| Rank | City | 2004 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 137,575 | 3.1% |
| 2 | Rapid City | 61,031 | 0.5% |
| 3 | Aberdeen | 24,762 | -0.6% |
| 4 | Watertown | 20,146 | -0.2% |
| 5 | Brookings | 19,009 | 0.3% |
| 6 | Mitchell | 14,641 | 0.1% |
| 7 | Pierre | 13,852 | -0.1% |
| 8 | Yankton | 13,551 | 0.1% |
| 9 | Huron | 11,288 | -1.6% |
| 10 | Vermillion | 10,219 | -0.1% |
| 11 | Spearfish | 8,923 | 0.9% |
| 12 | Brandon | 6,457 | 3.6% |
| 13 | Sturgis | 6,360 | -0.6% |
| 14 | Madison | 6,272 | -1.3% |
| 15 | Belle Fourche | 4,757 | -0.4% |
| 16 | Hot Springs | 4,063 | -0.7% |
| 17 | Milbank | 3,485 | -1.4% |
| 18 | Box Elder | 3,431 | 0.0% |
| 19 | Mobridge | 3,289 | -2.5% |
| 20 | Canton | 3,268 | 1.3% |
| 21 | Dell Rapids | 3,082 | 1.0% |
| 22 | Winner | 2,984 | -1.5% |
| 23 | Lead | 2,977 | -0.5% |
| 24 | Sisseton | 2,519 | -0.3% |
| 25 | North Sioux City | 2,378 | 1.3% |
| 26 | Redfield | 2,352 | -2.3% |
| 27 | Flandreau | 2,299 | -1.0% |
| 28 | Chamberlain | 2,259 | -1.3% |
| 29 | Tea | 2,209 | 7.2% |
| 30 | Lennox | 2,129 | 1.2% |
| 31 | Fort Pierre | 2,021 | -0.3% |
| 32 | Custer | 1,992 | 0.4% |
| 33 | Beresford | 1,988 | -0.3% |
| 34 | Hartford | 1,975 | 1.5% |
| 35 | Webster | 1,812 | -2.3% |
| 36 | Elk Point | 1,789 | 1.4% |
| 37 | Parkston | 1,586 | -1.7% |
| 38 | Springfield | 1,534 | -0.6% |
| 39 | Wagner | 1,534 | -1.6% |
| 40 | Volga | 1,450 | -0.2% |
| 41 | Miller | 1,429 | -2.3% |
| 42 | Salem | 1,378 | -0.3% |
| 43 | Groton | 1,347 | -0.1% |
| 44 | Deadwood | 1,328 | -1.1% |
| 45 | Platte | 1,307 | -1.4% |
| 46 | Lemmon | 1,281 | -2.7% |
| 47 | Gregory | 1,273 | -3.0% |
| 48 | Clear Lake | 1,272 | -1.5% |
| 49 | Freeman | 1,246 | -1.8% |
| 50 | Britton | 1,235 | -2.3% |
| 51 | Gettysburg | 1,233 | -2.6% |
| 52 | Clark | 1,192 | -2.3% |
| 53 | Tyndall | 1,172 | -1.8% |
| 54 | Harrisburg | 1,152 | 5.3% |
| 55 | Garretson | 1,136 | -0.9% |
| 56 | De Smet | 1,125 | -2.2% |
| 57 | Eureka | 1,033 | -2.1% |
| 58 | Martin | 1,033 | -1.4% |
| 59 | Parker | 1,011 | -1.1% |
| 60 | Howard | 966 | -3.4% |
| 61 | Arlington | 953 | -1.4% |
| 62 | Eagle Butte | 952 | 1.5% |
| 63 | Crooks | 939 | 2.7% |
| 64 | Wessington Springs | 938 | -2.2% |
| 65 | Mission | 924 | 0.7% |
| 66 | Ipswich | 898 | -1.5% |
| 67 | Baltic | 886 | 2.5% |
| 68 | Alcester | 885 | 0.2% |
| 69 | Centerville | 872 | -1.3% |
| 70 | Marion | 848 | -1.6% |
| 71 | Whitewood | 846 | 0.1% |
| 72 | Scotland | 840 | -1.8% |
| 73 | Edgemont | 821 | -1.5% |
| 74 | Hill City | 818 | 1.5% |
| 75 | Wall | 818 | – |
| 76 | Valley Springs | 814 | 0.8% |
| 77 | Viborg | 809 | -1.0% |
| 78 | Philip | 808 | -2.7% |
| 79 | Highmore | 791 | -2.3% |
| 80 | Lake Andes | 778 | -1.6% |
| 81 | McLaughlin | 764 | -0.1% |
| 82 | St. Francis | 733 | 1.3% |
| 83 | Armour | 732 | -2.0% |
| 84 | Faulkton | 731 | -2.2% |
| 85 | Worthing | 715 | 6.0% |
| 86 | Kimball | 698 | -2.0% |
| 87 | Menno | 698 | -1.2% |
| 88 | Woonsocket | 697 | -1.0% |
| 89 | Canistota | 696 | -0.3% |
| 90 | Selby | 691 | -1.9% |
| 91 | Tripp | 684 | -1.3% |
| 92 | Lake Preston | 683 | -2.5% |
| 93 | Estelline | 675 | -0.1% |
| 94 | Onida | 673 | -2.9% |
| 95 | Castlewood | 670 | 0.1% |
| 96 | Kadoka | 663 | -2.1% |
| 97 | Colton | 657 | -0.3% |
| 98 | Elkton | 640 | -1.9% |
| 99 | Newell | 631 | -0.9% |
| 100 | New Underwood | 629 | 0.3% |
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