| Rank | City | 2002 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Columbia | 122,073 | 2.3% |
| 2 | Charleston | 100,186 | 1.2% |
| 3 | North Charleston | 81,500 | -0.2% |
| 4 | Greenville | 57,018 | 0.5% |
| 5 | Rock Hill | 53,133 | 4.6% |
| 6 | Mount Pleasant | 52,044 | 6.5% |
| 7 | Sumter | 40,104 | -1.3% |
| 8 | Spartanburg | 39,800 | -0.8% |
| 9 | Hilton Head Island | 34,056 | 0.2% |
| 10 | Goose Creek | 31,722 | 0.5% |
| 11 | Florence | 31,308 | -0.7% |
| 12 | Summerville | 29,129 | 3.0% |
| 13 | Aiken | 26,286 | 0.5% |
| 14 | Anderson | 26,056 | 0.2% |
| 15 | Myrtle Beach | 25,091 | 3.8% |
| 16 | Greenwood | 22,298 | -0.4% |
| 17 | Greer | 18,444 | 3.1% |
| 18 | Easley | 18,267 | 0.8% |
| 19 | North Augusta | 17,826 | 0.5% |
| 20 | Mauldin | 16,166 | 3.3% |
| 21 | Simpsonville | 14,972 | 0.9% |
| 22 | West Columbia | 13,295 | -0.5% |
| 23 | Orangeburg | 12,985 | 0.6% |
| 24 | Hanahan | 12,934 | -0.5% |
| 25 | Gaffney | 12,900 | -0.4% |
| 26 | Conway | 12,802 | 0.4% |
| 27 | Beaufort | 12,200 | -4.1% |
| 28 | Cayce | 12,157 | -0.5% |
| 29 | Clemson | 11,804 | -0.5% |
| 30 | North Myrtle Beach | 11,755 | 3.8% |
| 31 | Irmo | 11,221 | -0.3% |
| 32 | Lexington | 11,155 | 4.6% |
| 33 | Newberry | 10,392 | 0.4% |
| 34 | Forest Acres | 10,295 | -1.3% |
| 35 | Laurens | 9,616 | -0.9% |
| 36 | Bennettsville | 9,402 | -1.3% |
| 37 | Port Royal | 9,362 | -0.1% |
| 38 | Clinton | 9,093 | -0.5% |
| 39 | Georgetown | 8,923 | -1.0% |
| 40 | Union | 8,642 | -1.7% |
| 41 | Lancaster | 8,563 | 3.1% |
| 42 | Fort Mill | 7,978 | -0.7% |
| 43 | Seneca | 7,688 | -0.3% |
| 44 | Hartsville | 7,512 | -0.7% |
| 45 | York | 6,989 | -0.1% |
| 46 | Marion | 6,986 | -0.8% |
| 47 | Darlington | 6,735 | -0.9% |
| 48 | Camden | 6,669 | -0.4% |
| 49 | Dillon | 6,501 | -0.1% |
| 50 | Lake City | 6,481 | 0.1% |
| 51 | Chester | 6,383 | -1.2% |
| 52 | Fountain Inn | 6,334 | 1.5% |
| 53 | Moncks Corner | 6,231 | 0.6% |
| 54 | Abbeville | 5,842 | -0.6% |
| 55 | Batesburg-Leesville | 5,518 | -0.3% |
| 56 | Cheraw | 5,476 | -1.8% |
| 57 | Walterboro | 5,304 | -1.1% |
| 58 | Barnwell | 4,932 | -0.7% |
| 59 | Mullins | 4,929 | -1.8% |
| 60 | Isle of Palms | 4,539 | -0.8% |
| 61 | Belton | 4,494 | 0.5% |
| 62 | Surfside Beach | 4,447 | 0.2% |
| 63 | Edgefield | 4,390 | -1.0% |
| 64 | Hollywood | 4,342 | 4.3% |
| 65 | Woodruff | 4,243 | -0.4% |
| 66 | Tega Cay | 4,226 | -0.5% |
| 67 | Travelers Rest | 4,069 | -0.0% |
| 68 | Allendale | 4,005 | -1.3% |
| 69 | Manning | 3,983 | -0.8% |
| 70 | Clover | 3,954 | -2.0% |
| 71 | Williamston | 3,825 | 0.5% |
| 72 | Walhalla | 3,805 | -0.1% |
| 73 | Winnsboro | 3,782 | -0.9% |
| 74 | Bishopville | 3,668 | -0.1% |
| 75 | Central | 3,658 | -0.4% |
| 76 | Bamberg | 3,656 | -1.7% |
| 77 | Honea Path | 3,564 | 0.6% |
| 78 | Kingstree | 3,520 | -2.3% |
| 79 | Williston | 3,267 | -0.5% |
| 80 | Denmark | 3,259 | -1.7% |
| 81 | Fairfax | 3,075 | -3.9% |
| 82 | Saluda | 3,053 | -0.9% |
| 83 | Andrews | 3,046 | -0.7% |
| 84 | Pickens | 3,030 | -0.3% |
| 85 | Pendleton | 3,009 | 0.7% |
| 86 | Liberty | 3,003 | -0.3% |
| 87 | Duncan | 2,987 | 0.5% |
| 88 | Blackville | 2,960 | -0.3% |
| 89 | Lyman | 2,820 | 0.2% |
| 90 | Hampton | 2,814 | -0.6% |
| 91 | Bluffton | 2,807 | 22.1% |
| 92 | Westminster | 2,749 | 0.1% |
| 93 | Pacolet | 2,748 | 0.4% |
| 94 | McCormick | 2,655 | -0.3% |
| 95 | Springdale | 2,634 | -0.5% |
| 96 | Burnettown | 2,622 | -0.2% |
| 97 | Ridgeland | 2,615 | -0.1% |
| 98 | Landrum | 2,497 | 0.3% |
| 99 | Pageland | 2,491 | -1.1% |
| 100 | McColl | 2,478 | -0.8% |
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