| Rank | City | 2018 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 176,888 | 2.0% |
| 2 | Rapid City | 74,421 | 1.3% |
| 3 | Aberdeen | 28,388 | 1.2% |
| 4 | Brookings | 23,938 | 1.2% |
| 5 | Watertown | 22,222 | 0.5% |
| 6 | Mitchell | 15,603 | 0.3% |
| 7 | Yankton | 14,516 | 0.1% |
| 8 | Pierre | 14,004 | 0.4% |
| 9 | Huron | 13,118 | 0.6% |
| 10 | Spearfish | 11,609 | 1.5% |
| 11 | Vermillion | 10,772 | 0.3% |
| 12 | Brandon | 9,957 | 1.8% |
| 13 | Box Elder | 9,498 | 2.9% |
| 14 | Madison | 7,322 | 1.8% |
| 15 | Sturgis | 6,908 | 0.6% |
| 16 | Harrisburg | 5,968 | 5.6% |
| 17 | Belle Fourche | 5,553 | -0.1% |
| 18 | Tea | 5,448 | 5.3% |
| 19 | Dell Rapids | 3,652 | 0.1% |
| 20 | Mobridge | 3,520 | 0.2% |
| 21 | Hot Springs | 3,460 | -1.0% |
| 22 | Canton | 3,430 | 1.7% |
| 23 | Hartford | 3,237 | 3.6% |
| 24 | Milbank | 3,133 | -1.0% |
| 25 | Lead | 2,978 | -0.7% |
| 26 | Winner | 2,844 | -0.3% |
| 27 | North Sioux City | 2,784 | 1.4% |
| 28 | Summerset | 2,566 | 5.1% |
| 29 | Sisseton | 2,402 | -0.4% |
| 30 | Chamberlain | 2,389 | 0.0% |
| 31 | Lennox | 2,386 | 1.8% |
| 32 | Flandreau | 2,333 | -0.0% |
| 33 | Redfield | 2,295 | -0.2% |
| 34 | Fort Pierre | 2,150 | 0.5% |
| 35 | Beresford | 1,953 | -0.4% |
| 36 | Springfield | 1,942 | -0.3% |
| 37 | Custer | 1,932 | -1.0% |
| 38 | Volga | 1,932 | 1.3% |
| 39 | Elk Point | 1,828 | -1.0% |
| 40 | Webster | 1,773 | -0.9% |
| 41 | Wagner | 1,587 | 0.2% |
| 42 | Groton | 1,507 | 0.5% |
| 43 | Parkston | 1,497 | -0.1% |
| 44 | Miller | 1,376 | -1.1% |
| 45 | Eagle Butte | 1,345 | 0.3% |
| 46 | Crooks | 1,318 | 0.5% |
| 47 | Deadwood | 1,304 | 0.4% |
| 48 | Freeman | 1,289 | -0.2% |
| 49 | Salem | 1,277 | -0.8% |
| 50 | Platte | 1,272 | 0.5% |
| 51 | Gregory | 1,255 | -0.4% |
| 52 | Britton | 1,249 | 0.1% |
| 53 | Mission | 1,242 | 0.7% |
| 54 | Clear Lake | 1,241 | -0.4% |
| 55 | Lemmon | 1,213 | -0.2% |
| 56 | Garretson | 1,172 | 0.1% |
| 57 | Baltic | 1,171 | 1.0% |
| 58 | Gettysburg | 1,116 | -0.6% |
| 59 | Martin | 1,067 | -0.1% |
| 60 | De Smet | 1,067 | -0.3% |
| 61 | Clark | 1,047 | -1.2% |
| 62 | Tyndall | 1,044 | -0.3% |
| 63 | Hill City | 1,008 | 0.9% |
| 64 | Parker | 1,008 | -0.2% |
| 65 | Worthing | 978 | 1.6% |
| 66 | Whitewood | 947 | 0.3% |
| 67 | Ipswich | 926 | -0.4% |
| 68 | Wessington Springs | 921 | -0.5% |
| 69 | Wall | 872 | 1.9% |
| 70 | Centerville | 870 | -0.2% |
| 71 | Arlington | 862 | -0.8% |
| 72 | Piedmont | 848 | 21.1% |
| 73 | Eureka | 840 | -0.5% |
| 74 | Lake Andes | 837 | -0.7% |
| 75 | Scotland | 817 | -0.4% |
| 76 | Philip | 784 | 0.1% |
| 77 | Marion | 771 | -0.2% |
| 78 | Viborg | 770 | -0.2% |
| 79 | Howard | 767 | -1.6% |
| 80 | Valley Springs | 747 | -0.2% |
| 81 | Highmore | 738 | -1.1% |
| 82 | Alcester | 737 | -1.3% |
| 83 | Estelline | 736 | -0.6% |
| 84 | Faulkton | 725 | -0.2% |
| 85 | Plankinton | 720 | 0.3% |
| 86 | Elkton | 712 | -0.5% |
| 87 | Edgemont | 711 | -1.2% |
| 88 | Kadoka | 704 | 1.1% |
| 89 | Aurora | 691 | 3.8% |
| 90 | Woonsocket | 680 | 0.5% |
| 91 | Kimball | 680 | -0.5% |
| 92 | McLaughlin | 679 | 0.3% |
| 93 | Colton | 676 | -0.2% |
| 94 | Armour | 669 | -0.6% |
| 95 | New Underwood | 665 | 0.1% |
| 96 | Onida | 650 | -0.2% |
| 97 | Selby | 643 | 0.0% |
| 98 | Alexandria | 635 | 0.5% |
| 99 | Tripp | 632 | -0.3% |
| 100 | Castlewood | 626 | -0.0% |
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