mullins | 4,824 | -1.3% |
| 60 | Isle of Palms | 4,604 | 0.2% |
| 61 | Surfside Beach | 4,527 | 0.6% |
| 62 | Hollywood | 4,492 | 2.6% |
| 63 | Belton | 4,490 | 0.1% |
| 64 | Edgefield | 4,396 | -0.3% |
| 65 | Tega Cay | 4,291 | 0.3% |
| 66 | Woodruff | 4,182 | -0.6% |
| 67 | Travelers Rest | 4,039 | -0.3% |
| 68 | Clover | 3,971 | -0.5% |
| 69 | Manning | 3,925 | -0.8% |
| 70 | Bluffton | 3,918 | 19.5% |
| 71 | Allendale | 3,883 | -1.5% |
| 72 | Williamston | 3,824 | 0.2% |
| 73 | Walhalla | 3,781 | -0.3% |
| 74 | Winnsboro | 3,746 | -0.6% |
| 75 | Central | 3,640 | -0.3% |
| 76 | Bishopville | 3,637 | -0.3% |
| 77 | Honea Path | 3,566 | 0.2% |
| 78 | Bamberg | 3,554 | -1.5% |
| 79 | Kingstree | 3,353 | -2.4% |
| 80 | Williston | 3,232 | -0.5% |
| 81 | Fairfax | 3,222 | 0.2% |
| 82 | Denmark | 3,148 | -1.7% |
| 83 | Andrews | 3,017 | -0.6% |
| 84 | Pendleton | 3,014 | 0.3% |
| 85 | Pickens | 3,012 | -0.3% |
| 86 | Duncan | 3,008 | 0.4% |
| 87 | Saluda | 2,994 | -1.0% |
| 88 | Liberty | 2,991 | -0.2% |
| 89 | Blackville | 2,927 | -0.5% |
| 90 | Lyman | 2,835 | 0.2% |
| 91 | Hampton | 2,783 | -0.6% |
| 92 | Westminster | 2,733 | -0.2% |
| 93 | Pacolet | 2,728 | -0.1% |
| 94 | McCormick | 2,688 | 0.3% |
| 95 | Springdale | 2,631 | -0.2% |
| 96 | Burnettown | 2,628 | 0.0% |
| 97 | Ridgeland | 2,594 | -0.3% |
| 98 | Landrum | 2,507 | 0.2% |
| 99 | Pageland | 2,498 | -0.3% |
| 100 | McColl | 2,444 | -0.7% |
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