| Rank |
County |
Population (2012) |
| 1 |
Greenville County, South Carolina
|
467,605
|
| 2 |
Richland County, South Carolina
|
393,830
|
| 3 |
Charleston County, South Carolina
|
365,162
|
| 4 |
Spartanburg County, South Carolina
|
288,745
|
| 5 |
Horry County, South Carolina
|
282,285
|
| 6 |
Lexington County, South Carolina
|
270,406
|
| 7 |
York County, South Carolina
|
234,635
|
| 8 |
Berkeley County, South Carolina
|
189,781
|
| 9 |
Anderson County, South Carolina
|
189,355
|
| 10 |
Beaufort County, South Carolina
|
168,049
|
| 11 |
Aiken County, South Carolina
|
162,812
|
| 12 |
Dorchester County, South Carolina
|
142,496
|
| 13 |
Florence County, South Carolina
|
137,948
|
| 14 |
Pickens County, South Carolina
|
119,670
|
| 15 |
Sumter County, South Carolina
|
108,052
|
| 16 |
Orangeburg County, South Carolina
|
91,476
|
| 17 |
Lancaster County, South Carolina
|
79,089
|
| 18 |
Oconee County, South Carolina
|
74,627
|
| 19 |
Greenwood County, South Carolina
|
69,756
|
| 20 |
Darlington County, South Carolina
|
68,139
|
| 21 |
Laurens County, South Carolina
|
66,223
|
| 22 |
Kershaw County, South Carolina
|
62,343
|
| 23 |
Georgetown County, South Carolina
|
60,189
|
| 24 |
Cherokee County, South Carolina
|
55,662
|
| 25 |
Chesterfield County, South Carolina
|
46,103
|
| 26 |
Colleton County, South Carolina
|
38,153
|
| 27 |
Newberry County, South Carolina
|
37,576
|
| 28 |
Clarendon County, South Carolina
|
34,357
|
| 29 |
Williamsburg County, South Carolina
|
33,620
|
| 30 |
Chester County, South Carolina
|
32,546
|
| 31 |
Marion County, South Carolina
|
32,457
|
| 32 |
Dillon County, South Carolina
|
31,446
|
| 33 |
Union County, South Carolina
|
28,252
|
| 34 |
Marlboro County, South Carolina
|
28,145
|
| 35 |
Edgefield County, South Carolina
|
26,347
|
| 36 |
Jasper County, South Carolina
|
25,833
|
| 37 |
Abbeville County, South Carolina
|
25,101
|
| 38 |
Fairfield County, South Carolina
|
23,363
|
| 39 |
Barnwell County, South Carolina
|
22,212
|
| 40 |
Hampton County, South Carolina
|
20,726
|
| 41 |
Saluda County, South Carolina
|
19,893
|
| 42 |
Lee County, South Carolina
|
18,654
|
| 43 |
Bamberg County, South Carolina
|
15,763
|
| 44 |
Calhoun County, South Carolina
|
14,910
|
| 45 |
Allendale County, South Carolina
|
9,988
|
| 46 |
McCormick County, South Carolina
|
9,943
|