| Rank | City | 2010 Population | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 153,888 | 2.1% |
| 2 | Rapid City | 67,956 | 1.2% |
| 3 | Aberdeen | 26,091 | 0.4% |
| 4 | Brookings | 22,056 | 1.6% |
| 5 | Watertown | 21,482 | 0.6% |
| 6 | Mitchell | 15,254 | 0.4% |
| 7 | Yankton | 14,454 | 0.7% |
| 8 | Pierre | 13,646 | -0.2% |
| 9 | Huron | 12,592 | 0.6% |
| 10 | Vermillion | 10,571 | 0.3% |
| 11 | Spearfish | 10,494 | 1.9% |
| 12 | Brandon | 8,785 | 4.2% |
| 13 | Box Elder | 7,800 | 8.6% |
| 14 | Sturgis | 6,627 | 0.2% |
| 15 | Madison | 6,474 | -0.1% |
| 16 | Belle Fourche | 5,594 | 1.5% |
| 17 | Harrisburg | 4,089 | 15.3% |
| 18 | Tea | 3,806 | 7.8% |
| 19 | Hot Springs | 3,711 | -1.1% |
| 20 | Dell Rapids | 3,633 | 1.9% |
| 21 | Mobridge | 3,465 | -0.2% |
| 22 | Milbank | 3,353 | -0.8% |
| 23 | Lead | 3,124 | 0.3% |
| 24 | Canton | 3,057 | -0.3% |
| 25 | Winner | 2,897 | -0.7% |
| 26 | Hartford | 2,534 | 3.0% |
| 27 | North Sioux City | 2,530 | 1.0% |
| 28 | Sisseton | 2,470 | -0.3% |
| 29 | Chamberlain | 2,387 | 0.2% |
| 30 | Flandreau | 2,341 | -0.1% |
| 31 | Redfield | 2,333 | -0.8% |
| 32 | Lennox | 2,111 | 0.3% |
| 33 | Fort Pierre | 2,078 | 0.2% |
| 34 | Custer | 2,067 | 0.5% |
| 35 | Beresford | 2,005 | 0.0% |
| 36 | Springfield | 1,989 | 2.4% |
| 37 | Elk Point | 1,963 | 1.3% |
| 38 | Webster | 1,886 | -0.3% |
| 39 | Summerset | 1,814 | 18.4% |
| 40 | Volga | 1,768 | 2.0% |
| 41 | Wagner | 1,566 | -0.3% |
| 42 | Parkston | 1,508 | -1.0% |
| 43 | Miller | 1,489 | -0.3% |
| 44 | Groton | 1,458 | 0.8% |
| 45 | Salem | 1,347 | -0.3% |
| 46 | Eagle Butte | 1,318 | 3.8% |
| 47 | Freeman | 1,306 | -0.1% |
| 48 | Gregory | 1,295 | -0.7% |
| 49 | Clear Lake | 1,273 | -0.4% |
| 50 | Deadwood | 1,270 | -0.8% |
| 51 | Crooks | 1,269 | 3.9% |
| 52 | Britton | 1,241 | -0.7% |
| 53 | Platte | 1,230 | -1.0% |
| 54 | Lemmon | 1,227 | -1.2% |
| 55 | Mission | 1,182 | 2.7% |
| 56 | Garretson | 1,166 | -0.0% |
| 57 | Gettysburg | 1,162 | -1.4% |
| 58 | Clark | 1,139 | -1.1% |
| 59 | Baltic | 1,089 | 2.8% |
| 60 | De Smet | 1,089 | -1.0% |
| 61 | Martin | 1,071 | -0.1% |
| 62 | Tyndall | 1,067 | -1.5% |
| 63 | Parker | 1,022 | -0.2% |
| 64 | Wessington Springs | 956 | -0.5% |
| 65 | Ipswich | 954 | 0.1% |
| 66 | Hill City | 948 | 1.9% |
| 67 | Whitewood | 927 | 0.9% |
| 68 | Arlington | 915 | -0.8% |
| 69 | Centerville | 882 | -0.3% |
| 70 | Lake Andes | 879 | 0.7% |
| 71 | Worthing | 877 | 3.9% |
| 72 | Eureka | 868 | -2.3% |
| 73 | Howard | 858 | -2.2% |
| 74 | Scotland | 841 | -0.5% |
| 75 | Alcester | 807 | -0.9% |
| 76 | Highmore | 795 | -0.6% |
| 77 | Marion | 784 | -1.3% |
| 78 | Viborg | 782 | -0.6% |
| 79 | Philip | 779 | -1.2% |
| 80 | Edgemont | 774 | -1.0% |
| 81 | Estelline | 768 | 1.3% |
| 82 | Wall | 766 | -0.7% |
| 83 | Valley Springs | 759 | -0.5% |
| 84 | Elkton | 736 | 0.8% |
| 85 | Faulkton | 736 | -0.6% |
| 86 | St. Francis | 709 | 0.1% |
| 87 | Plankinton | 707 | 1.6% |
| 88 | Kimball | 703 | -0.5% |
| 89 | Armour | 699 | -1.1% |
| 90 | Colton | 687 | 0.4% |
| 91 | McLaughlin | 663 | -1.4% |
| 92 | New Underwood | 660 | 0.6% |
| 93 | Onida | 658 | -1.1% |
| 94 | Canistota | 656 | -0.7% |
| 95 | Woonsocket | 655 | -0.9% |
| 96 | Kadoka | 654 | -0.8% |
| 97 | Tripp | 647 | -1.0% |
| 98 | Selby | 642 | -1.3% |
| 99 | Castlewood | 627 | -0.6% |
| 100 | Alexandria | 615 | 0.8% |
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