| Rank | City | 2003 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 121,400 | 0.8% |
| 2 | Charleston | 102,187 | 1.6% |
| 3 | North Charleston | 82,287 | 0.4% |
| 4 | Greenville | 56,766 | 0.0% |
| 5 | Rock Hill | 54,955 | 4.0% |
| 6 | Mount Pleasant | 54,365 | 5.5% |
| 7 | Sumter | 40,182 | -0.6% |
| 8 | Spartanburg | 39,576 | -0.7% |
| 9 | Hilton Head Island | 34,626 | 1.0% |
| 10 | Goose Creek | 31,650 | 0.1% |
| 11 | Florence | 31,415 | -0.2% |
| 12 | Summerville | 30,185 | 3.3% |
| 13 | Aiken | 26,647 | 0.9% |
| 14 | Anderson | 26,060 | 0.1% |
| 15 | Myrtle Beach | 25,188 | 2.1% |
| 16 | Greenwood | 22,368 | -0.0% |
| 17 | Greer | 19,153 | 3.5% |
| 18 | Easley | 18,392 | 0.8% |
| 19 | North Augusta | 18,125 | 1.1% |
| 20 | Mauldin | 16,966 | 4.1% |
| 21 | Simpsonville | 15,055 | 0.7% |
| 22 | West Columbia | 13,204 | -0.6% |
| 23 | Orangeburg | 13,025 | 0.5% |
| 24 | Hanahan | 12,930 | -0.2% |
| 25 | Gaffney | 12,917 | -0.1% |
| 26 | Conway | 12,862 | 0.5% |
| 27 | Beaufort | 12,823 | 0.4% |
| 28 | Cayce | 12,383 | 0.7% |
| 29 | North Myrtle Beach | 12,258 | 4.1% |
| 30 | Clemson | 11,761 | -0.4% |
| 31 | Lexington | 11,678 | 4.6% |
| 32 | Irmo | 11,246 | -0.1% |
| 33 | Newberry | 10,466 | 0.5% |
| 34 | Forest Acres | 10,256 | -0.8% |
| 35 | Laurens | 9,556 | -0.8% |
| 36 | Bennettsville | 9,448 | -0.4% |
| 37 | Port Royal | 9,392 | 0.1% |
| 38 | Clinton | 8,998 | -0.8% |
| 39 | Georgetown | 8,923 | -0.5% |
| 40 | Lancaster | 8,867 | 3.3% |
| 41 | Union | 8,532 | -1.5% |
| 42 | Fort Mill | 8,092 | 0.4% |
| 43 | Seneca | 7,718 | 0.0% |
| 44 | Hartsville | 7,495 | -0.5% |
| 45 | York | 7,039 | 0.3% |
| 46 | Marion | 6,981 | -0.4% |
| 47 | Camden | 6,822 | 1.0% |
| 48 | Darlington | 6,700 | -0.7% |
| 49 | Lake City | 6,520 | 0.3% |
| 50 | Fountain Inn | 6,519 | 2.2% |
| 51 | Dillon | 6,465 | -0.3% |
| 52 | Chester | 6,338 | -0.9% |
| 53 | Moncks Corner | 6,292 | 0.8% |
| 54 | Abbeville | 5,798 | -0.7% |
| 55 | Batesburg-Leesville | 5,487 | -0.5% |
| 56 | Cheraw | 5,477 | -0.9% |
| 57 | Walterboro | 5,294 | -0.6% |
| 58 | Barnwell | 4,876 | -0.9% |
| 59 | Mullins | 4,852 | -1.7% |
| 60 | Isle of Palms | 4,582 | 0.1% |
| 61 | Belton | 4,493 | 0.2% |
| 62 | Surfside Beach | 4,475 | 0.4% |
| 63 | Hollywood | 4,422 | 3.1% |
| 64 | Edgefield | 4,394 | -0.4% |
| 65 | Tega Cay | 4,251 | 0.0% |
| 66 | Woodruff | 4,221 | -0.5% |
| 67 | Travelers Rest | 4,069 | -0.0% |
| 68 | Allendale | 3,952 | -1.3% |
| 69 | Manning | 3,946 | -0.9% |
| 70 | Clover | 3,939 | -1.2% |
| 71 | Williamston | 3,825 | 0.2% |
| 72 | Walhalla | 3,821 | 0.1% |
| 73 | Winnsboro | 3,786 | -0.4% |
| 74 | Bishopville | 3,653 | -0.3% |
| 75 | Central | 3,653 | -0.3% |
| 76 | Bamberg | 3,619 | -1.4% |
| 77 | Honea Path | 3,565 | 0.3% |
| 78 | Kingstree | 3,441 | -2.3% |
| 79 | Bluffton | 3,293 | 19.7% |
| 80 | Williston | 3,233 | -0.8% |
| 81 | Denmark | 3,222 | -1.4% |
| 82 | Fairfax | 3,195 | -0.1% |
| 83 | Andrews | 3,044 | -0.4% |
| 84 | Saluda | 3,029 | -0.8% |
| 85 | Pickens | 3,024 | -0.3% |
| 86 | Pendleton | 3,012 | 0.4% |
| 87 | Liberty | 3,000 | -0.2% |
| 88 | Duncan | 2,999 | 0.4% |
| 89 | Blackville | 2,928 | -0.7% |
| 90 | Lyman | 2,829 | 0.2% |
| 91 | Hampton | 2,784 | -0.8% |
| 92 | Westminster | 2,763 | 0.3% |
| 93 | Pacolet | 2,759 | 0.4% |
| 94 | McCormick | 2,677 | 0.3% |
| 95 | Springdale | 2,626 | -0.4% |
| 96 | Burnettown | 2,625 | -0.0% |
| 97 | Ridgeland | 2,602 | -0.3% |
| 98 | Landrum | 2,502 | 0.2% |
| 99 | Pageland | 2,499 | -0.4% |
| 100 | McColl | 2,464 | -0.7% |
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