| Rank | Congressional District | Population (2012) | 
|---|---|---|
| 1 | South Carolina 1st Congressional District | 699,487 | 
| 2 | South Carolina 5th Congressional District | 675,124 | 
| 3 | South Carolina 4th Congressional District | 673,673 | 
| 4 | South Carolina 7th Congressional District | 671,575 | 
| 5 | South Carolina 2nd Congressional District | 670,436 | 
| 6 | South Carolina 6th Congressional District | 667,790 | 
| 7 | South Carolina 3rd Congressional District | 665,638 | 
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