| Rank | City | 2020 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 183,793 | 2.0% |
| 2 | Rapid City | 77,503 | 1.5% |
| 3 | Aberdeen | 28,257 | 0.9% |
| 4 | Brookings | 24,415 | 1.1% |
| 5 | Watertown | 22,174 | 0.4% |
| 6 | Mitchell | 15,679 | 0.3% |
| 7 | Yankton | 14,687 | 0.2% |
| 8 | Pierre | 13,867 | 0.2% |
| 9 | Huron | 13,380 | 0.7% |
| 10 | Spearfish | 11,756 | 1.3% |
| 11 | Vermillion | 10,926 | 0.4% |
| 12 | Box Elder | 10,119 | 2.9% |
| 13 | Brandon | 10,074 | 1.5% |
| 14 | Madison | 7,270 | 1.3% |
| 15 | Sturgis | 6,922 | 0.5% |
| 16 | Harrisburg | 6,710 | 5.7% |
| 17 | Tea | 6,031 | 5.2% |
| 18 | Belle Fourche | 5,702 | 0.2% |
| 19 | Dell Rapids | 3,628 | -0.0% |
| 20 | Canton | 3,560 | 1.7% |
| 21 | Hot Springs | 3,502 | -0.6% |
| 22 | Mobridge | 3,444 | -0.1% |
| 23 | Hartford | 3,354 | 3.2% |
| 24 | Milbank | 3,103 | -0.9% |
| 25 | Lead | 2,943 | -0.7% |
| 26 | North Sioux City | 2,928 | 1.6% |
| 27 | Winner | 2,824 | -0.3% |
| 28 | Summerset | 2,660 | 4.3% |
| 29 | Lennox | 2,479 | 1.8% |
| 30 | Sisseton | 2,398 | -0.3% |
| 31 | Chamberlain | 2,366 | -0.1% |
| 32 | Flandreau | 2,316 | -0.1% |
| 33 | Redfield | 2,273 | -0.3% |
| 34 | Fort Pierre | 2,217 | 0.7% |
| 35 | Volga | 2,028 | 1.5% |
| 36 | Beresford | 2,026 | 0.1% |
| 37 | Custer | 1,969 | -0.5% |
| 38 | Springfield | 1,922 | -0.4% |
| 39 | Elk Point | 1,871 | -0.5% |
| 40 | Webster | 1,726 | -1.0% |
| 41 | Wagner | 1,547 | -0.1% |
| 42 | Parkston | 1,477 | -0.2% |
| 43 | Groton | 1,475 | 0.1% |
| 44 | Eagle Butte | 1,346 | 0.2% |
| 45 | Miller | 1,334 | -1.2% |
| 46 | Crooks | 1,327 | 0.5% |
| 47 | Deadwood | 1,293 | 0.2% |
| 48 | Salem | 1,285 | -0.5% |
| 49 | Freeman | 1,275 | -0.3% |
| 50 | Britton | 1,273 | 0.3% |
| 51 | Clear Lake | 1,262 | -0.1% |
| 52 | Platte | 1,258 | 0.3% |
| 53 | Mission | 1,257 | 0.7% |
| 54 | Gregory | 1,242 | -0.5% |
| 55 | Baltic | 1,178 | 0.9% |
| 56 | Lemmon | 1,174 | -0.5% |
| 57 | Garretson | 1,147 | -0.2% |
| 58 | Gettysburg | 1,081 | -0.8% |
| 59 | Clark | 1,061 | -0.8% |
| 60 | De Smet | 1,052 | -0.4% |
| 61 | Martin | 1,045 | -0.3% |
| 62 | Hill City | 1,032 | 0.9% |
| 63 | Parker | 1,023 | 0.0% |
| 64 | Tyndall | 1,022 | -0.5% |
| 65 | Worthing | 1,007 | 1.5% |
| 66 | Whitewood | 979 | 0.6% |
| 67 | Wessington Springs | 911 | -0.5% |
| 68 | Piedmont | 903 | 16.9% |
| 69 | Ipswich | 891 | -0.8% |
| 70 | Wall | 875 | 1.5% |
| 71 | Centerville | 872 | -0.1% |
| 72 | Arlington | 859 | -0.7% |
| 73 | Aurora | 834 | 5.1% |
| 74 | Eureka | 826 | -0.5% |
| 75 | Lake Andes | 821 | -0.8% |
| 76 | Scotland | 804 | -0.5% |
| 77 | Marion | 780 | -0.1% |
| 78 | Viborg | 767 | -0.2% |
| 79 | Philip | 765 | -0.2% |
| 80 | Howard | 757 | -1.4% |
| 81 | Alcester | 755 | -0.7% |
| 82 | Estelline | 746 | -0.3% |
| 83 | Valley Springs | 730 | -0.4% |
| 84 | Plankinton | 730 | 0.4% |
| 85 | Elkton | 726 | -0.2% |
| 86 | Highmore | 726 | -1.0% |
| 87 | Edgemont | 719 | -0.8% |
| 88 | Kadoka | 717 | 1.0% |
| 89 | Faulkton | 709 | -0.4% |
| 90 | New Underwood | 673 | 0.2% |
| 91 | Kimball | 673 | -0.5% |
| 92 | Colton | 669 | -0.3% |
| 93 | Armour | 669 | -0.5% |
| 94 | McLaughlin | 653 | -0.2% |
| 95 | Woonsocket | 648 | -0.1% |
| 96 | Alexandria | 644 | 0.5% |
| 97 | Castlewood | 641 | 0.2% |
| 98 | Canistota | 636 | -0.3% |
| 99 | Onida | 634 | -0.4% |
| 100 | Selby | 627 | -0.3% |
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