| Rank |
City |
Population (2012) |
| 1 |
Columbia, South Carolina
|
131,686
|
| 2 |
Charleston, South Carolina
|
125,583
|
| 3 |
North Charleston, South Carolina
|
101,989
|
| 4 |
Mount Pleasant, South Carolina
|
71,875
|
| 5 |
Rock Hill, South Carolina
|
68,094
|
| 6 |
Greenville, South Carolina
|
60,709
|
| 7 |
Summerville, South Carolina
|
44,719
|
| 8 |
Sumter, South Carolina
|
40,836
|
| 9 |
Goose Creek, South Carolina
|
38,579
|
| 10 |
Hilton Head Island, South Carolina
|
38,366
|
| 11 |
Florence, South Carolina
|
37,498
|
| 12 |
Spartanburg, South Carolina
|
37,401
|
| 13 |
Aiken, South Carolina
|
29,884
|
| 14 |
Myrtle Beach, South Carolina
|
28,292
|
| 15 |
Anderson, South Carolina
|
26,708
|
| 16 |
Greer, South Carolina
|
26,645
|
| 17 |
Mauldin, South Carolina
|
23,808
|
| 18 |
Greenwood, South Carolina
|
23,324
|
| 19 |
North Augusta, South Carolina
|
21,873
|
| 20 |
Easley, South Carolina
|
20,098
|
| 21 |
Hanahan, South Carolina
|
19,157
|
| 22 |
Lexington, South Carolina
|
19,141
|
| 23 |
Simpsonville, South Carolina
|
19,056
|
| 24 |
Conway, South Carolina
|
18,688
|
| 25 |
West Columbia, South Carolina
|
15,631
|
| 26 |
North Myrtle Beach, South Carolina
|
14,472
|
| 27 |
Clemson, South Carolina
|
14,089
|
| 28 |
Orangeburg, South Carolina
|
13,850
|
| 29 |
Bluffton, South Carolina
|
12,932
|
| 30 |
Beaufort, South Carolina
|
12,788
|
| 31 |
Cayce, South Carolina
|
12,679
|
| 32 |
Gaffney, South Carolina
|
12,449
|
| 33 |
Irmo, South Carolina
|
11,500
|
| 34 |
Fort Mill, South Carolina
|
11,387
|
| 35 |
Port Royal, South Carolina
|
11,265
|
| 36 |
Forest Acres, South Carolina
|
10,489
|
| 37 |
Newberry, South Carolina
|
10,255
|
| 38 |
Georgetown, South Carolina
|
9,092
|
| 39 |
Laurens, South Carolina
|
9,083
|
| 40 |
Bennettsville, South Carolina
|
8,873
|
| 41 |
Lancaster, South Carolina
|
8,755
|
| 42 |
Moncks Corner, South Carolina
|
8,662
|
| 43 |
Clinton, South Carolina
|
8,484
|
| 44 |
Union, South Carolina
|
8,183
|
| 45 |
Seneca, South Carolina
|
8,098
|
| 46 |
Tega Cay, South Carolina
|
7,934
|
| 47 |
Fountain Inn, South Carolina
|
7,898
|
| 48 |
York, South Carolina
|
7,883
|
| 49 |
Hartsville, South Carolina
|
7,850
|
| 50 |
Camden, South Carolina
|
6,906
|
| 51 |
Marion, South Carolina
|
6,839
|
| 52 |
Lake City, South Carolina
|
6,715
|
| 53 |
Dillon, South Carolina
|
6,669
|
| 54 |
Darlington, South Carolina
|
6,221
|
| 55 |
Cheraw, South Carolina
|
5,785
|
| 56 |
Chester, South Carolina
|
5,517
|
| 57 |
Batesburg-Leesville, South Carolina
|
5,397
|
| 58 |
Walterboro, South Carolina
|
5,309
|
| 59 |
Clover, South Carolina
|
5,287
|
| 60 |
Abbeville, South Carolina
|
5,179
|
| 61 |
Central, South Carolina
|
5,154
|