| Rank | City | 2008 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 151,761 | 2.7% |
| 2 | Rapid City | 64,389 | 1.0% |
| 3 | Aberdeen | 24,906 | -0.2% |
| 4 | Watertown | 20,500 | 0.2% |
| 5 | Brookings | 19,676 | 0.6% |
| 6 | Mitchell | 14,791 | 0.2% |
| 7 | Pierre | 14,074 | 0.2% |
| 8 | Yankton | 13,673 | 0.2% |
| 9 | Huron | 10,958 | -1.1% |
| 10 | Vermillion | 10,353 | 0.1% |
| 11 | Spearfish | 9,937 | 2.0% |
| 12 | Brandon | 7,383 | 3.5% |
| 13 | Madison | 6,413 | -0.2% |
| 14 | Sturgis | 6,027 | -1.0% |
| 15 | Belle Fourche | 4,935 | 0.4% |
| 16 | Harrisburg | 4,286 | 23.4% |
| 17 | Canton | 4,153 | 4.1% |
| 18 | Hot Springs | 4,077 | -0.2% |
| 19 | Tea | 3,947 | 11.9% |
| 20 | Box Elder | 3,804 | 1.5% |
| 21 | Milbank | 3,230 | -1.7% |
| 22 | Mobridge | 3,163 | -1.6% |
| 23 | Dell Rapids | 3,076 | 0.4% |
| 24 | Lead | 2,876 | -0.7% |
| 25 | Lennox | 2,766 | 4.3% |
| 26 | Winner | 2,764 | -1.7% |
| 27 | North Sioux City | 2,534 | 1.5% |
| 28 | Sisseton | 2,472 | -0.4% |
| 29 | Flandreau | 2,268 | -0.6% |
| 30 | Redfield | 2,265 | -1.5% |
| 31 | Chamberlain | 2,258 | -0.5% |
| 32 | Beresford | 2,204 | 1.4% |
| 33 | Fort Pierre | 2,100 | 0.4% |
| 34 | Hartford | 2,066 | 1.3% |
| 35 | Custer | 1,989 | 0.1% |
| 36 | Elk Point | 1,892 | 1.4% |
| 37 | Webster | 1,711 | -1.8% |
| 38 | Volga | 1,577 | 1.1% |
| 39 | Wagner | 1,503 | -1.0% |
| 40 | Parkston | 1,494 | -1.6% |
| 41 | Springfield | 1,490 | -0.7% |
| 42 | Groton | 1,397 | 0.5% |
| 43 | Salem | 1,338 | -0.6% |
| 44 | Miller | 1,337 | -1.9% |
| 45 | Deadwood | 1,288 | -0.9% |
| 46 | Platte | 1,285 | -0.8% |
| 47 | Britton | 1,236 | -1.0% |
| 48 | Mission | 1,206 | 4.2% |
| 49 | Clear Lake | 1,205 | -1.4% |
| 50 | Lemmon | 1,192 | -2.2% |
| 51 | Freeman | 1,186 | -1.5% |
| 52 | Gregory | 1,181 | -2.3% |
| 53 | Tyndall | 1,107 | -1.6% |
| 54 | Worthing | 1,099 | 9.0% |
| 55 | Garretson | 1,096 | -0.9% |
| 56 | Gettysburg | 1,089 | -2.9% |
| 57 | Crooks | 1,081 | 3.2% |
| 58 | Clark | 1,080 | -2.4% |
| 59 | De Smet | 1,080 | -1.5% |
| 60 | Martin | 999 | -1.1% |
| 61 | Parker | 978 | -0.9% |
| 62 | Eureka | 945 | -2.2% |
| 63 | Eagle Butte | 942 | 0.5% |
| 64 | Arlington | 918 | -1.1% |
| 65 | Hill City | 896 | 1.9% |
| 66 | Howard | 894 | -2.5% |
| 67 | Alcester | 893 | 0.2% |
| 68 | Baltic | 883 | 1.0% |
| 69 | Whitewood | 849 | 0.1% |
| 70 | Ipswich | 849 | -1.5% |
| 71 | Centerville | 848 | -1.0% |
| 72 | Wessington Springs | 837 | -2.6% |
| 73 | Marion | 821 | -1.2% |
| 74 | Wall | 805 | -0.2% |
| 75 | Scotland | 794 | -1.6% |
| 76 | Edgemont | 789 | -1.2% |
| 77 | Viborg | 776 | -1.0% |
| 78 | Valley Springs | 775 | -0.4% |
| 79 | St. Francis | 762 | 1.1% |
| 80 | Lake Andes | 760 | -1.0% |
| 81 | McLaughlin | 738 | -0.5% |
| 82 | Philip | 728 | -2.6% |
| 83 | Highmore | 720 | -2.3% |
| 84 | Kimball | 685 | -1.1% |
| 85 | New Underwood | 678 | 1.2% |
| 86 | Armour | 677 | -1.9% |
| 87 | Faulkton | 673 | -2.1% |
| 88 | Castlewood | 670 | 0.1% |
| 89 | Canistota | 668 | -0.7% |
| 90 | Estelline | 662 | -0.3% |
| 91 | Menno | 662 | -1.3% |
| 92 | Selby | 655 | -1.6% |
| 93 | Lake Preston | 648 | -1.8% |
| 94 | Alexandria | 646 | 1.9% |
| 95 | Onida | 646 | -1.8% |
| 96 | Woonsocket | 644 | -1.6% |
| 97 | Kadoka | 642 | -1.4% |
| 98 | Tripp | 637 | -1.6% |
| 99 | Presho | 635 | 1.0% |
| 100 | Elkton | 634 | -0.9% |
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