| Rank | City | 2012 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 156,627 | 1.8% |
| 2 | Rapid City | 68,671 | 1.1% |
| 3 | Aberdeen | 26,362 | 1.0% |
| 4 | Brookings | 22,228 | 0.8% |
| 5 | Watertown | 21,644 | 0.8% |
| 6 | Mitchell | 15,343 | 0.6% |
| 7 | Yankton | 14,495 | 0.3% |
| 8 | Pierre | 13,821 | 1.3% |
| 9 | Huron | 12,740 | 1.2% |
| 10 | Vermillion | 10,728 | 1.5% |
| 11 | Spearfish | 10,644 | 1.4% |
| 12 | Brandon | 9,082 | 3.4% |
| 13 | Box Elder | 8,475 | 8.7% |
| 14 | Madison | 6,702 | 3.5% |
| 15 | Sturgis | 6,555 | -1.1% |
| 16 | Belle Fourche | 5,696 | 1.8% |
| 17 | Harrisburg | 4,467 | 9.2% |
| 18 | Tea | 4,021 | 5.6% |
| 19 | Dell Rapids | 3,655 | 0.6% |
| 20 | Hot Springs | 3,570 | -3.8% |
| 21 | Mobridge | 3,544 | 2.3% |
| 22 | Milbank | 3,299 | -1.6% |
| 23 | Canton | 3,150 | 3.0% |
| 24 | Lead | 3,103 | -0.7% |
| 25 | Winner | 2,912 | 0.5% |
| 26 | Hartford | 2,664 | 5.1% |
| 27 | North Sioux City | 2,525 | -0.2% |
| 28 | Sisseton | 2,502 | 1.3% |
| 29 | Chamberlain | 2,412 | 1.0% |
| 30 | Redfield | 2,353 | 0.9% |
| 31 | Flandreau | 2,333 | -0.3% |
| 32 | Lennox | 2,160 | 2.3% |
| 33 | Fort Pierre | 2,122 | 2.1% |
| 34 | Beresford | 2,015 | 0.5% |
| 35 | Custer | 2,007 | -2.9% |
| 36 | Springfield | 1,981 | -0.4% |
| 37 | Elk Point | 1,975 | 0.6% |
| 38 | Webster | 1,902 | 0.8% |
| 39 | Summerset | 1,849 | 1.9% |
| 40 | Volga | 1,760 | -0.5% |
| 41 | Wagner | 1,573 | 0.4% |
| 42 | Miller | 1,492 | 0.2% |
| 43 | Parkston | 1,483 | -1.7% |
| 44 | Groton | 1,468 | 0.7% |
| 45 | Salem | 1,335 | -0.9% |
| 46 | Eagle Butte | 1,333 | 1.1% |
| 47 | Crooks | 1,283 | 1.1% |
| 48 | Freeman | 1,275 | -2.4% |
| 49 | Clear Lake | 1,275 | 0.2% |
| 50 | Gregory | 1,274 | -1.6% |
| 51 | Deadwood | 1,268 | -0.2% |
| 52 | Lemmon | 1,241 | 1.1% |
| 53 | Platte | 1,240 | 0.8% |
| 54 | Britton | 1,226 | -1.2% |
| 55 | Mission | 1,214 | 2.7% |
| 56 | Garretson | 1,185 | 1.6% |
| 57 | Gettysburg | 1,179 | 1.5% |
| 58 | Baltic | 1,116 | 2.5% |
| 59 | De Smet | 1,090 | 0.1% |
| 60 | Clark | 1,083 | -4.9% |
| 61 | Martin | 1,078 | 0.7% |
| 62 | Tyndall | 1,058 | -0.8% |
| 63 | Parker | 1,020 | -0.2% |
| 64 | Ipswich | 959 | 0.5% |
| 65 | Hill City | 957 | 0.9% |
| 66 | Wessington Springs | 955 | -0.1% |
| 67 | Whitewood | 934 | 0.8% |
| 68 | Arlington | 918 | 0.3% |
| 69 | Worthing | 898 | 2.4% |
| 70 | Centerville | 891 | 1.0% |
| 71 | Eureka | 859 | -1.0% |
| 72 | Howard | 839 | -2.2% |
| 73 | Scotland | 834 | -0.8% |
| 74 | Lake Andes | 826 | -6.0% |
| 75 | Wall | 806 | 5.2% |
| 76 | Alcester | 805 | -0.2% |
| 77 | Highmore | 784 | -1.4% |
| 78 | Marion | 783 | -0.1% |
| 79 | Viborg | 781 | -0.1% |
| 80 | Philip | 772 | -0.9% |
| 81 | Estelline | 766 | -0.3% |
| 82 | Valley Springs | 763 | 0.5% |
| 83 | Edgemont | 754 | -2.6% |
| 84 | Faulkton | 737 | 0.1% |
| 85 | Elkton | 731 | -0.7% |
| 86 | Plankinton | 713 | 0.8% |
| 87 | Kimball | 709 | 0.9% |
| 88 | Armour | 693 | -0.9% |
| 89 | Colton | 686 | -0.1% |
| 90 | Kadoka | 682 | 4.3% |
| 91 | McLaughlin | 664 | 0.2% |
| 92 | New Underwood | 661 | 0.2% |
| 93 | Onida | 659 | 0.2% |
| 94 | Woonsocket | 656 | 0.2% |
| 95 | Selby | 654 | 1.9% |
| 96 | Canistota | 648 | -1.2% |
| 97 | Tripp | 633 | -2.2% |
| 98 | Castlewood | 626 | -0.2% |
| 99 | Alexandria | 623 | 1.3% |
| 100 | Newell | 610 | 1.2% |
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