| Rank | City | 2023 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 202,016 | 2.2% |
| 2 | Rapid City | 78,716 | 2.9% |
| 3 | Aberdeen | 28,157 | -0.5% |
| 4 | Brookings | 24,003 | 1.2% |
| 5 | Watertown | 23,031 | 0.9% |
| 6 | Mitchell | 15,611 | -0.2% |
| 7 | Yankton | 15,557 | 0.5% |
| 8 | Huron | 14,539 | 1.0% |
| 9 | Pierre | 13,962 | -0.2% |
| 10 | Spearfish | 12,924 | 2.9% |
| 11 | Box Elder | 12,558 | 2.6% |
| 12 | Vermillion | 11,931 | 1.1% |
| 13 | Brandon | 11,104 | 0.5% |
| 14 | Harrisburg | 8,447 | 11.1% |
| 15 | Sturgis | 7,167 | 0.5% |
| 16 | Tea | 6,916 | 10.4% |
| 17 | Madison | 6,072 | -0.9% |
| 18 | Belle Fourche | 5,856 | 2.3% |
| 19 | Dell Rapids | 3,927 | -0.7% |
| 20 | Hot Springs | 3,608 | 3.5% |
| 21 | Milbank | 3,497 | 0.1% |
| 22 | Hartford | 3,428 | 1.2% |
| 23 | Mobridge | 3,238 | 0.5% |
| 24 | Canton | 3,071 | -0.1% |
| 25 | Summerset | 3,052 | 0.9% |
| 26 | North Sioux City | 3,026 | -0.3% |
| 27 | Lead | 3,017 | 0.7% |
| 28 | Winner | 2,891 | 0.4% |
| 29 | Chamberlain | 2,492 | 0.1% |
| 30 | Lennox | 2,466 | 0.8% |
| 31 | Sisseton | 2,408 | -1.2% |
| 32 | Flandreau | 2,358 | -0.3% |
| 33 | Volga | 2,272 | 4.0% |
| 34 | Redfield | 2,169 | -1.0% |
| 35 | Fort Pierre | 2,155 | 0.8% |
| 36 | Beresford | 2,129 | -1.1% |
| 37 | Elk Point | 2,101 | -0.8% |
| 38 | Springfield | 1,915 | -3.4% |
| 39 | Custer | 1,904 | -1.6% |
| 40 | Webster | 1,711 | -0.4% |
| 41 | Parkston | 1,532 | -0.6% |
| 42 | Wagner | 1,438 | -2.4% |
| 43 | Crooks | 1,382 | 1.1% |
| 44 | Groton | 1,377 | -0.3% |
| 45 | Salem | 1,335 | 0.3% |
| 46 | Miller | 1,329 | -0.2% |
| 47 | Baltic | 1,317 | 2.8% |
| 48 | Freeman | 1,308 | -0.7% |
| 49 | Platte | 1,253 | -2.4% |
| 50 | Deadwood | 1,246 | 4.1% |
| 51 | Eagle Butte | 1,241 | -0.8% |
| 52 | Parker | 1,225 | 0.7% |
| 53 | Clear Lake | 1,224 | 0.9% |
| 54 | Gregory | 1,222 | 0.8% |
| 55 | Britton | 1,217 | -0.2% |
| 56 | Garretson | 1,191 | -1.3% |
| 57 | Clark | 1,160 | 0.7% |
| 58 | Lemmon | 1,146 | -0.5% |
| 59 | Mission | 1,145 | – |
| 60 | Aurora | 1,133 | 3.9% |
| 61 | Gettysburg | 1,087 | -1.4% |
| 62 | Tyndall | 1,071 | 1.9% |
| 63 | De Smet | 1,058 | -0.3% |
| 64 | Piedmont | 1,032 | 3.0% |
| 65 | Hill City | 955 | 3.7% |
| 66 | Ipswich | 948 | 1.6% |
| 67 | Centerville | 947 | 1.7% |
| 68 | Worthing | 940 | 0.5% |
| 69 | Arlington | 933 | 0.7% |
| 70 | Martin | 933 | 0.4% |
| 71 | Whitewood | 930 | 2.3% |
| 72 | Valley Springs | 877 | 0.1% |
| 73 | Marion | 863 | 2.1% |
| 74 | Howard | 839 | -1.2% |
| 75 | Viborg | 826 | 1.7% |
| 76 | Faulkton | 822 | -0.4% |
| 77 | Eureka | 797 | -0.7% |
| 78 | Alcester | 795 | -1.1% |
| 79 | Scotland | 788 | 1.6% |
| 80 | Plankinton | 774 | – |
| 81 | Edgemont | 771 | 2.3% |
| 82 | Elkton | 768 | 1.1% |
| 83 | Wessington Springs | 766 | -1.8% |
| 84 | Estelline | 752 | -2.2% |
| 85 | Philip | 751 | 0.1% |
| 86 | Colton | 720 | -1.0% |
| 87 | Castlewood | 712 | 2.0% |
| 88 | Wall | 695 | -0.9% |
| 89 | Lake Andes | 691 | -1.4% |
| 90 | Armour | 690 | -0.7% |
| 91 | Onida | 657 | -0.4% |
| 92 | Alexandria | 656 | 4.8% |
| 93 | Woonsocket | 650 | -5.4% |
| 94 | Highmore | 644 | -2.0% |
| 95 | Colman | 643 | 0.8% |
| 96 | Canistota | 637 | -0.5% |
| 97 | Menno | 614 | -0.2% |
| 98 | New Underwood | 610 | 1.9% |
| 99 | Selby | 609 | -4.2% |
| 100 | Lake Preston | 605 | 1.3% |
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