| Rank | City | 2017 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 174,360 | 2.1% |
| 2 | Rapid City | 74,048 | 1.4% |
| 3 | Aberdeen | 28,415 | 1.4% |
| 4 | Brookings | 23,895 | 1.3% |
| 5 | Watertown | 22,172 | 0.5% |
| 6 | Mitchell | 15,729 | 0.5% |
| 7 | Yankton | 14,566 | 0.1% |
| 8 | Pierre | 14,008 | 0.4% |
| 9 | Huron | 13,117 | 0.7% |
| 10 | Spearfish | 11,531 | 1.6% |
| 11 | Vermillion | 10,844 | 0.4% |
| 12 | Brandon | 9,923 | 2.1% |
| 13 | Box Elder | 9,348 | 3.1% |
| 14 | Madison | 7,425 | 2.3% |
| 15 | Sturgis | 6,832 | 0.5% |
| 16 | Harrisburg | 5,734 | 5.8% |
| 17 | Belle Fourche | 5,655 | 0.2% |
| 18 | Tea | 5,032 | 4.8% |
| 19 | Dell Rapids | 3,705 | 0.3% |
| 20 | Mobridge | 3,570 | 0.5% |
| 21 | Hot Springs | 3,564 | -0.7% |
| 22 | Canton | 3,386 | 1.7% |
| 23 | Milbank | 3,203 | -0.8% |
| 24 | Hartford | 3,140 | 3.6% |
| 25 | Lead | 3,010 | -0.6% |
| 26 | Winner | 2,861 | -0.2% |
| 27 | North Sioux City | 2,731 | 1.3% |
| 28 | Sisseton | 2,429 | -0.3% |
| 29 | Summerset | 2,392 | 4.7% |
| 30 | Chamberlain | 2,369 | -0.1% |
| 31 | Redfield | 2,339 | 0.0% |
| 32 | Flandreau | 2,332 | -0.1% |
| 33 | Lennox | 2,330 | 1.7% |
| 34 | Fort Pierre | 2,148 | 0.6% |
| 35 | Beresford | 1,969 | -0.3% |
| 36 | Custer | 1,956 | -0.9% |
| 37 | Springfield | 1,950 | -0.3% |
| 38 | Volga | 1,910 | 1.3% |
| 39 | Elk Point | 1,851 | -1.0% |
| 40 | Webster | 1,808 | -0.7% |
| 41 | Wagner | 1,586 | 0.2% |
| 42 | Parkston | 1,511 | 0.0% |
| 43 | Groton | 1,509 | 0.6% |
| 44 | Miller | 1,420 | -0.8% |
| 45 | Eagle Butte | 1,349 | 0.4% |
| 46 | Crooks | 1,327 | 0.7% |
| 47 | Salem | 1,324 | -0.3% |
| 48 | Freeman | 1,308 | 0.0% |
| 49 | Platte | 1,273 | 0.6% |
| 50 | Deadwood | 1,264 | -0.1% |
| 51 | Britton | 1,250 | 0.1% |
| 52 | Gregory | 1,244 | -0.7% |
| 53 | Mission | 1,236 | 0.7% |
| 54 | Clear Lake | 1,226 | -0.6% |
| 55 | Lemmon | 1,216 | -0.1% |
| 56 | Garretson | 1,193 | 0.4% |
| 57 | Gettysburg | 1,155 | -0.1% |
| 58 | Baltic | 1,152 | 0.9% |
| 59 | De Smet | 1,077 | -0.2% |
| 60 | Martin | 1,071 | – |
| 61 | Tyndall | 1,049 | -0.3% |
| 62 | Clark | 1,048 | -1.4% |
| 63 | Hill City | 1,008 | 1.0% |
| 64 | Parker | 1,007 | -0.2% |
| 65 | Worthing | 957 | 1.5% |
| 66 | Ipswich | 951 | -0.1% |
| 67 | Whitewood | 931 | 0.1% |
| 68 | Wessington Springs | 921 | -0.6% |
| 69 | Arlington | 880 | -0.6% |
| 70 | Centerville | 879 | -0.1% |
| 71 | Wall | 872 | 2.2% |
| 72 | Piedmont | 860 | 25.3% |
| 73 | Eureka | 848 | -0.4% |
| 74 | Lake Andes | 841 | -0.7% |
| 75 | Scotland | 819 | -0.4% |
| 76 | Howard | 800 | -1.2% |
| 77 | Marion | 779 | -0.1% |
| 78 | Viborg | 774 | -0.2% |
| 79 | Philip | 765 | -0.3% |
| 80 | Valley Springs | 760 | 0.0% |
| 81 | Highmore | 754 | -0.9% |
| 82 | Estelline | 751 | -0.4% |
| 83 | Alcester | 748 | -1.3% |
| 84 | Faulkton | 747 | 0.2% |
| 85 | Edgemont | 736 | -0.8% |
| 86 | Elkton | 723 | -0.3% |
| 87 | Plankinton | 718 | 0.3% |
| 88 | Kadoka | 707 | 1.3% |
| 89 | Colton | 684 | -0.1% |
| 90 | Kimball | 679 | -0.6% |
| 91 | Armour | 678 | -0.5% |
| 92 | Woonsocket | 671 | 0.4% |
| 93 | New Underwood | 668 | 0.2% |
| 94 | Aurora | 667 | 3.8% |
| 95 | McLaughlin | 665 | 0.1% |
| 96 | Onida | 659 | 0.0% |
| 97 | Selby | 649 | 0.2% |
| 98 | Tripp | 638 | -0.2% |
| 99 | Canistota | 636 | -0.5% |
| 100 | Castlewood | 633 | 0.2% |
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