| Rank | City | 2022 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 196,528 | 1.7% |
| 2 | Rapid City | 76,184 | 2.5% |
| 3 | Aberdeen | 28,324 | -0.4% |
| 4 | Brookings | 23,577 | 0.6% |
| 5 | Watertown | 22,722 | 0.5% |
| 6 | Mitchell | 15,631 | -0.3% |
| 7 | Yankton | 15,453 | 0.4% |
| 8 | Huron | 14,231 | -0.1% |
| 9 | Pierre | 14,000 | -0.2% |
| 10 | Spearfish | 12,358 | 1.3% |
| 11 | Box Elder | 12,310 | 3.2% |
| 12 | Vermillion | 11,802 | 1.1% |
| 13 | Brandon | 10,950 | -0.3% |
| 14 | Harrisburg | 7,638 | 11.6% |
| 15 | Sturgis | 7,107 | 0.2% |
| 16 | Tea | 6,256 | 10.2% |
| 17 | Madison | 6,071 | -1.7% |
| 18 | Belle Fourche | 5,699 | 1.7% |
| 19 | Dell Rapids | 3,953 | -0.7% |
| 20 | Hot Springs | 3,485 | 3.4% |
| 21 | Milbank | 3,474 | -0.5% |
| 22 | Hartford | 3,376 | 0.9% |
| 23 | Mobridge | 3,179 | -0.8% |
| 24 | Canton | 3,054 | -0.7% |
| 25 | Summerset | 3,027 | 1.1% |
| 26 | North Sioux City | 3,015 | -0.9% |
| 27 | Lead | 2,971 | -0.2% |
| 28 | Winner | 2,852 | -0.6% |
| 29 | Chamberlain | 2,468 | -0.7% |
| 30 | Sisseton | 2,428 | -1.6% |
| 31 | Lennox | 2,405 | -0.8% |
| 32 | Flandreau | 2,354 | -0.7% |
| 33 | Redfield | 2,188 | -1.2% |
| 34 | Fort Pierre | 2,162 | 2.0% |
| 35 | Volga | 2,151 | 2.5% |
| 36 | Beresford | 2,145 | -1.5% |
| 37 | Elk Point | 2,124 | -0.5% |
| 38 | Springfield | 2,053 | – |
| 39 | Custer | 1,949 | -0.9% |
| 40 | Webster | 1,707 | -1.0% |
| 41 | Parkston | 1,544 | -0.5% |
| 42 | Wagner | 1,467 | -2.8% |
| 43 | Groton | 1,382 | -0.2% |
| 44 | Crooks | 1,356 | 0.3% |
| 45 | Salem | 1,328 | 0.2% |
| 46 | Freeman | 1,322 | -0.4% |
| 47 | Miller | 1,318 | -1.2% |
| 48 | Platte | 1,279 | -2.8% |
| 49 | Baltic | 1,265 | 1.5% |
| 50 | Eagle Butte | 1,260 | – |
| 51 | Britton | 1,213 | -0.7% |
| 52 | Parker | 1,208 | -0.1% |
| 53 | Garretson | 1,202 | -1.6% |
| 54 | Deadwood | 1,201 | 4.5% |
| 55 | Clear Lake | 1,192 | -0.9% |
| 56 | Gregory | 1,189 | -1.2% |
| 57 | Lemmon | 1,154 | -0.3% |
| 58 | Mission | 1,146 | 0.1% |
| 59 | Clark | 1,141 | -0.2% |
| 60 | Gettysburg | 1,117 | -0.1% |
| 61 | Aurora | 1,071 | 2.1% |
| 62 | De Smet | 1,050 | -1.3% |
| 63 | Tyndall | 1,040 | 0.9% |
| 64 | Piedmont | 965 | -0.7% |
| 65 | Martin | 941 | 1.7% |
| 66 | Ipswich | 929 | 1.2% |
| 67 | Worthing | 928 | -0.2% |
| 68 | Centerville | 922 | 0.8% |
| 69 | Hill City | 922 | 3.8% |
| 70 | Arlington | 921 | 0.1% |
| 71 | Whitewood | 898 | 1.1% |
| 72 | Valley Springs | 871 | -0.5% |
| 73 | Howard | 864 | 0.5% |
| 74 | Marion | 833 | 0.6% |
| 75 | Faulkton | 829 | 0.1% |
| 76 | Eureka | 810 | 0.1% |
| 77 | Viborg | 802 | 0.4% |
| 78 | Alcester | 793 | -2.3% |
| 79 | Estelline | 786 | -0.1% |
| 80 | Wessington Springs | 781 | -1.8% |
| 81 | Plankinton | 778 | 0.5% |
| 82 | Scotland | 767 | 0.4% |
| 83 | Edgemont | 759 | 3.0% |
| 84 | Elkton | 753 | 0.3% |
| 85 | Woonsocket | 741 | 2.1% |
| 86 | Philip | 736 | -1.9% |
| 87 | Colton | 725 | -1.2% |
| 88 | Wall | 709 | 0.1% |
| 89 | Armour | 698 | -0.3% |
| 90 | Lake Andes | 690 | -3.0% |
| 91 | Castlewood | 690 | 0.9% |
| 92 | Onida | 668 | 0.9% |
| 93 | Selby | 660 | -0.6% |
| 94 | Highmore | 653 | -2.5% |
| 95 | Canistota | 643 | – |
| 96 | Colman | 629 | -0.6% |
| 97 | Menno | 618 | 0.3% |
| 98 | Lake Norden | 607 | 1.8% |
| 99 | Alexandria | 605 | 1.3% |
| 100 | New Underwood | 596 | 1.4% |
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