| Rank | City | 2003 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 133,281 | 3.0% |
| 2 | Rapid City | 60,683 | 0.5% |
| 3 | Aberdeen | 24,791 | -0.8% |
| 4 | Watertown | 20,199 | -0.2% |
| 5 | Brookings | 19,064 | 0.6% |
| 6 | Mitchell | 14,642 | 0.1% |
| 7 | Pierre | 13,869 | -0.1% |
| 8 | Yankton | 13,479 | -0.1% |
| 9 | Huron | 11,533 | -1.4% |
| 10 | Vermillion | 10,222 | -0.1% |
| 11 | Spearfish | 8,693 | 0.1% |
| 12 | Sturgis | 6,428 | -0.4% |
| 13 | Madison | 6,384 | -1.1% |
| 14 | Brandon | 6,183 | 3.2% |
| 15 | Belle Fourche | 4,719 | -1.0% |
| 16 | Hot Springs | 4,063 | -1.0% |
| 17 | Milbank | 3,509 | -1.7% |
| 18 | Box Elder | 3,464 | 0.5% |
| 19 | Mobridge | 3,389 | -2.3% |
| 20 | Canton | 3,256 | 1.8% |
| 21 | Winner | 3,035 | -1.4% |
| 22 | Dell Rapids | 3,030 | 0.6% |
| 23 | Lead | 2,987 | -0.6% |
| 24 | Sisseton | 2,495 | -1.0% |
| 25 | Redfield | 2,403 | -2.4% |
| 26 | Flandreau | 2,330 | -0.9% |
| 27 | North Sioux City | 2,318 | 0.7% |
| 28 | Chamberlain | 2,256 | -1.9% |
| 29 | Lennox | 2,117 | 1.5% |
| 30 | Tea | 2,109 | 8.5% |
| 31 | Custer | 2,006 | 0.9% |
| 32 | Beresford | 1,999 | -0.1% |
| 33 | Fort Pierre | 1,996 | -1.1% |
| 34 | Hartford | 1,933 | 1.2% |
| 35 | Webster | 1,862 | -2.1% |
| 36 | Elk Point | 1,778 | 1.8% |
| 37 | Parkston | 1,597 | -2.2% |
| 38 | Wagner | 1,560 | -1.5% |
| 39 | Springfield | 1,538 | -0.8% |
| 40 | Volga | 1,498 | 1.4% |
| 41 | Miller | 1,460 | -2.4% |
| 42 | Salem | 1,386 | -0.2% |
| 43 | Groton | 1,342 | -0.4% |
| 44 | Lemmon | 1,334 | -2.0% |
| 45 | Deadwood | 1,332 | -1.5% |
| 46 | Platte | 1,326 | -1.4% |
| 47 | Clear Lake | 1,311 | -0.8% |
| 48 | Gregory | 1,300 | -3.4% |
| 49 | Britton | 1,261 | -2.4% |
| 50 | Freeman | 1,256 | -2.2% |
| 51 | Gettysburg | 1,248 | -3.3% |
| 52 | Clark | 1,217 | -2.4% |
| 53 | Tyndall | 1,184 | -2.1% |
| 54 | De Smet | 1,150 | -2.3% |
| 55 | Garretson | 1,148 | -0.9% |
| 56 | Harrisburg | 1,077 | 4.5% |
| 57 | Eureka | 1,050 | -2.3% |
| 58 | Martin | 1,044 | -1.5% |
| 59 | Howard | 1,015 | -2.6% |
| 60 | Parker | 1,009 | -1.7% |
| 61 | Arlington | 968 | -1.3% |
| 62 | Wessington Springs | 963 | -2.0% |
| 63 | Eagle Butte | 950 | 2.1% |
| 64 | Mission | 924 | 1.0% |
| 65 | Ipswich | 914 | -1.4% |
| 66 | Crooks | 907 | 2.3% |
| 67 | Alcester | 881 | 0.1% |
| 68 | Centerville | 873 | -1.9% |
| 69 | Baltic | 871 | 2.9% |
| 70 | Marion | 854 | -2.1% |
| 71 | Scotland | 847 | -2.3% |
| 72 | Whitewood | 841 | -0.2% |
| 73 | Philip | 829 | -2.8% |
| 74 | Edgemont | 828 | -1.8% |
| 75 | Wall | 825 | 0.4% |
| 76 | Hill City | 815 | 2.0% |
| 77 | Viborg | 813 | -1.3% |
| 78 | Valley Springs | 799 | 0.3% |
| 79 | Lake Andes | 792 | -1.5% |
| 80 | Highmore | 783 | -3.9% |
| 81 | McLaughlin | 763 | -0.3% |
| 82 | Armour | 749 | -1.8% |
| 83 | Faulkton | 746 | -2.3% |
| 84 | St. Francis | 726 | 1.5% |
| 85 | Selby | 707 | -1.8% |
| 86 | Canistota | 704 | 0.1% |
| 87 | Kimball | 702 | -2.7% |
| 88 | Onida | 701 | -2.3% |
| 89 | Menno | 699 | -1.7% |
| 90 | Lake Preston | 698 | -2.7% |
| 91 | Tripp | 691 | -1.5% |
| 92 | Woonsocket | 688 | -2.2% |
| 93 | Worthing | 685 | 6.8% |
| 94 | Estelline | 680 | 0.1% |
| 95 | Kadoka | 665 | -3.0% |
| 96 | Castlewood | 665 | -0.2% |
| 97 | Elkton | 661 | -1.2% |
| 98 | Colton | 654 | -0.7% |
| 99 | Waubay | 639 | -1.5% |
| 100 | Burke | 634 | -2.9% |
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