| Rank | City | 2014 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 164,676 | 2.3% |
| 2 | Rapid City | 70,812 | 1.4% |
| 3 | Aberdeen | 27,333 | 1.6% |
| 4 | Brookings | 22,943 | 1.3% |
| 5 | Watertown | 21,995 | 0.8% |
| 6 | Mitchell | 15,539 | 0.6% |
| 7 | Yankton | 14,591 | 0.3% |
| 8 | Pierre | 13,984 | 0.8% |
| 9 | Huron | 13,097 | 1.3% |
| 10 | Spearfish | 11,107 | 1.9% |
| 11 | Vermillion | 10,692 | 0.4% |
| 12 | Brandon | 9,532 | 2.8% |
| 13 | Box Elder | 9,093 | 5.2% |
| 14 | Madison | 6,949 | 2.4% |
| 15 | Sturgis | 6,883 | 1.3% |
| 16 | Belle Fourche | 5,725 | 0.8% |
| 17 | Harrisburg | 4,861 | 5.9% |
| 18 | Tea | 4,427 | 5.2% |
| 19 | Dell Rapids | 3,728 | 0.9% |
| 20 | Mobridge | 3,524 | 0.6% |
| 21 | Hot Springs | 3,514 | -1.8% |
| 22 | Milbank | 3,313 | -0.4% |
| 23 | Canton | 3,274 | 2.3% |
| 24 | Lead | 3,109 | -0.2% |
| 25 | Hartford | 2,926 | 4.9% |
| 26 | Winner | 2,853 | -0.5% |
| 27 | North Sioux City | 2,509 | -0.3% |
| 28 | Sisseton | 2,450 | -0.3% |
| 29 | Chamberlain | 2,444 | 0.8% |
| 30 | Redfield | 2,385 | 0.7% |
| 31 | Flandreau | 2,301 | -0.6% |
| 32 | Lennox | 2,234 | 1.9% |
| 33 | Fort Pierre | 2,120 | 0.7% |
| 34 | Beresford | 2,033 | 0.5% |
| 35 | Summerset | 2,029 | 3.8% |
| 36 | Custer | 2,013 | -0.9% |
| 37 | Springfield | 1,980 | -0.2% |
| 38 | Elk Point | 1,963 | – |
| 39 | Webster | 1,835 | -0.9% |
| 40 | Volga | 1,784 | 0.3% |
| 41 | Wagner | 1,573 | 0.1% |
| 42 | Groton | 1,487 | 0.7% |
| 43 | Parkston | 1,470 | -0.8% |
| 44 | Miller | 1,461 | -0.6% |
| 45 | Salem | 1,355 | 0.2% |
| 46 | Eagle Butte | 1,349 | 0.8% |
| 47 | Crooks | 1,334 | 1.7% |
| 48 | Deadwood | 1,288 | 0.5% |
| 49 | Gregory | 1,272 | -0.6% |
| 50 | Freeman | 1,262 | -1.1% |
| 51 | Britton | 1,261 | 0.5% |
| 52 | Clear Lake | 1,251 | -0.6% |
| 53 | Platte | 1,244 | 0.4% |
| 54 | Lemmon | 1,242 | 0.4% |
| 55 | Mission | 1,221 | 1.1% |
| 56 | Garretson | 1,216 | 1.4% |
| 57 | Gettysburg | 1,201 | 1.1% |
| 58 | Baltic | 1,147 | 1.7% |
| 59 | De Smet | 1,082 | -0.2% |
| 60 | Martin | 1,073 | 0.1% |
| 61 | Tyndall | 1,064 | -0.1% |
| 62 | Clark | 1,060 | -2.4% |
| 63 | Parker | 1,017 | -0.2% |
| 64 | Hill City | 974 | 0.9% |
| 65 | Ipswich | 960 | 0.2% |
| 66 | Wessington Springs | 952 | -0.1% |
| 67 | Whitewood | 940 | 0.5% |
| 68 | Worthing | 930 | 2.0% |
| 69 | Arlington | 894 | -0.8% |
| 70 | Centerville | 886 | 0.2% |
| 71 | Piedmont | 881 | 58.3% |
| 72 | Wall | 876 | 4.6% |
| 73 | Eureka | 864 | -0.2% |
| 74 | Scotland | 832 | -0.4% |
| 75 | Lake Andes | 831 | -1.9% |
| 76 | Howard | 822 | -1.4% |
| 77 | Alcester | 801 | -0.2% |
| 78 | Valley Springs | 781 | 1.0% |
| 79 | Highmore | 780 | -0.6% |
| 80 | Marion | 780 | -0.2% |
| 81 | Viborg | 778 | -0.2% |
| 82 | Philip | 762 | -0.7% |
| 83 | Estelline | 759 | -0.4% |
| 84 | Faulkton | 744 | 0.4% |
| 85 | Edgemont | 740 | -1.5% |
| 86 | Elkton | 733 | -0.1% |
| 87 | Plankinton | 715 | 0.4% |
| 88 | Kimball | 713 | 0.5% |
| 89 | Armour | 701 | 0.1% |
| 90 | Colton | 700 | 0.6% |
| 91 | Kadoka | 690 | 1.8% |
| 92 | McLaughlin | 683 | 1.0% |
| 93 | Onida | 681 | 1.2% |
| 94 | New Underwood | 674 | 0.7% |
| 95 | Canistota | 657 | 0.1% |
| 96 | Selby | 650 | 0.4% |
| 97 | Woonsocket | 648 | -0.4% |
| 98 | Alexandria | 626 | 0.6% |
| 99 | Tripp | 625 | -1.1% |
| 100 | Castlewood | 624 | -0.2% |
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