| Rank | City | 2002 Population (Est.) | Growth Rate (Annual) |
|---|---|---|---|
| 1 | Sioux Falls | 129,980 | 3.5% |
| 2 | Rapid City | 60,436 | 0.6% |
| 3 | Aberdeen | 24,961 | -0.9% |
| 4 | Watertown | 20,234 | -0.2% |
| 5 | Brookings | 18,867 | 0.2% |
| 6 | Mitchell | 14,658 | 0.3% |
| 7 | Pierre | 13,779 | -0.7% |
| 8 | Yankton | 13,439 | -0.5% |
| 9 | Huron | 11,725 | -1.2% |
| 10 | Vermillion | 10,294 | 0.4% |
| 11 | Spearfish | 8,640 | -0.4% |
| 12 | Madison | 6,536 | 0.2% |
| 13 | Sturgis | 6,444 | -0.5% |
| 14 | Brandon | 5,980 | 2.9% |
| 15 | Belle Fourche | 4,789 | -0.5% |
| 16 | Hot Springs | 4,109 | -0.9% |
| 17 | Milbank | 3,553 | -2.2% |
| 18 | Mobridge | 3,466 | -2.3% |
| 19 | Box Elder | 3,459 | 0.9% |
| 20 | Canton | 3,191 | 1.6% |
| 21 | Winner | 3,064 | -1.8% |
| 22 | Lead | 3,016 | -0.2% |
| 23 | Dell Rapids | 2,988 | -0.2% |
| 24 | Sisseton | 2,543 | -0.0% |
| 25 | Redfield | 2,448 | -3.0% |
| 26 | Flandreau | 2,366 | -0.3% |
| 27 | North Sioux City | 2,296 | 0.3% |
| 28 | Chamberlain | 2,293 | -2.3% |
| 29 | Lennox | 2,072 | 0.9% |
| 30 | Fort Pierre | 2,012 | -1.5% |
| 31 | Beresford | 1,990 | -0.6% |
| 32 | Custer | 1,987 | 0.8% |
| 33 | Hartford | 1,896 | 0.5% |
| 34 | Webster | 1,891 | -2.7% |
| 35 | Tea | 1,890 | 5.5% |
| 36 | Elk Point | 1,731 | 0.8% |
| 37 | Parkston | 1,630 | -2.3% |
| 38 | Wagner | 1,578 | -1.9% |
| 39 | Springfield | 1,553 | -0.6% |
| 40 | Miller | 1,496 | -2.4% |
| 41 | Volga | 1,462 | 0.3% |
| 42 | Salem | 1,404 | 0.9% |
| 43 | Lemmon | 1,355 | -2.5% |
| 44 | Deadwood | 1,349 | -1.8% |
| 45 | Groton | 1,344 | -0.7% |
| 46 | Gregory | 1,338 | -3.9% |
| 47 | Platte | 1,338 | -1.8% |
| 48 | Clear Lake | 1,329 | -0.2% |
| 49 | Britton | 1,295 | -2.3% |
| 50 | Freeman | 1,282 | -2.4% |
| 51 | Gettysburg | 1,275 | -4.4% |
| 52 | Clark | 1,274 | -0.2% |
| 53 | Tyndall | 1,217 | -1.5% |
| 54 | De Smet | 1,168 | -3.0% |
| 55 | Garretson | 1,154 | -1.2% |
| 56 | Eureka | 1,076 | -2.3% |
| 57 | Martin | 1,053 | -2.2% |
| 58 | Howard | 1,043 | -2.5% |
| 59 | Parker | 1,029 | -1.4% |
| 60 | Harrisburg | 1,023 | 3.8% |
| 61 | Wessington Springs | 982 | -2.1% |
| 62 | Arlington | 973 | -2.0% |
| 63 | Eagle Butte | 951 | 4.4% |
| 64 | Ipswich | 933 | -0.9% |
| 65 | Mission | 917 | 1.2% |
| 66 | Centerville | 892 | -1.8% |
| 67 | Alcester | 877 | -0.2% |
| 68 | Marion | 877 | -1.6% |
| 69 | Crooks | 877 | 1.2% |
| 70 | Scotland | 871 | -1.9% |
| 71 | Philip | 855 | -2.5% |
| 72 | Baltic | 849 | 3.2% |
| 73 | Edgemont | 848 | -1.3% |
| 74 | Whitewood | 842 | -0.2% |
| 75 | Viborg | 835 | 0.1% |
| 76 | Wall | 822 | 0.5% |
| 77 | Highmore | 816 | -3.7% |
| 78 | Lake Andes | 802 | -1.8% |
| 79 | Hill City | 796 | 1.7% |
| 80 | Valley Springs | 786 | -1.1% |
| 81 | Armour | 769 | -1.0% |
| 82 | McLaughlin | 759 | -1.0% |
| 83 | Faulkton | 758 | -2.9% |
| 84 | Onida | 727 | -1.1% |
| 85 | Selby | 719 | -1.9% |
| 86 | Kimball | 719 | -3.1% |
| 87 | St. Francis | 716 | 1.6% |
| 88 | Lake Preston | 715 | -3.0% |
| 89 | Menno | 710 | -1.8% |
| 90 | Canistota | 707 | 0.6% |
| 91 | Tripp | 706 | -0.8% |
| 92 | Woonsocket | 691 | -3.9% |
| 93 | Estelline | 683 | 0.7% |
| 94 | Kadoka | 672 | -5.0% |
| 95 | Elkton | 671 | -0.9% |
| 96 | Castlewood | 665 | -0.3% |
| 97 | Colton | 654 | -1.4% |
| 98 | Burke | 649 | -3.4% |
| 99 | Newell | 642 | -0.9% |
| 100 | Waubay | 641 | -2.7% |
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