| Rank | City | 2015 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 168,586 | 2.3% |
| 2 | Rapid City | 72,638 | 1.7% |
| 3 | Aberdeen | 27,800 | 1.6% |
| 4 | Brookings | 23,225 | 1.3% |
| 5 | Watertown | 22,057 | 0.7% |
| 6 | Mitchell | 15,693 | 0.7% |
| 7 | Yankton | 14,552 | 0.2% |
| 8 | Pierre | 14,054 | 0.7% |
| 9 | Huron | 13,163 | 1.1% |
| 10 | Spearfish | 11,091 | 1.4% |
| 11 | Vermillion | 10,699 | 0.3% |
| 12 | Brandon | 9,779 | 2.7% |
| 13 | Box Elder | 9,233 | 4.3% |
| 14 | Madison | 7,126 | 2.4% |
| 15 | Sturgis | 6,741 | 0.4% |
| 16 | Belle Fourche | 5,707 | 0.5% |
| 17 | Harrisburg | 5,190 | 6.1% |
| 18 | Tea | 4,531 | 4.5% |
| 19 | Dell Rapids | 3,700 | 0.5% |
| 20 | Mobridge | 3,515 | 0.4% |
| 21 | Hot Springs | 3,503 | -1.4% |
| 22 | Canton | 3,317 | 2.1% |
| 23 | Milbank | 3,269 | -0.6% |
| 24 | Lead | 3,030 | -0.8% |
| 25 | Hartford | 2,983 | 4.2% |
| 26 | Winner | 2,862 | -0.3% |
| 27 | North Sioux City | 2,636 | 1.0% |
| 28 | Sisseton | 2,473 | 0.0% |
| 29 | Redfield | 2,416 | 0.9% |
| 30 | Chamberlain | 2,402 | 0.2% |
| 31 | Flandreau | 2,283 | -0.6% |
| 32 | Lennox | 2,264 | 1.8% |
| 33 | Fort Pierre | 2,135 | 0.7% |
| 34 | Summerset | 2,118 | 3.9% |
| 35 | Beresford | 2,025 | 0.2% |
| 36 | Custer | 1,969 | -1.2% |
| 37 | Springfield | 1,963 | -0.3% |
| 38 | Elk Point | 1,940 | -0.3% |
| 39 | Webster | 1,833 | -0.7% |
| 40 | Volga | 1,817 | 0.7% |
| 41 | Wagner | 1,576 | 0.2% |
| 42 | Groton | 1,495 | 0.6% |
| 43 | Parkston | 1,476 | -0.5% |
| 44 | Miller | 1,440 | -0.8% |
| 45 | Eagle Butte | 1,353 | 0.7% |
| 46 | Salem | 1,350 | 0.1% |
| 47 | Crooks | 1,330 | 1.2% |
| 48 | Freeman | 1,274 | -0.6% |
| 49 | Gregory | 1,264 | -0.6% |
| 50 | Deadwood | 1,261 | -0.2% |
| 51 | Platte | 1,248 | 0.4% |
| 52 | Clear Lake | 1,248 | -0.5% |
| 53 | Lemmon | 1,240 | 0.3% |
| 54 | Britton | 1,226 | -0.3% |
| 55 | Garretson | 1,212 | 1.0% |
| 56 | Mission | 1,208 | 0.5% |
| 57 | Gettysburg | 1,172 | 0.2% |
| 58 | Baltic | 1,135 | 1.0% |
| 59 | De Smet | 1,090 | 0.0% |
| 60 | Martin | 1,064 | -0.2% |
| 61 | Tyndall | 1,059 | -0.2% |
| 62 | Clark | 1,051 | -2.0% |
| 63 | Parker | 1,001 | -0.5% |
| 64 | Hill City | 990 | 1.1% |
| 65 | Ipswich | 950 | -0.1% |
| 66 | Worthing | 942 | 1.8% |
| 67 | Wessington Springs | 925 | -0.8% |
| 68 | Whitewood | 923 | -0.1% |
| 69 | Arlington | 899 | -0.4% |
| 70 | Wall | 882 | 3.6% |
| 71 | Centerville | 874 | -0.2% |
| 72 | Eureka | 850 | -0.5% |
| 73 | Piedmont | 835 | 39.3% |
| 74 | Lake Andes | 833 | -1.3% |
| 75 | Scotland | 830 | -0.3% |
| 76 | Howard | 819 | -1.2% |
| 77 | Alcester | 788 | -0.6% |
| 78 | Highmore | 779 | -0.5% |
| 79 | Valley Springs | 775 | 0.5% |
| 80 | Marion | 771 | -0.4% |
| 81 | Viborg | 767 | -0.5% |
| 82 | Estelline | 755 | -0.4% |
| 83 | Philip | 745 | -1.1% |
| 84 | Faulkton | 744 | 0.3% |
| 85 | Edgemont | 742 | -1.1% |
| 86 | Elkton | 729 | -0.2% |
| 87 | Plankinton | 718 | 0.4% |
| 88 | Kadoka | 699 | 1.7% |
| 89 | Kimball | 697 | -0.2% |
| 90 | Colton | 695 | 0.3% |
| 91 | Armour | 685 | -0.5% |
| 92 | McLaughlin | 677 | 0.5% |
| 93 | Onida | 675 | 0.6% |
| 94 | New Underwood | 674 | 0.5% |
| 95 | Canistota | 652 | -0.2% |
| 96 | Woonsocket | 652 | -0.1% |
| 97 | Selby | 644 | 0.1% |
| 98 | Alexandria | 631 | 0.6% |
| 99 | Tripp | 627 | -0.8% |
| 100 | Castlewood | 624 | -0.1% |
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